Ask about this productRelated genes to: TLE1 antibody
- Gene:
- TLE1 NIH gene
- Name:
- TLE family member 1, transcriptional corepressor
- Previous symbol:
- -
- Synonyms:
- ESG1, GRG1, ESG
- Chromosome:
- 9q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-13
- Date modifiied:
- 2018-11-15
Related products to: TLE1 antibody
Related articles to: TLE1 antibody
- Primary renal synovial sarcoma (PRSS) is an extremely rare neoplasm that presents considerable diagnostic challenges due to its morphological overlap with other renal tumors. In this multicenter study, 23 PRSS cases with confirmed SS18::SSX rearrangements and 112 non-PRSS renal tumors were included. Clinicopathological features and immunohistochemical expression were evaluated. Diagnostic performance of individual markers and their combinations was assessed using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, and a practical diagnostic approach for PRSS was proposed. The cohort (n = 23) had a median age of 42.3 years with slight male predominance (56.5%). Most presented with loin pain, and the mean tumor size was 8.7 cm. After a mean follow-up of 25 months, 41.2% (7/17) died of disease. Histologically, 87% (20/23) of cases showed intersecting monophasic spindle-cell morphology with oval‑to‑spindle hyperchromatic nuclei, while 13% (3/23) were biphasic. Key immunohistochemical findings included positivity for SS18-SSX (56.5%), TLE1 (82.4%), BCL2 (75%), and EMA (25%), with reduced/mosaic INI1 expression in 73.9% of cases. SS18-SSX, TLE1, and INI1 formed the optimal diagnostic panel. The criterion of at least two positive or aberrant markers achieved the highest performance: accuracy 94.8%, sensitivity 69.6%, specificity 100%, PPV 100% and NPV 94.1%. Based on these findings, a practical diagnostic approach integrating morphology with SS18-SSX, TLE1, and INI1 immunohistochemistry was proposed. PRSS is a rare malignant tumor with a poor prognosis that presents significant diagnostic challenges. Our immunohistochemical panel (SS18-SSX, TLE1, INI1) enhances diagnostic accuracy and may assist in the triage of cases requiring molecular confirmation. - Source: PubMed
Publication date: 2026/06/29
Yang YuanzhongWang JiayuChen YaJin HongtaoCao YunYang ShicongZhang Yijun - While proteasomes are best known for eliminating defective proteins or turning off signaling pathways, they also enable crucial cellular activities. Critical among these, proteasomes allow cells to initiate gene expression, but underlying targets and regulatory mechanisms remain poorly understood. Here, we report that proteasomes drive the systemic degradation of repressive trans-cription factors to eject TLE/Groucho-family co-repressors from chromatin and thereby constantly free transcription start sites for activator binding. This circuitry requires the E3 ligase SCF , which modifies its targets dependent on presentation by TLEs, but independently of their identity. The continuous cycling of co-repressors off chromatin, as achieved by systemic turnover of a protein family, is essential for stem cells to translate developmental cues into lineage-specific gene expression, and it is disrupted by cancer mutations in that impair SCF -recruit-ment. We conclude that systemic degradation of repressive transcription factors establishes co-repressor dynamics required for genes expression and cell fate specification. - Source: PubMed
Publication date: 2026/06/18
Jevtić PredragWitus Samuel RMcCloud Devlon MYang ZhiJevtić Ana MilunovićRoh HeegwangRapé Michael - Myxoid epithelioid sarcoma is a rare morphologic variant of epithelioid sarcoma characterized by abundant myxoid stroma and frequent loss of SMARCB1/INI1 expression. Orbital involvement is exceptionally uncommon. We report a case of a SMARCB1-deficient malignant orbital neoplasm with features overlapping myxoid epithelioid sarcoma in a 61-year-old man presenting with visual disturbance. Imaging studies revealed a 2.5-cm medial orbital mass without evidence of another primary lesion. The tumor was excised without prior biopsy. Histologically, the lesion was predominantly composed of abundant myxoid stroma containing scattered atypical epithelioid, signet ring-like, and spindle cells, with focal fascicular proliferation infiltrating skeletal muscle. Immunohistochemically, tumor cells were positive for pan-cytokeratin, EMA, vimentin, and CD34, while negative for S100, ΔNp63 (p40), p63, SS18-SSX, and TLE1. Complete loss of SMARCB1/INI1 expression was observed in tumor cells. The overall findings suggested a SMARCB1-deficient malignant neoplasm showing substantial morphologic and immunophenotypic overlap with myxoid epithelioid sarcoma. This case highlights the diagnostic challenges posed by SMARCB1-deficient tumors arising in unusual anatomical sites and expands the clinicopathological spectrum of myxoid epithelioid sarcoma-like neoplasms involving the orbit. - Source: PubMed
Publication date: 2026/06/24
Hosaka MichikoKubo TerufumiYamashita KenSugawara TaroArihara YoheiWatabe HayatoYotsuyanagi TakatoshiTakada KohichiSugita ShintaroWatanabe Reiko - Synovial sarcoma (SS) is a rare, aggressive malignant neoplasm with a high rate of metastasis despite its indolent nature. A distinct SS18::SSX fusion oncogene characterizes SS. The monophasic subtype is the most common and consists of spindle cells. Due to its rarity and subtle clinical presentation, SS can be challenging to identify, leading to misdiagnosis or delays in treatment. The present case highlights the importance of awareness and vigilance among healthcare providers when encountering slow-growing, seemingly benign soft-tissue tumors. - Source: PubMed
Publication date: 2026/06/21
Diaz JohanSanchez ChristyFernandez VielkaRecine MonicaGangeri Natassja - Chronic obstructive pulmonary disease (COPD) is the primary cause of deaths related to respiratory diseases. Epigenetic modifications are crucial in the development of mammals, and any disruption to epigenetic regulation may result in disease. - Source: PubMed
Publication date: 2026/06/07
Xie JianpengHuang LinhuiChen XinWang Xilong