Ask about this productRelated genes to: SIRT7 antibody
- Gene:
- SIRT7 NIH gene
- Name:
- sirtuin 7
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-20
- Date modifiied:
- 2014-11-19
Related products to: SIRT7 antibody
Related articles to: SIRT7 antibody
- Reproductive aging is an increasing health concern that affects family planning and overall well-being. While extensively studied in females, the mechanisms driving male reproductive aging remain largely unexamined. Here, we found that mammalian Sirtuin 7 sustains spermatogenesis in an age-dependent manner. Sirtuin 7 deficiency in mice increases histone H3 lysine 36 acetylation in spermatogonia and spermatocytes, a pattern also observed during natural aging, and leads to altered chromatin accessibility and increased vulnerability to genotoxic stress. Importantly, undifferentiated spermatogonia, required for continuous sperm production, become prematurely lost in Sirtuin 7 deficient mice and show increased genome damage accumulation during aging or environmental stress. These changes are concurrent with age-dependent defects in double-strand break repair and a meiotic delay. Taken together, our results indicate that Sirtuin 7 connects histone H3 lysine 36 acetylation epigenetic regulation to long-term genome stability in male germ cells, ensuring steady-state spermatogenesis during the lengthy male reproductive lifespan. - Source: PubMed
Publication date: 2026/04/28
Guitart-Solanes AnnaRomero MayraGamez-Garcia AndresFernández-Duran IreneNiedenberger Bryan AMadrid-Sandín CristinaSpears NorahRoig IgnasiGeyer Christopher BVaquero AlejandroSchindler KarenVazquez Berta N - Psoriasis is a chronic inflammatory disease characterized by epidermal hyperplasia and dermal T cell infiltration. Epidermal keratinocytes function not only as the primary targets of the inflammatory response but also play a pivotal role in initiating and maintaining the inflammatory state. Sirtuin 7 (SIRT7), an NAD-dependent protein deacetylase, is critical for various cellular processes, including proliferation, metabolic homeostasis, and inflammation. However, its role in psoriasis remains elusive. - Source: PubMed
Publication date: 2026/04/14
Luo YixinSu XiaoleiZhang ChenLiu ZhenhuaLi KangQiao PeiSu ChencanXiao ChunyingLi XiaChen JiaolingWang LeiGuo WeinanDang ErleWang GangLi Bing - Pancreatic neuroendocrine tumors (PanNETs) frequently exhibit loss or reduced expression of the tumor suppressor MEN1, a key regulator of tumor progression and DNA damage response (DDR). However, the upstream mechanisms driving MEN1 silencing remain unclear. Here, a pooled epigenetic CRISPR-Cas9 screen identified the NAD-dependent deacetylase SIRT7 as a critical suppressor of MEN1 expression. Mechanistically, SIRT7 interacts with DNMT1 and promotes catalytic activity-dependent recruitment of DNMT1 to the MEN1 promoter, leading to promoter hypermethylation and transcriptional repression. Clinically, SIRT7 is overexpressed in PanNET tissues and inversely correlates with MEN1 levels and patient prognosis. Genetic or pharmacologic inhibition of SIRT7 restored MEN1 expression, reduced MRN complex abundance, and impaired double-strand break repair. Graded MEN1 re-expression demonstrated a quantitative relationship between MRN levels, DNA repair efficiency, and radiosensitivity. Functionally, SIRT7 inhibition enhanced radiation-induced DNA damage and apoptosis in a partially MEN1-dependent manner and significantly suppressed tumor growth in patient-derived organoids and multiple independent xenograft models. Collectively, these findings define a catalytic activity-dependent SIRT7-DNMT1-MEN1 epigenetic axis that modulates DDR and radiosensitivity, supporting SIRT7 targeting as a strategy to improve radiotherapy efficacy in PanNETs. - Source: PubMed
Publication date: 2026/04/13
Jiang JianyunWang YanQin YiChen LuohaiXu XiaowuFan GuixiongJing DeshengWei MiaoyanYu XianjunXu JunfengJi ShunrongChen Jie - Innovative and affordable treatment options are required to combat obesity and its detrimental impact on health economics. Dapagliflozin (Dapa), an antidiabetic medication, promotes weight loss; however, the extent of weight reduction may be limited. Intermittent fasting (IF) is a dietary approach regarded as a cost-effective and readily accessible regimen. This study investigated the beneficial effects of Dapa, IF, and their combination on weight loss and metabolic derangements in high-fat diet (HFD)-induced obesity in rats. Male Sprague-Dawley rats were allocated into 6 groups: groups 1 (normal control) and 2 (drug control) were administered a normal chow diet, while the obesity groups 3, 4, 5, and 6 were subjected to HFD for 8 weeks. Rats in groups 4, 5, and 6 underwent a further 8-week treatment with Dapa (5 mg/kg, p.o) daily, IF (16/8), or a combination of both, respectively. The HFD group exhibited elevated anthropometric measurements and adiposity index. Upon histopathological examination, the HFD group showed adipocyte hypertrophy, hypercellularity, and possible necrosis, along with hepatic fat accumulation and elevated serum liver enzymes. The HFD group showed a downregulation of p-AMPK/SIRT1 and an upregulation of SIRT7, GPR43, and clock genes BMAL1, CLOCK, and CRY1 expression in adipose tissue, along with a drop in the gut microbiome diversity, serum short-chain fatty acids (SCFAs), POMC, and PYY levels. Dapa and IF combination demonstrated favorable outcomes over monotherapy, as evidenced by normalized anthropometric measurements, improved histopathological and biochemical derangements, regulated p-AMPK/SIRT1, SIRT7, and clock genes expression, and restored gut microbiome and SCFA levels. Conclusively, this study suggests the concurrent administration of Dapa and IF as a new, beneficial, cost-effective anti-obesity strategy. - Source: PubMed
Publication date: 2026/04/12
Senousy Mahmoud AAbo-Elmaaty Rana MohamedNabil Omar NesreenAbdelgawad Hanan M - - Source: PubMed
Publication date: 2026/04/09
Khidhir Karzan GSabir Dana KSalihi AbbasMiranda Benjamin H