Ask about this productRelated genes to: MARS antibody
- Gene:
- MARS NIH gene
- Name:
- methionyl-tRNA synthetase
- Previous symbol:
- -
- Synonyms:
- MetRS, SPG70, CMT2U
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-06-25
Related products to: MARS antibody
Related articles to: MARS antibody
- Hemodialysis is a life-sustaining treatment for patients with end-stage renal disease, but it is notoriously resource-intensive, requiring vast quantities of high-purity water. This significant water footprint presents economic and environmental challenges, particularly in water-scarce regions. Forward osmosis (FO), an emerging membrane technology, offers a promising alternative to conventional reverse osmosis (RO) for dialysate preparation and regeneration by leveraging osmotic energy rather than hydraulic pressure. This literature review synthesizes current research on the application of FO in hemodialysis, focusing on its potential to reduce water usage, its operational principles, and the technical challenges hindering its widespread adoption. The analysis covers FO's roles in direct dialysate preparation from tap water and spent dialysate regeneration, its energy efficiency advantages, and critical hurdles such as membrane performance and draw solution recovery. The review concludes that while FO holds considerable promise for creating more sustainable and portable dialysis systems, targeted research into membrane optimization, biocompatible draw solutions, and hybrid systems is essential for its clinical translation. - Source: PubMed
Tarrass FaissalBenjelloun Meryem - Ancylostoma caninum, the canine hookworm, is the most common and clinically important gastrointestinal nematode parasite infecting dogs in the US. Common clinical signs associated with acute infections include anemia, melena, hematochezia, dehydration, and poor weight gain or weight loss. In the past few years, multiple anthelmintic drug resistance to fenbendazole, moxidectin, and pyrantel pamoate has been documented in A caninum in the US, and cases of drug-resistant canine hookworms are increasingly being reported in the US and Canada. Clinical and genetic evidence strongly suggests that multiple anthelmintic drug-resistant A caninum likely originated on Greyhound breeding farms and kennels. However, the problem is no longer restricted to Greyhounds; several large national studies have shown that drug-resistant A caninum was present in dogs of all sizes, ages, and breeds and at varying but always high prevalence in every region of the continental US. The high prevalence and wide distribution of drug-resistant hookworms present a matter of urgent concern for veterinarians in North America and elsewhere. In response to this concern, the American Association of Veterinary Parasitologists established a Hookworm Task Force in 2021, and this paper is a result of the work of that task force. Here we provide guidance on best practices for diagnosis, treatment, and management of drug-resistant hookworm cases and summarize relevant studies to help veterinarians understand what is known about the biology, prevalence, and epidemiology of these parasites. - Source: PubMed
Publication date: 2026/05/08
Kaplan Ray MJimenez Castro Pablo DMarsh Antoinette EJesudoss Chelladurai Jeba R JGilleard John S - Mutations that arise in the shoot apical meristems can become fixed, but typically only in one of the meristem layers. Therefore, in long-lived, clonally propagated species, polymorphic genomes coexist in the form of periclinal chimeras. Given their evolutionary and economic impact, it is critical to understand the dynamics and phenotypic implications of layer-specific variation. Here, we γ-irradiated axillary buds from an elite peppermint clone and obtained 261 independent mutants carrying large indels. We produced a haplotype-aware, high-continuity assembly of this sterile allohexaploid and, using short-read sequencing, detected, on average, six large indels per mutant. Importantly, most of these mutants were periclinal chimeras: comparison of mutation frequency in root (derived solely from the L2/3 layer) and leaves (which contain cells from all three layers) demonstrated that the indels are confined to either the outer, L1-derived layer, or the inner L2/3 layers. We observed that the L1 layer was more often mutated, confirming that mutation rate in the shoot apical meristem is potentially optimized to each meristematic layer. To assess whether deletion of a single haplotype in a single meristematic layer could affect plant function, we characterized mutants under field conditions, detecting variation in secondary metabolite production. Two mutants produced an oil with very low (-)-menthol levels, associated with the loss of a single haplotype of the menthone-menthol reductase gene in the epidermal layer. These results highlight the evolutionary relevance of layer-specific genetic variation and present opportunities for improvement of clonally propagated crops that suffer from genetic diversity bottlenecks. - Source: PubMed
Publication date: 2026/05/08
Kippes NestorLieberman Meric CCulp DarrinDeMarco Isabelle JTsai Helen TMasuda KanaeTerzaroli NiccolòLopez JordanWilson Robert GComai LucaHenry Isabelle M - Climate change may exacerbate biological invasion by expanding the distribution of invasive species. (Temminck & Schlegel, 1846) is a prevalent invasive fish species. It has posed significant threats to biodiversity and ecosystems in over 40 countries across Asia, Europe, and Africa. To avoid or mitigate its threats, it is necessary to evaluate its invasion risk. Species distribution models (SDMs), using occurrence data and bioclimatic factors, serve as critical tools for evaluating biological invasion risks. ANN, FDA, GAM, GBM, MARS, and RF are prominent individual algorithms. Ensemble models are generally considered better than individual algorithms as they can effectively reduce uncertainties. However, no study has yet used ensemble models to forecast the global distribution of under future climate change. Therefore, the aim of this study was to use ensemble SDMs, combined by above-mentioned six individual algorithms, to predict the global potential suitable habitats and influencing factors of under current and future climate change. Global occurrence data for were collected from online biodiversity platforms and literature databases. Bioclimatic variables were from WorldClim and ENVIREM. The results showed as follows: (1) The ensemble model demonstrated excellent performance with an AUC of 0.993; (2) The two bioclimatic factors exerting the most significant influence on distribution were the maximum temperature of the coldest month and isothermality, contributing 51.362% and 18.279% respectively; (3) The distribution of in the current period, as generated by the ensemble model, revealed that the primary invasion areas are concentrated at latitude 22°-55° N; (4) Future projections under various climate scenarios indicated an overall range expansion, with high-latitude or high-altitude regions becoming increasingly favorable. These findings suggest that the future global expansion trend of should not be ignored and effective management policies for its invasion should be provided. - Source: PubMed
Publication date: 2026/05/05
Li HaoSun WenqianXiong WenJu TaoWang WenhuiTang LiWang ZhengxiangGao XinPan LeiDong XianghongPeng Yu - Although sedation is commonly used in patients undergoing venovenous extracorporeal membrane oxygenation (V-V ECMO), the use of volatile anesthetics is less frequent, and there is limited data on the pharmacokinetics/pharmacodynamics (PK/PD) of these sedatives (e.g., sevoflurane) directly vaporized into ECMO circuits. We aimed to develop a kinetic model for sevoflurane vaporized in ex vivo ECMO oxygenators to inform the design of a pilot clinical trial to evaluate the safety, feasibility, and in vivo PK/PD model of such a strategy in patients supported with V-V ECMO. - Source: PubMed
Publication date: 2026/05/07
Morales Castro DianaAlm MarkCarini Federico CarlosFischer CourtneyRoman-Sarita GeorgianaDresser LindaGranton JohnChen EricShekar KiranFan Eddy