Ask about this productRelated genes to: CHRNA2 antibody
- Gene:
- CHRNA2 NIH gene
- Name:
- cholinergic receptor nicotinic alpha 2 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-11
- Date modifiied:
- 2016-10-05
Related products to: CHRNA2 antibody
Related articles to: CHRNA2 antibody
- In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an all-or-none manner in CA1-PYRs recorded in acute hippocampal slices from mice of either sex. Plateaus were initially resistant to inhibition but became increasingly susceptible to termination as they progressed. Two subtypes of dendrite-targeting oriens-lacunosum moleculare (OLM) interneurons, accessed in transgenic mice based on the expression of the genes or (OLM and OLM, respectively), could terminate plateau potentials. OLM generated slower postsynaptic currents that terminated plateaus more effectively than OLM Voltage-gated Ca channels (VGCCs) were necessary for plateaus, which were prolonged by blocking small-conductance Ca-activated K channels (SK). A single-compartment model with these two conductances recapitulated core experimental findings and provided a mechanistic explanation for terminations. Plateaus arose from VGCCs maintained in the active state by sustained Ca influx, a positive feedback loop that was quasi-balanced by I Inhibition terminated plateaus by driving the membrane potential below a dynamic threshold to deactivate VGCCs and end the positive feedback loop. Similar all-or-none termination dynamics were observed for plateaus evoked under cholinergic modulation. Lastly, two-photon Ca imaging showed that plateaus evoke large dendritic Ca transients that were graded by terminations. Overall, our results demonstrate how the feedback inhibitory circuit interacts with intrinsic cellular mechanisms to regulate plateau potentials and shape dendritic Ca signals in CA1-PYRs. Plateau potentials are critical biophysical events that drive memory-related synaptic plasticity in the hippocampus, yet their underlying regulatory mechanisms remain incompletely understood. Here, we reveal that synaptic inhibition can abruptly terminate plateaus in CA1 pyramidal neurons. This all-or-none termination results from a nonlinear interaction between voltage-gated Ca2+ channels and SK channels. Using intersectional genetics, we identify two dendrite-targeting interneuron subtypes that differentially modulate plateau duration. Two-photon Ca2+ imaging further shows that plateau termination converts these binary events into graded dendritic Ca2+ signals. Overall, these results demonstrate that feedback inhibition regulates the duration of plateaus, adding a critical layer of control over dendritic computation. - Source: PubMed
Publication date: 2026/04/17
Vaasjo Lee OKotermanski Shawn EPatel TiyaShi Hengyue JMachold RobertChamberland Simon - Prostate cancer (PRAD/PCa) is a leading malignancy in men, with high incidence and mortality rates globally. Although treatments like androgen deprivation therapy (ADT) and chemotherapy have advanced, the prognosis for advanced or metastatic PCa remains unfavorable. Post-translational modifications (PTMs), particularly protein palmitoylation, have emerged as critical regulators of cancer progression and potential therapeutic targets. This study investigates the features of palmitoylation-related genes (PRGs) in PRAD, their links to immune infiltration, and potential therapeutic applications. - Source: PubMed
Publication date: 2026/01/26
Wang MingchaoDing YimingGao Lei - Psychoactive substance use (PSU) and cancer are frequently observed comorbidities that have reciprocal influences and shared behavioral traits of the affected patients. While, e.g., nicotine and alcohol are major carcinogens in the etiology of lung and head and neck cancers, little is known about a shared overarching genetic architecture of PSU and cancer that may predispose individuals to both illnesses. - Source: PubMed
Publication date: 2026/02/05
Song JiahangLi PengzhuCanis MartinUnger KristianHaas Nikolaus AlexanderGires Olivier - Pneumonia risk is influenced by demographics, chronic disease burden, lifestyle, and environmental factors. Despite previous genetic studies, the impact of host genetics on pneumonia, particularly within specific patient groups, remains unclear. - Source: PubMed
Publication date: 2026/01/23
Heikkilä AnniSliz EevaVäyrynen SaraReis KadriElnahas Abdelrahman GReigo AnuEsko Tõnu Kettunen JohannesHautala Timo - In the CA1 hippocampus, pyramidal cells (PCs) can be classified as deep or superficial based on their radial position within the stratum pyramidale. Deep and superficial PCs form biased circuits with perisomatic-targeting PV+ basket cells, but it is unknown if such cell-type-specific circuit motifs extend to dendrite-targeting interneurons. Using male and female mice, we investigated synaptic connectivity and physiology in brain slices from four transgenic lines thought to capture distinct subsets of interneurons: SST-IRES-Cre, Nkx2.1-Cre, Chrna2-Cre, and Htr3a-GFP. First, we found that oriens-lacunosum moleculare (OLM) cells captured by the Chrna2-Cre line are a subset of Htr3a-GFP+ cells in the hippocampus. This novel finding is consistent with previous work showing Nkx2.1-Cre OLM cells are distinct from both Chrna2-Cre and Htr3a-GFP+ OLM cells. Indeed, in paired whole-cell recordings, Nkx2.1-Cre+ interneurons in the stratum oriens, but not Chrna2-Cre+ or Htr3a-GFP+ cells, received more excitatory synaptic connections from superficial PCs relative to deep PCs. Next, we expressed channelrhodopsin in interneurons to investigate inhibition along the proximal and distal dendrites of PCs. We found that superficial PCs received stronger inhibition along their proximal dendrites than deep PCs from SST+ interneurons. Furthermore, this circuit motif was dependent on the layer but not PC projection class. Finally, Chrna2-Cre OLM cells provided stronger inhibition to the distal dendrites of deep PCs relative to superficial PCs. Our data reveal that superficial and deep PCs engage in cell-type-specific circuits with dendrite-targeting interneurons. Furthermore, they support that Nkx2.1-Cre OLM cells and Chrna2-Cre/Htr3a-GFP OLM cells are distinct subtypes that form unique circuits in CA1. - Source: PubMed
Publication date: 2025/12/03
Johantges Aidan CHanson Meretta AMarshall Alec HSafa AlirezaPayne Emily KHariths Neil RBibi NoorWester Jason C