Ask about this productRelated genes to: DACH2 antibody
- Gene:
- DACH2 NIH gene
- Name:
- dachshund family transcription factor 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xq21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-08
- Date modifiied:
- 2016-10-05
Related products to: DACH2 antibody
Related articles to: DACH2 antibody
- - Source: PubMed
Publication date: 2026/03/16
Berkel Caglar - Assessing genetic diversity in various native poultry breeds, including bantam/dwarf ones, is instrumental for their conservation as genetic resources, identifying their specific genetic features, and exploring the history of their genetic divergence. Rare chicken breeds are usually carriers of peculiar phenotypic traits, including adaptations to local conditions, disease resistance, and unique performance features. Here, we report for the first time SNP-based genetic characterization of the Russian Korolyok, translated as "kinglet," relative to five other dwarf/small breeds: Cochin Bantam, Hamburg Bantam Silver Spangled, Polish White-crested Black, Red White-tailed Dwarf and Silkie White. We estimated phenotypes, heterozygosity, inbreeding, effective population size, and runs of homozygosity (ROHs). Some breeds had higher genetic diversity and others showed elevated inbreeding rates in their genomes. With lower effective population sizes (both presently and in the past), rare breeds came from a limited number of ancestors or were under strong selection pressure over many generations. Within 22 ROHs, we identified 26 prioritized candidate genes (, , , , , , , , , , , , , , , , , , , etc.). Our data offer whole-genome insights into genetic variability, history, phylogeny, selective sweeps, and candidate genes of a distinct indigenous Russian chicken breed and other bantam/dwarf breeds. - Source: PubMed
Publication date: 2026/02/17
Dementieva Natalia VShcherbakov Yuri SVakhrameev Anatoli BRomanov Michael N - Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10) but identified seven X-chromosome-wide significant loci (P ≤ 1.6 × 10). The index variants were common for the Xp22.32, FRMPD4, DMD and Xq25 loci, and rare for the WNK3, PJA1, and DACH2 loci. Overall, this well-powered XWAS found no genetic risk factors for AD on the non-pseudoautosomal region of the X-chromosome, but it identified suggestive signals warranting further investigations. - Source: PubMed
Publication date: 2024/12/04
Le Borgne JulieGomez LissetteHeikkinen SamiAmin NajafAhmad ShahzadChoi Seung HoanBis JoshuaGrenier-Boley BenjaminRodriguez Omar GarciaKleineidam LucaYoung JuanTripathi Kumar ParijatWang LilyVarma AchintyaCampos-Martin Rafaelvan der Lee SvenDamotte Vincentde Rojas ItziarPalmal Sagnik Lipton RichardReiman EricMcKee AnnDe Jager PhilipBush WilliamSmall ScottLevey AllanSaykin AndrewForoud TatianaAlbert MarilynHyman BradleyPetersen RonaldYounkin StevenSano MaryWisniewski ThomasVassar RobertSchneider JulieHenderson VictorRoberson ErikDeCarli CharlesLaFerla FrankBrewer JamesSwerdlow RussellVan Eldik LindaHamilton-Nelson KaraPaulson HenryNaj AdamLopez OscarChui HelenaCrane PaulGrabowski ThomasKukull WalterAsthana SanjayCraft SuzanneStrittmatter StephenCruchaga CarlosLeverenz JamesGoate AlisonKamboh M IlyasGeorge-Hyslop Peter StValladares OttoKuzma AmandaCantwell LauraRiemenschneider MatthiasMorris JohnSlifer SusanDalmasso CarolinaCastillo AtahualpaKüçükali FahriPeters OliverSchneider AnjaDichgans MartinRujescu DanScherbaum NorbertDeckert JürgenRiedel-Heller SteffiHausner LucreziaMolina-Porcel LauraDüzel EmrahGrimmer TimoWiltfang JensHeilmann-Heimbach StefanieMoebus SusanneTegos ThomasScarmeas NikolaosDols-Icardo OriolMoreno FerminPérez-Tur JordiBullido María JPastor PauSánchez-Valle RaquelÁlvarez VictoriaBoada MercèGarcía-González PabloPuerta RaquelMir PabloReal Luis MPiñol-Ripoll GerardGarcía-Alberca Jose MaríaRoyo Jose LuísRodriguez-Rodriguez EloySoininen Hilkkade Mendonça AlexandreMehrabian ShimaTraykov LatchezarHort JakubVyhnalek MartinThomassen Jesper QvistPijnenburg Yolande A LHolstege Hennevan Swieten JohnRamakers InezVerhey FransScheltens PhilipGraff CarolinePapenberg GoranGiedraitis VilmantasBoland AnneDeleuze Jean-FrançoisNicolas GaelDufouil CarolePasquier FlorenceHanon OlivierDebette StéphanieGrünblatt EdnaPopp JuliusGhidoni RobertaGalimberti DanielaArosio BeatriceMecocci PatriziaSolfrizzi VincenzoParnetti LucillaSquassina AlessioTremolizzo LucioBorroni BarbaraNacmias BenedettaSpallazzi MarcoSeripa DavideRainero InnocenzoDaniele AntonioBossù PaolaMasullo CarloRossi GiacominaJessen FrankFernandez VictoriaKehoe Patrick GavinFrikke-Schmidt RuthTsolaki MagdaSánchez-Juan PascualSleegers KristelIngelsson MartinHaines JonathanFarrer LindsayMayeux RichardWang Li-SanSims RebeccaDeStefano AnitaSchellenberg Gerard DSeshadri SudhaAmouyel PhilippeWilliams Julievan der Flier WiesjeRamirez AlfredoPericak-Vance MargaretAndreassen Ole AVan Duijn CorneliaHiltunen MikkoRuiz AgustínDupuis JoséeMartin EdenLambert Jean-CharlesKunkle BrianBellenguez Céline - Premature ovarian insuffiency (POI) is one of the main cause behind infertility. The genetic analysis of POI should be part of the clinical diagnostics, as several genes have been implicated in the genetic background of it. The aim of our study was to analyse the genetic background of POI in a Hungarian cohort. - Source: PubMed
Publication date: 2024/04/22
Illés AnettPikó HenriettÁrvai KristófDonka VeronikaSzepesi OlíviaKósa JánosLakatos PéterBeke Artúr - Despite intensive risk-based treatment protocols, 15% of paediatric patients with B-Cell Precursor Acute Lymphoblastic Leukaemia (BCP-ALL) experience relapse. There is urgent need of novel strategies to target poor prognosis subgroups, like PAX5 translocated. - Source: PubMed
Publication date: 2022/08/16
Fazio GraziaBresolin SilviaSilvestri DanielaQuadri ManuelSaitta ClaudiaVendramini ElenaBuldini BarbaraPalmi ChiaraBardini MichelaGrioni AndreaRigamonti SilviaGalbiati MartaMecca StefanoSavino Angela MariaPeloso AlbertoTu Jia-WeyBhatia SanilBorkhardt ArndtMicalizzi ConcettaLo Nigro LucaLocatelli FrancoConter ValentinoRizzari CarmeloValsecchi Maria GraziaTe Kronnie GeertruijBiondi AndreaCazzaniga Giovanni