Ask about this productRelated genes to: PMCH antibody
- Gene:
- PMCH NIH gene
- Name:
- pro-melanin concentrating hormone
- Previous symbol:
- -
- Synonyms:
- MCH
- Chromosome:
- 12q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-08
- Date modifiied:
- 2015-11-23
Related products to: PMCH antibody
Related articles to: PMCH antibody
- Background Oral potentially malignant disorders (OPMDs) represent precursor conditions that carry an elevated probability of progressing to oral squamous cell carcinoma (OSCC). Despite ongoing research efforts, identifying dependable, non-invasive markers that can detect early molecular changes linked to malignant conversion continues to present a significant clinical obstacle. Objective To evaluate the diagnostic utility of salivary inflammatory cytokines (IL-10 and IL-17) and microRNAs (miR-21, miR-138, and miR-184) in healthy individuals, patients with OPMDs, and patients with OSCC, and to assess the performance of a combined biomarker panel for oral cancer clinical stratification. Methods A cross-sectional analytical study was conducted involving 150 participants categorized into healthy controls (n=50), OPMD patients (n=50), and histopathologically confirmed OSCC patients (n=50). Salivary IL-10 and IL-17 concentrations were quantified using enzyme-linked immunosorbent assay (ELISA), whereas miR-21, miR-138, and miR-184 expression levels were measured using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Relative miRNA expression was calculated using the 2^-ΔΔCt method. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Results Significant alterations in salivary cytokine and microRNA expression were observed across the disease spectrum. miR-21 and miR-184 demonstrated progressive upregulation, whereas miR-138 showed progressive downregulation from healthy controls to OPMD and OSCC patients (all p<0.001). Both IL-10 and IL-17 were significantly elevated in OPMD and OSCC patients compared with healthy controls (both p<0.001). Biomarker expression profiles were significantly associated with dysplasia severity and tumor stage. Among individual biomarkers, miR-138 demonstrated the highest diagnostic accuracy (AUC=0.84), followed by IL-17 (AUC=0.82), miR-21 (AUC=0.80), miR-184 (AUC=0.76), and IL-10 (AUC=0.74). The combined cytokine-microRNA panel achieved superior performance, with an AUC of 0.93, sensitivity of 90%, and specificity of 88%. Conclusions The findings support the potential utility of integrated salivary biomarker profiling as a non-invasive approach for early detection, clinical stratification, and disease monitoring in oral carcinogenesis. The combined biomarker panel highlights the potential of integrated salivary diagnostics for improving the non-invasive detection and clinical assessment of OPMDs and OSCC. - Source: PubMed
Publication date: 2026/07/18
George BeenaKharat ShitalPrakash RoopanDanda Omkar Eswara BRaj RachnaUpadhyay Chintan MSaiyad Sajidali S - Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder associated with accelerated atherosclerosis and increased cardiovascular morbidity. Atherogenic indices derived from routine lipid parameters have emerged as potential markers of cardiovascular risk; however, their relationship with disease activity in RA remains incompletely understood, particularly in Indian populations. - Source: PubMed
Publication date: 2026/07/07
Roy RajeevAnadkat HarshMalik Tazean ZahoorParmar PoojaSaiyad Sajidali SChavda Grishma HEkambaram GnanadesiganPadmavathi PChatterjee Biswas Prasanta - Background Robotic-assisted total knee arthroplasty (RA-TKA) has emerged as an innovative technology aimed at improving surgical precision and optimizing postoperative outcomes. However, whether these technical advantages translate into meaningful clinical benefits compared with conventional total knee arthroplasty (C-TKA) remains uncertain. Objective To compare early postoperative functional recovery (primary outcome) and perioperative outcomes, complications, revision surgery, and patient satisfaction (secondary outcomes) over 12 months in patients undergoing primary unilateral total knee arthroplasty (TKA) using robotic-assisted or conventional techniques. Methods This retrospective cohort study included 301 patients who underwent primary TKA at a specialized orthopedic center over a two-year period. Of these, 87 patients underwent RA-TKA and 214 underwent C-TKA. Baseline demographic and clinical characteristics were comparable between groups. Perioperative outcomes, patient-reported outcome measures, complications, and satisfaction rates were evaluated. Multivariable linear regression and propensity score matching (1:2 nearest-neighbor matching) were performed to identify independent predictors of recovery and reduce selection bias. Results Robotic-assisted TKA was associated with significantly longer operative time (108.4 ± 14.2 vs. 88.6 ± 11.5 minutes; p<0.001) but demonstrated lower blood loss (255 ± 92 vs. 289 ± 105 mL; p=0.03), reduced postoperative hemoglobin decline (1.9 ± 0.7 vs. 2.2 ± 0.8 g/dL; p=0.01), and shorter hospital stay (4.2 ± 1.1 vs. 4.8 ± 1.3 days; p=0.01). Statistically significant improvements in early functional outcomes were observed in the robotic cohort at 6 weeks and 3 months; however, none of these differences exceeded established minimal clinically important difference (MCID) thresholds. At 12 months, functional outcomes were comparable between groups. Complication rates, revision surgery, and patient satisfaction did not differ significantly. Robotic-assisted TKA remained an independent predictor of improved three-month Knee Society Score following multivariable adjustment and propensity score matching. Conclusions RA-TKA provides superior early postoperative recovery, reduced perioperative morbidity, and shorter hospitalization compared with conventional TKA. No statistically significant differences were observed in complications or one-year clinical outcomes, although the study was underpowered to detect small differences in rare adverse events. - Source: PubMed
