Ask about this productRelated genes to: TRHR antibody
- Gene:
- TRHR NIH gene
- Name:
- thyrotropin releasing hormone receptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2016-02-01
Related products to: TRHR antibody
Related articles to: TRHR antibody
- : The aim of this pilot study was to evaluate the hierarchical contribution of individual genetic polymorphisms to the variability of autonomic regulation parameters and respiratory function in athletes of different sport specializations using Classification and Regression Tree (CRT) analysis. : The study included athletes divided into two groups: hockey players ( = 48) and martial artists ( = 43). Heart rate variability (LF, HF) parameters and spirometric indices (FEV) were assessed. Genetic analysis included 8 single nucleotide polymorphisms (SNPs): IL6 rs1800795, VDR rs731236, KCNJ11 rs5219, ADRB2 rs1042713, ADRB2 rs1042714, TRHR rs16892496, MSTN rs1805086, UCP3 rs1800849. : In martial artists, the main predictors were genes responsible for adrenoreceptor sensitivity (ADRB2) and neuroimmune interactions (IL6). In hockey players, the most significant predictors were genes involved in muscle growth (MSTN), energy metabolism (UCP3), and neuroendocrine regulation (TRHR). These findings indicate that similar resting HRV parameters in athletes from different sports may be associated with different genetic polymorphisms, reflecting sport-specific physiological adaptations to training loads. : The results highlight the sport-specific nature of genetic determinants of autonomic regulation. In martial artists, genes related to the immuno-adrenergic axis (IL6, ADRB2) appear to play a dominant role, whereas in hockey players neuroendocrine, muscle-metabolic, and mitochondrial factors (TRHR, MSTN, UCP3) demonstrate greater influence. The observed interactions between genotypes and FEV emphasize the importance of transitioning from generalized approaches toward personalized monitoring strategies in sports science. - Source: PubMed
Publication date: 2026/04/21
Bacheva IrinaIbrayeva LyazatRybalkina DinaKadyrova IrinaZhumagaliyeva Diana - Intramuscular fat (IMF) is a key determinant of beef sensory quality. In this study, 60 24-month-old Yanbian yellow cattle (n = 30 per group), reared under standardized environmental and dietary conditions, were categorized into high-IMF (HM) and low-IMF (LM) groups. HM beef exhibited significantly higher IMF (P < 0.05), increased monounsaturated fatty acids, and reduced saturated fatty acids compared to LM. Integrated transcriptomics and non-targeted metabolomics (n = 8 per group) revealed that IMF deposition is associated with a dual-layered regulatory framework: an upstream signaling layer (comprising PPAR, PI3K-Akt, and mTOR pathways) and a downstream metabolic execution layer (lysine degradation and cholesterol metabolism). Weighted Gene Co-expression Network Analysis (WGCNA) identified Acadm and Elovl6 as candidate hub genes within these networks. Furthermore, 9-hydroxyoctadecanoic acid (9-HODE) was identified as a differentially abundant metabolite; 100-ns molecular dynamics simulations suggested its high-affinity binding to the Thyrotropin-releasing hormone receptor (TRHR) receptor as a potential mechanism for lipid accumulation. These findings provide important biological insights and a mechanistic basis for understanding the molecular regulation of marbling in Yanbian yellow cattle. - Source: PubMed
Publication date: 2026/04/17
Sun BinWang HaowenYu JiaXin XuanyingPark SungkwonChoi Seong-HoYan ChangguoLi Xiangzi - The eastern and northern parts of Xinjiang are the main camel breeding areas in the region. Currently, there is a lack of systematic comparative genetic studies of local populations with significant phenotypic differences at the whole-genome level. Previous research has shown significant differences in milk production traits between Bactrian camels in the eastern and northern regions of Xinjiang. To further elucidate the genetic differences between the Bactrian camel populations in these two areas and the molecular basis of their lactation traits, this study selected 106 Bactrian camels—55 from three camel farms in the northern region and 51 from one farm in the eastern region—for whole-genome resequencing. - Source: PubMed
