Ask about this productRelated genes to: ZNF512 antibody
- Gene:
- ZNF512 NIH gene
- Name:
- zinc finger protein 512
- Previous symbol:
- -
- Synonyms:
- KIAA1805
- Chromosome:
- 2p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-19
- Date modifiied:
- 2016-10-05
Related products to: ZNF512 antibody
Related articles to: ZNF512 antibody
- To investigate the genetic relationship between irritable bowel syndrome (IBS) and non-alcoholic fatty liver disease (NAFLD). - Source: PubMed
Publication date: 2025/12/15
Hong JundongJi RuiWang PeichengHuang FengmingZhang FanZhou YanlinLv Bin - African swine fever virus (ASFV) is a large double-stranded DNA virus that poses a significant threat to the global pig industry. Currently, our understanding of ASFV biology remains limited, as there is a lack of suitable cell lines to support its propagation and analysis. Here, we optimized a wild boar lung cell line to increase its susceptibility to ASFV, followed by temporally integrated transcriptomic and proteomic analyses of ASFV infection. Multiomics analysis revealed more than 17,000 genes and 5100 proteins, with 1594 differentially expressed genes (DEGs) and 923 differentially expressed proteins (DEPs) identified. Temporal dynamics revealed stage-specific host modulation: early-phase DEPs orchestrated metabolic reprogramming and transmembrane transport via the solute carrier superfamily (e.g., SLC25A, SLC30A, and SLC44A2), whereas the late infection phase featured concurrent upregulation of innate immune effectors (e.g., Mx1, OAS1, ISG15, and TRIM21) and suppression of apoptosis inhibitors (e.g., TMEM192, PDCD4, and DPP9), suggesting synchronized antiviral activation and apoptotic regulation. Unexpectedly, siRNA-mediated knockdown of key DEGs or DEPs involved in antiviral immunity, interferon signalling, DNA repair, genome stability, immune regulation, the inflammatory response and vesicular transport did not significantly affect viral replication. Only knockdown of the genes STX17 and ZNF512 significantly impaired ASFV replication. This systematic investigation provides a comprehensive framework for further studies of ASFV-host interactions, identifies candidate host dependency/support factors and establishes critical groundwork for the development of targeted antiviral interventions and next-generation vaccine platforms. - Source: PubMed
Publication date: 2025/10/14
Wang HuaYe MiaomiaoWeng WenlianWu JiajunQu YajinGao PengZhang YongningZhou LeiGe XinnaGuo XinHan JunYang Hanchun - Lymph node metastasis (LNM) in cervical cancer is a critical determinant of the disease progression and prognosis. Elucidating its molecular mechanisms and identifying specific biomarkers are crucial for optimizing treatment. DIA-based quantitative proteomic sequencing was conducted on 49 cervical cancer patients. We screened differentially expressed proteins and performed functional enrichment, pathway scoring, time-series analysis, protein interaction studies, and integrated proteomic and TCGA transcriptomic data to identify biomarkers. 56 genes showed consistent expression trends, with 2 upregulated (SERPINB5, FABP5) and 54 downregulated (including ZNF512). Novel findings include activation of unsaturated fatty acid/steroid biosynthesis and inhibition of cell junction pathways during progression. Lymphovascular space invasion (LVSI) precedes LNM, but a subset of LNM cases lacks LVSI and exhibits a unique cholesterol metabolism activation. SERPINB5, FABP5, and ZNF512 were validated as potential prognostic and LNM-predictive biomarkers. DIA proteomics characterized cervical cancer lymph node metastasis, revealing molecular changes and potential biomarkers and offering new insights into its biological mechanisms. - Source: PubMed
Publication date: 2025/09/11
Hao YipingLiu QingqingWang BingyuZhang WenjingJiao XinlinZhang TengCui Baoxia - Adipogenic differentiation stands as a crucial pathway in the range of differentiation options for mesenchymal stem cells (MSCs), carrying significant importance in the fields of regenerative medicine and the treatment of conditions such as obesity and osteoporosis. However, the exact mechanisms that control the adipogenic differentiation of MSCs are not yet fully understood. - Source: PubMed
Publication date: 2024/08/29
Dai MiaomiaoHong WeishengOuyang Yi - Pericentric heterochromatin is a critical component of chromosomes marked by histone H3 K9 (H3K9) methylation. However, what recruits H3K9-specific histone methyltransferases to pericentric regions in vertebrates remains unclear, as does why pericentric regions in different species share the same H3K9 methylation mark despite lacking highly conserved DNA sequences. Here we show that zinc-finger proteins ZNF512 and ZNF512B specifically localize at pericentric regions through direct DNA binding. Notably, both ZNF512 and ZNF512B are sufficient to initiate de novo heterochromatin formation at ectopically targeted repetitive regions and pericentric regions, as they directly recruit SUV39H1 and SUV39H2 (SUV39H) to catalyse H3K9 methylation. SUV39H2 makes a greater contribution to H3K9 trimethylation, whereas SUV39H1 seems to contribute more to silencing, probably owing to its preferential association with HP1 proteins. ZNF512 and ZNF512B from different species can specifically target pericentric regions of other vertebrates, because the atypical long linker residues between the zinc-fingers of ZNF512 and ZNF512B offer flexibility in recognition of non-consecutively organized three-nucleotide triplets targeted by each zinc-finger. This study addresses two long-standing questions: how constitutive heterochromatin is initiated and how seemingly variable pericentric sequences are targeted by the same set of conserved machinery in vertebrates. - Source: PubMed
Publication date: 2024/07/03
Ma RunzeZhang YanZhang JingZhang PinqiLiu ZeqiFan YimingWang Hao-TianZhang ZhuqiangZhu Bing