Ask about this productRelated genes to: OR13C5 antibody
- Gene:
- OR13C5 NIH gene
- Name:
- olfactory receptor family 13 subfamily C member 5
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-28
- Date modifiied:
- 2015-12-09
Related products to: OR13C5 antibody
Related articles to: OR13C5 antibody
- Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. - Source: PubMed
Sabater-Lleal MariaHuffman Jennifer Ede Vries Paul SMarten JonathanMastrangelo Michael ASong CiPankratz NathanWard-Caviness Cavin KYanek Lisa RTrompet StellaDelgado Graciela EGuo XiuqingBartz Traci MMartinez-Perez AngelGermain Marinede Haan Hugoline GOzel Ayse BPolasek OzrenSmith Albert VEicher John DReiner Alex PTang WeihongDavies Neil MStott David JRotter Jerome ITofler Geoffrey HBoerwinkle Ericde Maat Moniek P MKleber Marcus EWelsh PaulBrody Jennifer AChen Ming-HueiVaidya DhananjaySoria José ManuelSuchon Pierrevan Hylckama Vlieg AstridDesch Karl CKolcic IvanaJoshi Peter KLauner Lenore JHarris Tamara BCampbell HarryRudan IgorBecker Diane MLi Jun ZRivadeneira FernandoUitterlinden André GHofman AlbertFranco Oscar HCushman MaryPsaty Bruce MMorange Pierre-EmmanuelMcKnight BarbaraChong Michael RFernandez-Cadenas IsraelRosand JonathanLindgren Arne Gudnason VilmundurWilson James FHayward CarolineGinsburg DavidFornage MyriamRosendaal Frits RSouto Juan CarlosBecker Lewis CJenny Nancy SMärz WinfriedJukema J WouterDehghan AbbasTrégouët David-AlexandreMorrison Alanna CJohnson Andrew DO'Donnell Christopher JStrachan David PLowenstein Charles JSmith Nicholas L - Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients infected by RSV that needed hospitalization due to development of severe bronchiolitis. The Iberian sample (IBS) from The 1000 Genomes Project (1000G) was used as control group; all the association results were pseudo-replicated using other 1000G-European controls and Spanish controls. The study points to SNP rs199665292 in the olfactory receptor (OR) gene OR13C5 as the best candidate variant (P-value = 1.16 × 10; OR = 5.56). Genetic variants at HLA genes (HLA-DQA1, HLA-DPB1), and in the mucin 4 gene (MUC4) also emerge as susceptibility candidates. By collapsing rare variants in genes and weighing by pathogenicity, we obtained confirmatory signals of association in the OR gene OR8U1/OR8U8, the taste receptor TAS2R19, and another mucin gene (MUC6). Overall, we identified new predisposition variants and genes related to RSV infection. Of special interest is the association of RSV to olfactory and taste receptors; this finding is in line with recent evidence pointing to their role in viral infectious diseases. - Source: PubMed
Publication date: 2017/11/21
Salas AntonioPardo-Seco JacoboCebey-López MiriamGómez-Carballa AlbertoObando-Pacheco PabloRivero-Calle IreneCurrás-Tuala María-JoséAmigo JorgeGómez-Rial JoséMartinón-Torres Federico