Ask about this productRelated genes to: ZNF543 antibody
- Gene:
- ZNF543 NIH gene
- Name:
- zinc finger protein 543
- Previous symbol:
- -
- Synonyms:
- DKFZp434H055
- Chromosome:
- 19q13.43
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-12
- Date modifiied:
- 2018-11-23
Related products to: ZNF543 antibody
Related articles to: ZNF543 antibody
- Bromodomain and extracellular terminal (BET) family (including BRD2, BRD3, and BRD4) is considered to be a major driver of cancer cell growth and a new target for cancer therapy. Currently, more than 30 targeted inhibitors have shown significant inhibitory effects against various tumors in preclinical and clinical trials. However, the expression levels, gene regulatory networks, prognostic value, and target prediction of , , and in adrenocortical carcinoma (ACC) have not been fully elucidated. Therefore, this study aimed to systematically analyze the expression, gene regulatory network, prognostic value, and target prediction of , , and in patients with ACC, and elucidated the association between BET family expression and ACC. We also provided useful information on , , and and potential new targets for the clinical treatment of ACC. - Source: PubMed
Publication date: 2023/01/30
Situ YongliLiang QuanyanZeng ZiyingChen JvShao ZhengXu QinyingLu XiaoyongCui YongshiZhang JuyingLu LinglingDeng Li - Genetic studies of familial forms of Parkinson's disease (PD) have shown that the ZNF543 gene is a candidate gene that operates relevant to this disease. However, until now, there is no evidence for ZNF543 gene function in PD, and mechanisms resulting from its mutation have not been elucidated. Given the same genetic location of the ZNF543 gene with TRIM28 and their effects on PD pathogenesis, we surmised that ZNF543 might act as a transcription factor for TRIM28 gene expression. By knocking out the ZNF543 gene via the CRISPR/Cas9 editing platform, we assessed the functional effect of loss of expression of this gene on TRIM28 gene expression. Four sgRNAs with different PAM sequences were designed against two parts of the regulatory region of ZNF543 gene, and highly efficient disruption of ZNF543 expression in human neuroblastoma cell line was evaluated by polymerase chain reaction and T7 endonuclease assay. Moreover, evaluation of TRIM28 gene expression in ZNF543-knocked-out cells indicated a significant increase in TRIM28 gene expression, suggesting that ZNF543 probably regulates the expression of TRIM28. This approach offers a window into pinpointing the mechanism by which ZNF543 gene mutations mediate PD pathogenicity. - Source: PubMed
Publication date: 2022/04/25
Hashemabadi MohammadSasan HosseinaliAmandadi MojdehEsmaeilzadeh-Salestani KeyvanEsmaeili-Mahani SaeedRavan Hadi - Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by cognitive impairment and memory loss, for which there is no effective cure to date. In the past several years, numerous studies have shown that increased inflammation in AD is a major cause of cognitive impairment. This study aimed to reveal 22 kinds of peripheral immune cell types and key genes associated with AD. The prefrontal cortex transcriptomic data from Gene Expression Omnibus (GEO) database were collected, and CIBERSORT was used to assess the composition of 22 kinds of immune cells in all samples. Weighted gene co-expression network analysis (WGCNA) was used to construct gene co-expression networks and identified candidate module genes associated with AD. The least absolute shrinkage and selection operator (LASSO) and random forest (RF) models were constructed to analyze candidate module genes, which were selected from the result of WGCNA. The results showed that the immune infiltration in the prefrontal cortex of AD patients was different from healthy samples. Of all 22 kinds of immune cells, M1 macrophages were the most relevant cell type to AD. We revealed 10 key genes associated with AD and M1 macrophages by LASSO and RF analysis, including , , , , , , , , and . We verified these 10 genes by logistic regression and k-fold cross-validation. We also validated the key genes in an independent dataset, and found , , , , , , and were significantly different between the AD and healthy controls. Moreover, in the 5XFAD transgenic mice, the differential expression trends of , , , , and are consistent with them in independent dataset. Our results provided potential therapeutic targets for AD patients. - Source: PubMed
Publication date: 2022/01/01
Liu ChenmingZhang XiChai HuazhenXu SutongLiu QiuluLuo YupingLi Siguang - Obesity was established as a relevant modifiable risk factor in the onset and progression of colorectal cancer (CRC). This relationship could be mediated by an epigenetic regulation. - Source: PubMed
Publication date: 2018/05/01
Crujeiras Ana BMorcillo SonsolesDiaz-Lagares AngelSandoval JuanCastellano-Castillo DanielTorres EsperanzaHervas DavidMoran SebastianEsteller ManelMacias-Gonzalez ManuelCasanueva Felipe FTinahones Francisco J - Previously, a large proportion of the genetic components predisposing individuals to IgA nephropathy (IgAN) have been unidentified. Familial IgAN is enriched with genetic variations predisposing individuals to the disease. Whole exome sequencing is an effective way to explore disease-causing genes and gene variants. - Source: PubMed
Publication date: 2015/06/18
Liu RuihongHu BinLi QibinJing XiangyiZhong ChengChang YuLiao QijunLam Man FLeung Joseph C KLai Kar NWang Yiming