Publication date: 2026/03/30
Li YongqingCai ShudongTulafu HanikeziLiu ShihaoLin ChangchunWu WeiweiHuang Juncheng - Hypothyroidism is a condition marked by inadequate thyroid hormone production. It is typically treated with Levothyroxine, which, despite its effectiveness, can cause adverse effects on metabolism and the cardiovascular system. In this study, an in silico approach was used to screen phytochemicals from , , and for their potential to activate the thyroid receptor. A total of 439 compounds were docked against Thyroid Receptor Beta 1 (TRβ1) and Thyrotropin-Releasing Hormone Receptor (TRHR) using AutoDock Vina. Among them, valoneic acid dilactone, curcumin III, taxifolin, luteolin, lophenol, and stigmastanol were identified from the three plants as performing better than others. These compounds were further evaluated with ADMET predictions and molecular dynamics simulations to assess their drug-like properties and stability. Lophenol from showed the highest binding affinity to TRβ1 (-13.62 kcal/mol) with an inhibition constant of 0.1037 nM, surpassing levothyroxine (-11.60 kcal/mol and 6.63 nM). Also, stigmastanol from showed the highest binding affinity to TRHR (-8.71 kcal/mol) with an inhibition constant of 415 nM, surpassing levothyroxine (-7.64 kcal/mol and 2530 nM). However, the two compounds exhibited some unfavourable ADMET properties that could be improved through formulation science. Curcumin III and taxifolin demonstrated favourable ADMET properties, including optimal solubility, lipophilicity, and polar surface area, suggesting good oral bioavailability. Molecular dynamics simulations were carried out using Desmond. The results revealed that curcumin III, lophenol, and taxifolin maintained strong stability, with RMSD values of 1.70 ± 0.005 Å, 2.17 ± 0.012 Å, and 2.50 ± 0.014 Å, respectively, for TRβ1, and RMSD values of 3.82 ± 0.014 Å, 4.29 ± 0.019 Å, and 3.31 ± 0.017 Å, respectively, for TRHR. This study identified Curcumin III from and taxifolin from as promising natural compounds for the treatment of hypothyroidism. Further validation through , , studies is recommended. - Source: PubMed
Publication date: 2026/02/16
Oyinloye Babatunji EmmanuelAdewale Adetola IbukunoluwaAdeyemi Shalom OluwafunkeFajana Omotola MarthaOlusola Olutosin SamuelOyinloye Oluwatoyin MaryAyeni Aderonke MoyosolaAkawa Ayodeji BenjaminIdowu Olajumoke TolulopeIbikunle Austine IdowuOlojo Folake OlayinkaAjiboye Basiru Olaitan - Thyrotropin-releasing hormone (TRH) is a highly conserved tripeptide classically associated with regulation of the hypothalamic-pituitary-thyroid axis; however, TRH and its receptors are also widely distributed in peripheral metabolic tissues. While TRH has been implicated in glucose homeostasis in mammals, the developmental expression, tissue distribution, and sex-dependent metabolic roles of the TRHergic system in zebrafish remain poorly defined. Here, we characterized the TRHergic system in zebrafish (Danio rerio) by integrating bioinformatic analyses with developmental and adult expression profiling in both sexes, together with functional assessment under hyperglycemic conditions. TRHergic components - including pre proTRH, TRH receptor isoforms, and the TRH-degrading enzyme - were structurally conserved and dynamically expressed during early development, with trh-r1b displaying the most pronounced developmental changes. In adults, these genes exhibited broad central and peripheral expression with marked sex-specific patterns. In vivo, exogenous TRH reduced blood glucose levels in hyperglycemic males but not females. This effect was not associated with a direct insulinotropic response, supporting a modulatory role for TRH in metabolic regulation, likely involving peripheral tissues such as the pancreas and liver. Together, these findings establish zebrafish as a valuable vertebrate model for studying sex-dependent metabolic functions of the TRHergic system, particularly in the context of sex-dependent regulation of glucose homeostasis. - Source: PubMed
Publication date: 2026/04/02
Díaz-Ortegón DavidOrozco AureaPech-Pool Santiago MGarcía-Gutierrez María CarlotaLazcano Iván