Ask about this productRelated genes to: ZBTB38 antibody
- Gene:
- ZBTB38 NIH gene
- Name:
- zinc finger and BTB domain containing 38
- Previous symbol:
- -
- Synonyms:
- FLJ35036, CIBZ, ZNF921, PPP1R171
- Chromosome:
- 3q23
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-12
- Date modifiied:
- 2015-08-26
Related products to: ZBTB38 antibody
Related articles to: ZBTB38 antibody
- Circular RNAs (circRNAs) hold significant potential both in the regulation of tumor progression and in clinical applications for tumors. This study aims to investigate the functional mechanism of circ-ZBTB38 in melanoma progression as well as its potential clinical application value. - Source: PubMed
Publication date: 2026/03/28
Zhang WanqiYang NanWang YuekaiLi XinyingTan LiuchangLi HongliLu Yuangang - Persistently infected (PI) calves resulting from maternal Bovine viral diarrhea virus (BVDV) infection during early gestation are the main source of viral transmission and pose a serious threat to the sustainable production of herds. PI cattle appear clinically normal, elucidating the molecular-level alterations is critical for understanding their specific characteristics. Moreover, the identification of candidate biomarkers for diagnosing PI cattle will provide valuable insights to support effective strategies for the control and eventual eradication of BVDV. At the same time, few studies have focused on the mothers of PI calves (Trojan dam). - Source: PubMed
Publication date: 2026/03/10
Wang JiahaoChen SiqianLai WanyiFeng XiaoZhao QingyaoMi SiyuanXu ChuangQin TongCao JieYu Ying - The X-linked inhibitor of apoptosis protein (XIAP) is a key suppressor of apoptosis, crucial for cellular differentiation, embryogenesis, and cancer progression. However, its upstream regulatory mechanisms remain poorly understood. Here, we demonstrate that the zinc finger transcription factor Zbtb38, a negative regulator of apoptosis, modulates XIAP expression in both loss- and gain-of-function experiments, irrespective of p53 expression. Notably, XIAP overexpression rescues the apoptosis induced by Zbtb38 knockdown, indicating that Zbtb38-associated apoptosis is at least partially XIAP-dependent. Mechanistically, Zbtb38 binds to E-box motifs within upstream regulatory regions of XIAP and activates its transcription. During embryonic stem cell differentiation and embryogenesis, Zbtb38 depletion increases apoptosis and reduces XIAP and Bcl-2 expression, underscoring their functional relevance in these processes. Analysis of human tumor datasets reveals a strong positive correlation between ZBTB38 and XIAP expression, with elevated ZBTB38 levels associated with high-grade malignancies. Furthermore, Zbtb38 knockdown induces apoptosis in cancer cells with reduced XIAP expression, regardless of p53 expression. Collectively, these findings uncover a novel Zbtb38-XIAP axis that regulates apoptosis during cellular differentiation, development, and oncogenesis and highlight its therapeutic potential in XIAP-driven and p53-deficient tumors. - Source: PubMed
Publication date: 2026/03/17
Shigeoka ToshiakiNagaoka HiroyukiNurulita Nunuk AriesTada ShogoBessho YasumasaIshida YasumasaMatsuda Eishou - Congenital diaphragmatic hernia (CDH) is a developmental anomaly associated with high mortality and morbidity, primarily attributed to accompanying pulmonary hypoplasia. Genetic factors are crucial in the etiology and pathogenesis of CDH, with various copy number variations (CNVs) and gene sequence variants implicated in this malformation. Previous studies have underscored the importance of retinoic acid (RA) signaling pathways and related genes. Nonetheless, the complexity of diaphragmatic development involving cell migration, cytoskeleton organization, and myogenesis suggests that candidate CDH genes extend beyond the RA pathway. To explore novel candidate gene variants and their roles in CDH, we performed whole exome sequencing (WES) in CDH-affected fetuses. - Source: PubMed
Somayyeh Heidargholizadeh GTurgut Gozde TutkuAltunoglu UmutSivrikoz Tugba SaracUyguner Zehra OyaBasaran SeherKaraman BirsenGulec Cagri - The black Tibetan sheep is an important local livestock breed. Deciphering the genetic and molecular mechanisms governing their growth and development is crucial for breeding programs. However, research on their serum metabolome and population genetic structure remains limited. - Source: PubMed
Publication date: 2025/12/24
Gan JiachengJi QiurongGao WeiZhang YuZhang XianhuaSa RengeerliHou ShengzhenGui Linsheng