Ask about this productRelated genes to: SOX4 antibody
- Gene:
- CASC15 NIH gene
- Name:
- cancer susceptibility 15
- Previous symbol:
- LINC00340
- Synonyms:
- lnc-SOX4-1
- Chromosome:
- 6p22.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2011-08-10
- Date modifiied:
- 2018-07-25
- Gene:
- SOX4 NIH gene
- Name:
- SRY-box 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-30
- Date modifiied:
- 2015-11-23
Related products to: SOX4 antibody
Related articles to: SOX4 antibody
- Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are involved in the hypoxia-related cancer process and play pivotal roles in enabling malignant cells to survive under hypoxic stress. However, the molecular crosstalk between lncRNAs and hypoxia signaling cascades in non-small cell lung cancer (NSCLC) remains largely elusive. - Source: PubMed
Publication date: 2021/01/06
Sun JianyongXiong YanluJiang KuoXin BoJiang TongtongWei RenjiZou YuankangTan HongJiang TaoYang AngangJia LintaoWang Lei - The present study aimed to investigate the function of lncRNA (cancer susceptibility candidate 15) in hepatocellular carcinoma (HCC), as well as its regulatory roles in expression and Wnt/β-catenin pathway. Quantitative real-time polymerase chain reaction (QRT-PCR) method was used to detect the relative expression of mRNA in HCC tissues. Protein detection was performed by western blot. Luciferase assay was used to confirm the potential target of in HCC. Cell proliferation, migration and invasion, as well as apoptosis were analyzed using MTT, transwell assays and flow cytometry in vitro, respectively. The expression of was significantly increased in HCC tissues ( < .001) and showed positive correlation with tumour size ( = .016), TNM stage ( = .018) and metastasis ( = .021). The knockdown of could obviously inhibit HCC cell proliferation, migration and invasion and promote cell apoptosis in vitro ( < .05 for all). Furthermore, the protein levels of , β-catenin, Cyclin D1 and c-Myc also exhibited decreased trends after inhibition. Luciferase assay confirmed that might be a targeted gene of in HCC. In HCC, may activate the Wnt/β-catenin pathway via enhancing the expression of , thus promote tumour progression. - Source: PubMed
Wang ChaoyangZi HaoWang YangLi BinghuiGe ZhengRen Xuequn - Long noncoding RNA cancer susceptibility candidate 15 (CASC15) facilitates progression of hepatocellular carcinoma (HCC) cells, but the molecular mechanisms remain unknown. CASC15 co-expressing genes were explored in the Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset. Putative co-expressing genes were analyzed by Gene Ontology and biological pathway enrichment analysis. CASC15 overexpression or knockdown and TWIST1 overexpression or knockdown in HCC cells was achieved by lentiviral transduction or plasmid transfection. Interaction between CASC15 and microRNA-33a-5p (miR-33a-5p) was verified by argonaute 2-RNA Immunoprecipitation (AGO2-RIP) and luciferase reporter assays. HCC cell malignancy was determined by cell proliferation, apoptosis, migration and invasion assays. Tumorigenicity was evaluated by xenograft assay. Epithelial-to-mesenchymal transition (EMT) of HCC cells was assessed by Western blot. TWIST1, sex-determining region Y-related high-mobility group box 4 (Sox4) and Versican were found as putative CASC15 co-expressing genes. CASC15 positively regulated TWIST1 gene expression as well as protein level of Sox4 and Versican in HCC cells. Positive correlation in expression between CASC15 and TWIST1 mRNA was verified in 42 pairs of HCC pathologic and adjacent tissue specimens. CASC15 upregulated TWIST1 gene expression in HCC cells by sponging miR-33a-5p. CASC15 promoted EMT in HCC cells by increasing N-cadherin and Vimentin protein level while decreasing that of E-cadherin through TWIST1. CASC15 facilitated HCC cell proliferation, migration and invasion while reducing cell apoptosis through TWIST1. CASC15 facilitated the tumorigenicity of HCC cells in vivo. a CASC15 could promote EMT and facilitate malignancy of HCC cells by increasing TWIST1 gene expression via miR-33a-5p sponging. - Source: PubMed
Publication date: 2019/08/08
Li YangChen GongbinYan YanjuFan Qingxia - Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia. - Source: PubMed
Publication date: 2017/07/19
Fernando Thilini RContreras Jorge RZampini MatteoRodriguez-Malave Norma IAlberti Michael OAnguiano JaimeTran Tiffany MPalanichamy Jayanth KGajeton JasmineUng Nolan MAros Cody JWaters Ella VCasero DavidBasso GiuseppePigazzi MartinaRao Dinesh S