Ask about this productRelated genes to: CITED4 antibody
- Gene:
- CITED4 NIH gene
- Name:
- Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-29
- Date modifiied:
- 2016-10-05
Related products to: CITED4 antibody
Related articles to: CITED4 antibody
- Cardiac hypertrophy, characterized by an increase in the size of cardiac myocytes, is an adaptive response to increased workload on the cardiac tissue following physiological stimuli, such as exercise, and pathological conditions, such as hypertension or valvular heart disease. Typically, physiological hypertrophy induced by various exercise modalities leads to beneficial adaptations, such as improved contractile function and increased oxidative capacity. Understanding the molecular mechanisms underlying physiological cardiac hypertrophy is crucial for developing targeted therapeutic strategies. This review provides a comprehensive overview of current knowledge of physiological cardiac hypertrophy, with a particular focus on adaptations induced by various exercise modalities. We delved into the potential cellular and molecular pathways involved in physiological hypertrophy including IGF1/PI3K/AKT, angiotensin2, hepatocyte growth factor, platelet-derived growth factor. MAPK/ERK cascade, calcineurin, Neurogelin2 and downstream transcriptional factors such as HAND2, GATA4, MEF2, NKX2.5, TBX5, NFAT, c/EBPβ, CITED4, PHLPP, as well as the role of microRNAs (miRNAs) like miR-222 and miR-17 in mediating these adaptations. Furthermore, we used comparative tables to illustrate the differential effects of endurance, high-intensity interval training (HIIT), and resistance training on structural, molecular, and functional cardiac parameters, as markers of physiological hypertrophy. We also presented pathway-specific percentage changes observed across different exercise training modalities to highlight key differences. The discussion integrated these findings to explore translational perspectives and to offer the most beneficial exercise training schedules that induce physiological hypertrophy. - Source: PubMed
Publication date: 2026/03/31
Gharaat Mohammad AliSheykhlouvand MohsenChoobdari Hamid RezaSuzuki KatsuhikoArazi Hamid - EphrinB2 and its receptor EphB4 have been reported to play a crucial role in the development of the cardiovascular system, and the process of coronary artery disease (CAD) is closely related to angiogenesis. The aim of this study is to identify and analyze the therapeutic value of the EphrinB2/EphB4 signaling pathway and angiogenesis-related biomarkers. - Source: PubMed
Publication date: 2026/07/20
Liu ChunyuCheng WeiweiWei XingSong DiZhang Zhibiao - Cardiac plasticity declines with age; however, mechanisms underlying aerobic training (AT)-induced cardiac remodeling across developmental stages remain unclear. Exercise-induced hypertrophy is mediated by PI3K/Akt/mTOR signaling and its downstream effector CITED4, but whether these pathways respond uniformly across age is unknown. This study investigated age-dependent effects of AT on the Akt1/mTOR/CITED4 axis in rat myocardium. - Source: PubMed
Publication date: 2026/06/29
Haji Asiabani PouriaGhasemnian Agha AliKarimi Asl AkramWong Alexei - Recent advances in predicting and modeling conformational ensembles of intrinsically disordered proteins (IDPs) have provided much needed insights into sequence-ensemble relationships. It is thought that conservation of physicochemical properties, but not the exact identity or order of the amino acids, maintains IDP ensemble properties that are crucial for function. However, detailed experimental studies are still required to fully understand the relationships between sequence and function in IDPs. The human CITED proteins, which are fully disordered transcriptional regulators, share conserved C-terminal transactivation domains (CTADs) that interact with the TAZ1 domain of the transcriptional coactivators CBP/p300. The conserved CTADs harbor amino acid substitutions in regions that are known to be important for interactions of CITED2 with TAZ1, but the effects of these substitutions on TAZ1 binding for the other CITED proteins are unknown. Here, we use solution NMR spectroscopy, circular dichroism, and surface plasmon resonance to characterize the conformational ensembles, dynamics, and interactions of the CITED CTADs. The CTADs are disordered in isolation, although the CITED2 CTAD uniquely displays residual helical structure that is sensitive to ionic strength and protein concentration. In contrast, the CITED1 and CITED4 CTADs remain largely disordered and exhibit more uniform dynamics. Quantitative binding measurements reveal differences in thermodynamics and kinetics for the CTADs' interactions with TAZ1, with CITED2 binding most tightly and CITED4 exhibiting significantly weaker affinity. Our results highlight the sensitivity of IDP conformational ensembles to minor sequence changes and the impacts that changes in IDP structures and dynamics can have on biological functions. - Source: PubMed
Do To UyenKraft Emma JChappell Garrett FParnham StuartBerlow Rebecca B - Tail docking, serving as an important management intervention in animal husbandry, plays a significant role in regulating tail fat deposition and improving production performance and health status in fat-tailed sheep. This study systematically revealed the reprogramming effects of tail docking on the epigenetic landscape and transcriptome of fat-tailed sheep by integrating whole-genome bisulfite sequencing (WGBS) and RNA m6A methylated immunoprecipitation sequencing (MeRIP-seq). At the DNA level, the tail-docked group exhibited a pronounced trend of hypomethylation across multiple functional genomic regions, including promoters, exons, and introns. Differentially methylated regions (DMRs) were significantly enriched in pathways related to tissue development and stress response, such as the Hippo signaling pathway and adherens junctions. Pyrosequencing validation of the promoter region of the key gene DGAT1 further confirmed the reliability of the WGBS data. At the RNA level, RNA m6A modifications showed an overall up-regulated pattern: the tail-docked group displayed higher numbers of m6A peaks, greater total peak length, and increased genomic coverage compared to the control group, along with better overall prediction of modification sites. Genes associated with differential m6A peaks were closely related to processes such as stem cell pluripotency and cytoskeleton regulation. qPCR validation of several methylation-related enzyme genes (e.g., METTL3, FTO, YTHDF1) yielded results consistent with the sequencing trends. Through integrated analysis of DNA methylation and RNA methylation, we identified 143 genes with concurrent changes in methylation and mRNA expression, among which 41 genes were regulated by both DNA and RNA methylation. These genes were primarily enriched in the adherens junction pathway. Notably, two core genes CITED4 and ZNF644 showed significant changes across all three levels: DNA methylation, RNA methylation, and mRNA expression. This study systematically elucidates the epigenetic mechanism by which tail docking stress induces coordinated DNA hypo-methylation and RNA m6A hyper-methylation to regulate transcriptomic reprogramming in response to environmental intervention. The findings provide novel insights into the molecular basis of trait formation in livestock. - Source: PubMed
Publication date: 2026/02/04
Zhang JianMa YannanSong Shuzhen