Ask about this productRelated genes to: TRAF6 antibody
- Gene:
- TRAF6 NIH gene
- Name:
- TNF receptor associated factor 6
- Previous symbol:
- -
- Synonyms:
- RNF85
- Chromosome:
- 11p12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-12
- Date modifiied:
- 2015-11-20
Related products to: TRAF6 antibody
Related articles to: TRAF6 antibody
- The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF-κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)-induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF-κB pathway and its dysregulation in ulcerative colitis (UC) remain unclear. Here, it is report that epithelial TRIM27 functions as an anti-inflammatory factor that inhibited intestinal inflammation in IECs in vitro and in epithelial Trim27 knockout mice in vivo. Mechanistically, TRIM27 destabilized IKKα and TRAF6 via polyubiquitination of IKKα at the K569 site and TRAF6 at the K489 site. In response to TNF-α, IKKβ phosphorylated TRIM27 at S173 to decrease TRIM27 expression by impairing its binding to ubiquitin-specific protease 7 (USP7) and USP7-mediated TRIM27 deubiquitination. Notably, overexpression of TRIM27 enhanced the anti-inflammatory effect of infliximab (IFX) in IECs. TRIM27 is downregulated in inflamed colons from UC patients and is associated with the therapeutic effect of IFX. Overall, this study identifies epithelial TRIM27 as a bona fide negative modulator of intestinal inflammation and USP7/TRIM27-IKK as a new double negative feedback mechanism of the NF-κB pathway, which supports the use of TRIM27 replenishment as a potential therapeutic strategy for UC. - Source: PubMed
Publication date: 2026/04/22
Xu WeiminHua ZhebinDai ZhujiangZhang ShashaJiang YihanGe WensongChen YingWeiWang ZhongchuanZhang BingLiu Chen-YingDu Peng - - Source: PubMed
Publication date: 2026/04/20
Ye ChunhuaLiu HuaMing ZhuYi QinjunXiang RongChen Yifu - This study aimed to assess the dose-dependent effect of DADLE and to explore its relationship with the TRAF6/NF-κB/NLRP3 pathway. - Source: PubMed
Liu LinwenSun YawuWu YinyanWang YangChen Wei - Thermal processing strongly influences the bioactivity of phytochemical-rich foods, but the mechanisms behind functional loss under different conditions are not well understood. We used honey-processed licorice as a model to explore the process-structure-function relationship by simulating the honey processing of four key compounds: isoliquiritigenin, liquiritin, glycyrrhizic acid, and 18β-glycyrrhetinic acid. UPLC-Q-TOF-MS/MS, molecular docking, dynamics simulations, DFT calculations, and RAW264.7 macrophage assays identified a narrow processing window where moderate glycosidic cleavage creates an optimal pool of fragments, while extended heating causes over-fragmentation. These fragments, but not over-cleaved ones, maintain multi-target engagement along the TLR4-MyD88-TRAF6-IKK/IκB-NF-κB signaling axis through a conserved 'anchor-clasp' motif, explaining why raw monomers are more effective than honey-processed ones in macrophages. Our findings provide a framework for optimizing thermal food processing to preserve the health benefits of functional ingredients. - Source: PubMed
Publication date: 2026/04/10
Jing WenhuiXu SijinLi CunbingLi YuxingLi XiaoyunSui HongFu Xueyan - Musculoskeletal dysfunction and compromised physical performance are prevalent complications observed in individuals diagnosed with cancer, frequently intensified by the administration of chemotherapy, radiotherapy, and extended periods of physical inactivity. Polyphenols (bioactive constituents derived from various plant sources) have exhibited significant anti-inflammatory, antioxidant, and anti-apoptotic characteristics that may serve to augment exercise interventions aimed at improving musculoskeletal recovery and rehabilitation outcomes. This review encapsulates the existing preclinical and clinical evidence regarding the synergistic effects of polyphenol supplementation in conjunction with structured exercise protocols in the context of cancer, with particular emphasis on underlying molecular mechanisms and functional outcomes. Prominent signaling pathways influenced by these combined therapeutic strategies include Wnt/β-catenin, PI3K/Akt, TNF-α/NF-κB, IL-4/STAT6, and TGF-β1/TRAF6, which are integral to the regulation of inflammation, apoptosis, muscle metabolism, and tissue remodeling. Preclinical investigations conducted using rodent cancer models consistently reveal that polyphenols such as curcumin, resveratrol, and genistein, significantly enhance the efficacy of both aerobic and resistance exercise concerning tumor suppression, muscle preservation, and modulation of molecular pathways. Clinical evidence, although scarce, suggests potential enhancements in muscular strength, endurance, and recovery when polyphenolic compounds are utilized in conjunction with exercise rehabilitation, particularly among individuals undergoing oncological treatment. Despite these encouraging results, variability in dosing regimens, formulations, timing, and participant demographics constrains the generalizability of the findings. Subsequent research endeavors should prioritize the development of standardized polyphenolic preparations, refined exercise protocols, and clinically relevant functional outcomes to establish evidence-based clinical guidelines. The integration of polyphenols with exercise represents an auspicious non-pharmacological approach to augment musculoskeletal function and enhance quality of life in the context of cancer rehabilitation. - Source: PubMed
Publication date: 2026/04/01
Li YuleiGuan Xiujuan