Ask about this productRelated genes to: SOCS1 antibody
- Gene:
- SOCS1 NIH gene
- Name:
- suppressor of cytokine signaling 1
- Previous symbol:
- -
- Synonyms:
- SOCS-1, SSI-1, JAB, TIP3, Cish1
- Chromosome:
- 16p13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2015-08-26
Related products to: SOCS1 antibody
Related articles to: SOCS1 antibody
- Tumor-associated macrophages (TAMs) can suppress antitumor immunity and reduce responses to immune checkpoint blockade (ICB). Here, we asked how TAM programs contribute to ICB non-response. Integration of public single-cell RNA sequencing (scRNA-seq) datasets across 12 cancer types identified SPP1 TAMs as a tumor-enriched macrophage subset with immunosuppressive features. TAMs from ICB non-responders across multiple tumor types exhibited higher SPP1 expression. In murine models, macrophage Spp1 deletion suppressed tumor growth and prolonged survival and was associated with a remodeled tumor microenvironment featuring reduced T regulatory cell (Treg) frequencies, increased interferon (IFN)-γ CD4 and GZMB CD8 T cells, and augmented interferon-stimulated gene (ISG) expression across immune and malignant compartments. Mechanistically, intracellular SPP1 interacted with TRIM21 to limit SOCS1 ubiquitination, stabilizing SOCS1-mediated negative feedback and dampening IFN-γ-STAT1-ISG signaling in TAMs. Consistently, SPP1 targeting enhanced the efficacy of anti-PD-L1 therapy in vivo. Thus, remodeling the TME via targeting the TAM SPP1-IFN-γ axis presents a therapeutic avenue for enhancing responses to ICB. - Source: PubMed
Publication date: 2026/04/27
Sun LiangzhanChu XiaojingKong TingtingChen XiruiRu JianingGao QianqianZhou WeiWang XiliangCheng SijinZhu LinnanZhang Zemin - Aberrant activation of the Janus kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway is associated with various pathological conditions. Suppressor of Cytokine Signaling (SOCS) proteins are able to inhibit this pathway by competitively binding to the STAT binding sites on JAK kinases (blocking the binding of STATs to JAK kinases). However, the mechanism of selective inhibition of JAK kinases by SOCSs remains poorly understood. Here, we performed microsecond-scale molecular dynamics (MD) simulations combined with molecular mechanics/generalized born surface area (MM/GBSA) binding free energy calculations, covariance analysis, and principal component analysis (PCA) to systematically compare the binding characteristics of six distinct JAK/SOCS complexes. The MM/GBSA results showed that the binding affinity of SOCS1/SOCS3 to JAK1/TYK2 is significantly stronger than that of SOCS2 to JAK1/TYK2. Correspondingly, PCA and covariance analysis revealed that SOCS2 and JAK1/TYK2 moved toward the opposite directions during the simulation. All these indicate that SOCS1/SOCS3 binds more stably to JAK1/TYK2 than SOCS2, implying that SOCS1/SOCS3 has a better inhibitory effect on JAK1/TYK2. Furthermore, the results of energy decomposition residues and hydrogen bond analysis illustrated that the strong binding ability of SOCS1/SOCS3 to JAK1/TYK2 is based on the presence of "Y", "QR", and "FF" motifs (missing in the SOCS2) in its KIR region and BC loop, which are able to form stable hydrogen bond networks and Met-aromatic interactions with the GQM motifs of JAK1/TYK2. This might be the fundamental reason why SOCS1/SOCS3 has a significantly stronger selective inhibitory effect on JAK1/TYK2 than SOCS2. Our work elucidates the dynamic structural basis of JAK/SOCS binding selectivity at the atomic level, providing new insights into the mechanism of JAK kinase selectivity and laying the foundation for the development of structure-based JAK1/TYK2-targeted cancer therapy drugs. - Source: PubMed
Publication date: 2026/04/27
Zhai XinmiaoLi YanYang Yong-BiaoLiu YeChu Huiying - - Source: PubMed
Publication date: 2026/04/27
Zhang KaijunZou XinMa ZhiyiWang WeihongWu YongmingLin ZhaoshengLuo MachangLiang RongzhangWu Xiaoming - - Source: PubMed
Publication date: 2026/04/25
Salmani MahyarRastegari-Pouyani MohsenAfshar SaeidTalebi-Ghane ElahehEftekharian Mohammad Mahdi - The journal retracts the article titled, "Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs" [...]. - Source: PubMed
Publication date: 2026/04/16
Li XiaochuanTian FengWang Fei