Publication date: 2026/07/03
Kumar Garg AnkitKarpetee Anil KumarDiwakar RaviRasheed HishanilSanmugam Kischentaran RPurohit PriyankaSaiyad Sajidali S - Background and objective Carbapenem-resistant Enterobacterales (CRE) have emerged as a major global public health threat, driven by the rapid dissemination of carbapenemase genes that compromise the efficacy of last-line antimicrobial agents. Comprehensive characterization of these mechanisms is essential for informing antimicrobial stewardship and infection-control strategies. The objective of this study was to investigate the molecular mechanisms underlying carbapenem resistance among clinical Enterobacterales isolates, with particular emphasis on carbapenemase genes and outer membrane porin expression alterations. Methods A retrospective cross-sectional study was conducted on 120 non-duplicate CRE isolates recovered from clinical specimens at a tertiary care hospital in Rajasthan, India, between January 2024 and December 2025. Species identification was performed using MALDI-TOF mass spectrometry, while antimicrobial susceptibility testing and carbapenem minimum inhibitory concentration (MIC) determination were carried out according to CLSI guidelines. Carbapenemase production was assessed using the Carba NP test. PCR was used to detect major carbapenemase and extended-spectrum β-lactamase (ESBL) genes. Outer membrane porin expression was evaluated by SDS-PAGE with densitometric analysis. Results accounted for the majority of isolates (75.0%), and most originated from intensive care units (54.2%). Carbapenemase activity was detected in 85.0% of isolates, while 87.5% harbored at least one carbapenemase gene. The most prevalent genes were bla_NDM (50.0%), followed by bla_KPC (16.7%) and bla_OXA-48-like (16.7%). ESBL genes were highly prevalent, particularly bla_CTX-M (79.2%). A marked reduction in OmpK36 expression was observed in 62.5% of isolates, and concurrent OmpK35/OmpK36 reduction occurred in 25.0%. Isolates with both carbapenemase genes and porin expression reduction demonstrated higher imipenem and meropenem MICs compared with carbapenemase-positive isolates without porin reduction (Mann-Whitney U test: for imipenem, U = 1420, Z = -5.02, p < 0.001; for meropenem, U = 1385, Z = -5.18, p < 0.001). Conclusions Carbapenem resistance in clinical Enterobacterales is strongly associated with carbapenemase production, particularly bla_NDM and bla_KPC, and is augmented by reduced outer membrane porin expression. These findings highlight the importance of integrating molecular diagnostics with routine susceptibility testing to guide antimicrobial stewardship and infection-control interventions. - Source: PubMed
Publication date: 2026/06/14
Suresh PavithraaR MuthamizhveenaPrabhu Guruswamy NarayananManish ManchireddyGusani JigarKumar P U DipinSaiyad Sajidali S - Acute poisoning is a severe global public health issue that involves injury or death caused by exposure to an exogenous substance through any route. This study evaluated the most common poisons, reasons for poisoning, clinical management of poisoning cases, and their associated outcomes. One-year prospective cohort study executed at an academic medical center in Sindh, Pakistan. The predictors of outcomes are examined using a binary logistic regression model. Among 1404 enrolled patients, the majority were male (57.1%), aged 16-30 years (63.2%) and married (77.6%). Organophosphate compounds (42.8%) were the primary reasons for poisoning. Clinical manifestations as abnormalities in blood pressure (AOR = 1.76; 95% CI: 1.04-2.97; p = 0.034), abnormal consciousness (AOR = 10.41; 95% CI: 5.91-18.35; p < 0.001), dyspnea (AOR = 3.20; 95% CI: 1.72-5.96; p < 0.001), bronchorrhea (AOR = 1.99; 95% CI: 1.06-3.74; p = 0.032) and salivation (AOR = 2.70; 95% CI: 1.38-5.29; p = 0.004) were associated with higher odds of death. Symptomatic management was achieved through the administration of proton pump inhibitors (89.0%) and antidotes, such as pralidoxime (49.9%). The findings highlight the need for stricter regulation of organophosphate storage and sales, alongside community awareness campaigns. Establishing regional poison and antidote centers, ensuring early recognition of clinical manifestations, and implementing standardized management protocols may reduce mortality risk. - Source: PubMed
Publication date: 2026/06/27
Muhammad ShaibAlmani Khalida FaryalMughal Ubed-Ur-RehmanIshaqui Azfar AtharKhaskheli Muhammad SalehSultana RaziaQureshi AliAlam ShoaibKumar Narendar