Ask about this productRelated genes to: YWHAB antibody
- Gene:
- YWHAB NIH gene
- Name:
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
- Previous symbol:
- YWHAA
- Synonyms:
- -
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-09-20
- Date modifiied:
- 2016-10-05
Related products to: YWHAB antibody
Related articles to: YWHAB antibody
- This study aims to explore the functions and mechanisms underlying the involvement of 14-3-3β in esophageal squamous cell carcinoma (ESCC). - Source: PubMed
Publication date: 2026/02/11
Hu Qing-HuaZhu Man-QinChen KuaiHuang Jin-ShiTao QiangGuo Zhi-Bin - Numerous studies have identified a close association between visceral adipose tissue mass (VAT) and neuropsychiatric disorders (NPDs). Both VAT and NPDs exhibit high heritability, yet their shared genetic architecture remains unclear. - Source: PubMed
Publication date: 2026/02/02
Xia JiangweiLi JiajianChen SiqiChang TianpengQian YuWu OuWu YangZhao YinanHao JunweiZhong Lianmei - In the pathogenesis of Alzheimer's disease (AD), amyloid-beta (Aβ) is widely recognized as a core pathological hallmark and an upstream factor contributing to cognitive decline. However, not all individuals with Aβ pathology inevitably develop cognitive impairment or progress to AD. To date, the key proteins associated with cognitive progression in Aβ-positive (A +) individuals have not been fully identified. This study aimed to identify such proteins in A + participants, defined by cerebrospinal fluid (CSF) Aβ levels and Aβ positron emission tomography (PET) imaging, using CSF proteomics. We analyzed 6,361 CSF proteins from 490 A + participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Baseline differences in protein expression were examined between the A + with AD dementia group and the A + non-demented group, which included cognitively normal (CN) and mild cognitive impairment (MCI) participants. Associations between dysregulated proteins and both cognitive progression and diagnostic conversion were investigated using linear mixed-effect (LME) and Cox proportional-hazard models, with a mean follow-up of 3.65 years. Functional enrichment was assessed through Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. We identified 61 dysregulated proteins, including 47 upregulated and 14 downregulated, in the A + with AD dementia group compared with the A + non-demented group. Of these, 39 key proteins (significantly associated with all five cognitive scales and diagnostic conversion) and 14 candidate proteins (associated with at least one cognitive measure) were linked to cognitive progression. Notably, 14-3-3 proteins (YWHAG, YWHAZ, YWHAB) were strongly associated with cognitive decline, particularly in the early stage of AD, and YWHAG, MMP10, and NEFH were associated with a higher risk of cognitive diagnostic conversion than classical CSF AD biomarkers. GO enrichment analysis revealed that these dysregulated proteins were significantly enriched in pathways related to cognition, learning, or memory. These findings may provide potential targets for early diagnosis and therapeutic intervention in AD. - Source: PubMed
Publication date: 2025/12/26
Liu MinHu He-YingFu YanChi Hao-ChenHuang Liang-YuTan LanHu Hao - Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and the lung is one of the most frequent metastatic sites for HCC. In this study, we aimed to identify a mild active substance in L. that can inhibit the pulmonary metastasis of HCC and reduce the drug resistance of clinical therapies. Further deepen the understanding of the anti-cancer functions of the mulberry active substances. In this study, we have screened and identified a flavonoid compound extracted from the root bark of the L. named Kuwanon A (KA). Our research demonstrated that KA directly targeted the YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and mediated its dimer dissociation. Thereby inhibiting the MAPK pathway and affecting downstream biological functions, including cell cycle arrest and migration/invasion inhibition. The experiment results proved that KA could inhibit the proliferation and metastasis of highly metastatic HCC cells both in vitro and in vivo. Additionally, when KA was combined with the clinical drug sorafenib, it exhibited a synergistic effect in inhibiting HCC cell proliferation, migration, and invasion. In conclusion, KA demonstrated a favorable anti-tumor effect in HCC cells. - Source: PubMed
Publication date: 2025/09/23
Xu JingyangChang HongboWang YongzhaoDu YiZhong LipingCui Hongjuan - Intrauterine growth restriction (IUGR) severely hinders the development of the livestock industry and impacts economic efficiency. MicroRNAs (miRNAs) participate in the epigenetic regulation of animal growth and development. Using IUGR pigs as a model, this study analyzed transcriptomic data from IUGR piglets to investigate the miRNA-mRNA regulatory network in their testes. Compared with NBW pigs, IUGR pigs exhibited reduced testicular volume, decreased weight, and abnormal testicular development. A total of 4945 differentially expressed mRNAs and 53 differentially expressed miRNAs were identified in IUGR testicular tissues, including 1748 downregulated and 3197 upregulated mRNAs, as well as 41 upregulated and 12 downregulated miRNAs. The integrated analysis of differentially expressed genes, miRNA target genes, and the miRNA-mRNA network revealed that IUGR may impair testicular development by disrupting cell cycle progression and apoptotic pathways, thereby hindering normal testicular cell growth. Furthermore, analysis of the miRNA-mRNA network indicated that miRNAs such as ssc-miR-23a, ssc-miR-29c, ssc-miR-193a-3p, and ssc-miR-574-3p could serve as potential marker miRNAs for IUGR testes, while YWHAZ, YWHAB, and PPP2CA may function as core target genes within this regulatory network. In conclusion, this study enhances our understanding of male reproduction in IUGR pigs and provides a theoretical foundation for preventing and treating IUGR-induced male reproductive disorders. - Source: PubMed
Publication date: 2025/08/24
Li JiaxinWang KaiMa JianfengSun LijunNiu LiliZhao YeChen LeiZhou LixinXue JiaZhou XiaofengWang YanShen LinyuanZhu LiGan Mailin