Ask about this productRelated genes to: TNFRSF10A antibody
- Gene:
- TNFRSF10A NIH gene
- Name:
- TNF receptor superfamily member 10a
- Previous symbol:
- -
- Synonyms:
- DR4, Apo2, TRAILR-1, CD261, TRAILR1
- Chromosome:
- 8p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2018-01-25
Related products to: TNFRSF10A antibody
Related articles to: TNFRSF10A antibody
- Accurate biomarkers that reflect disease activity, severity, and molecular pathophysiology in multiple sclerosis (MS) remain an unmet diagnostic need. We compared the performance of the established biomarkers, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), with emerging candidates in CSF and serum. - Source: PubMed
Publication date: 2026/04/23
Oechtering JohannaSchaedelin Sabine AnnaMaleska Maceski AleksandraStein KerstinGenc NafiyeEinsiedler MaximilianBenkert PascalWillemse ElineDerfuss Tobias JFischer-Barnicol BettinaD'Souza MarcusRegeniter AxelHu WayneQureshi FerhanFinkener SebastianMueller StefanieHoepner RobertLalive Patrice HPot CarolineGobbi ClaudioZecca ChiaraRoth PatrickWiendl HeinzLünemann Jan DKappos LudwigGranziera CristinaLeppert DavidKuhle Jens - To investigate the role of ( in chronic central serous chorioretinopathy (cCSCR), polypoidal choroidal vasculopathy (PCV), and neovascular age-related macular degeneration (nAMD). - Source: PubMed
Publication date: 2026/03/17
Chen Zhen JiYu JunNg Danny S CHo MaryZhu XintianBrelen Marten EYoung Alvin LYam Jason CTham Clement CPang Chi PuiChen Li Jia - Allergic rhinitis (AR) affects 10-25% of the global population, with nasal epithelial cell (NEC) dysfunction acting as a central driver of its pathogenesis. Allergen-specific immunotherapy (AIT) is the sole disease-modifying treatment for AR; however, its optimization is hindered by the lack of validated predictive biomarkers. N6-methyladenosine (m6A) is a pivotal epitranscriptomic regulator of immune and epithelial homeostasis. This study aims to delineate the m6A modification landscape in NECs during AIT to identify candidate genes associated with clinical efficacy and elucidate the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/04/19
Lai ShiminYu LeiSun LinZheng HongyuanLu TongLi ZhengqiChen ChanghuiWei YiWen Weiping - Periodontitis is a chronic infectious disease characterized by the destruction of the tooth-supporting tissues, including the gingiva, periodontal ligament, and alveolar bone, which may ultimately lead to tooth loss. However, blood-based biomarkers reflecting systemic inflammation in periodontitis remain poorly defined. We analyzed plasma proteomic data from the UK Biobank using Olink Explore proteomics to identify systemic protein signatures distinguishing chronic periodontitis patients ( = 90) from healthy controls ( = 2234). Among 2151 proteins passing quality control, 29 proteins showed significant differential expression (FDR < 1.0 × 10). Growth differentiation factor 15 (GDF15) exhibited the strongest upregulation (mean NPX: -0.183 to 0.157, effect size = 0.337, FDR = 2.82 × 10), followed by N-terminal pro-B-type natriuretic peptide (NT-proBNP) (effect size = 0.594), Interleukin-6 (IL-6) (effect size = 0.450), and Insulin-like growth factor binding protein-(4IGFBP4) (effect size = 0.269). Multiple TNF receptor superfamily members (TNFRSF1A/1B, TNFRSF10A/10B) and proteins involved in extracellular matrix remodeling (COL6A3, ADAM12) and vascular stress (ADM) were significantly elevated. In contrast, EGFR and DNER showed decreased expression. Protein-protein interaction network analysis revealed IL-6 as a central hub protein forming a tightly interconnected cluster with TNF receptor family members. These findings indicate systemic plasma protein profiles associated with chronic periodontitis within this population-based cohort. The identified proteins may provide a basis for future evaluation of blood-based biomarkers for chronic periodontitis, pending further validation. - Source: PubMed
Publication date: 2026/03/09
Kim Su KangKim Min KyoungKang Sang WookBan Ju Yeon - Redox signaling governs bone remodeling, but whether systemic redox balance is associated with incident osteoporosis, genetic susceptibility, and proteomic/inflammatory pathways at population scale remains unclear. - Source: PubMed
Publication date: 2026/01/20
Zhu YuanpengLiu DiYin XiangjieZhang Terry JianguoWu Nan