Ask about this productRelated genes to: CLASP1 antibody
- Gene:
- CLASP1 NIH gene
- Name:
- cytoplasmic linker associated protein 1
- Previous symbol:
- -
- Synonyms:
- KIAA0622, MAST1
- Chromosome:
- 2q14.2-q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-12
- Date modifiied:
- 2019-04-18
Related products to: CLASP1 antibody
Related articles to: CLASP1 antibody
- Increased levels of α-tubulin and its post-translational modifications (PTMs) are found in human heart failure and could initiate diastolic dysfunction by modulating cardiomyocyte stiffness. How these modifications occur and how they may underlie cardiac dysfunction remains unknown. Upstream kinases may play a critical role, but this has not been explored. - Source: PubMed
Publication date: 2026/02/20
Algül SılaDuursma InezHesson JenniferMathieu Juliede Goeij-de Haas RichardHenneman Alex APiersma Sander RPham Thang VSchoonvelde Stephan A CMichels MichelleSoleilhac Jean-MarcMoutin Marie-JoJimenez Connie RRegnier MichaelKuster Diederik W Dvan der Velden Jolanda - Convergent evolution offers a unique lens through which to explore the molecular underpinnings of significant phenotypic transformations. Similar selective pressures likely drove the evolution of analogous milk traits in sheep and goats. Consequently, the current study aimed to identify common selection signals for milk traits across dairy and non-dairy breeds of sheep and goats worldwide. - Source: PubMed
Publication date: 2026/02/06
Akhatayeva ZhanerkeShi YilongDossybayev KairatMalmakov NurlanCheng HairongBaatar NarantuyaYang JiLi MenghuaLin KejianXu Songsong - A major goal of biomedical research is to assign functions to the myriad alternative RNA and protein isoforms. This challenge is particularly relevant to the mammalian nervous system, which produces complex repertoires of alternative splicing events. Here, we describe CHyMErA-seq, a platform that couples systematic deletion of exons to a single cell transcriptomics read-out, and apply this method to investigate a critical program of brain-specific microexons. Perturbation of microexons during neurogenesis reveals convergent roles in the temporal regulation of gene expression programs that direct signaling pathways and morphogenesis. We further observe microexons, including those in the Bin1, Clasp1, Gfra1, Med23, Ptprf and Ralgapb genes, that are required for the correct timing of autism-linked gene expression. Collectively, we describe a flexible system for isoform-resolution perturbation at a single cell level, together with insights into the roles of microexons in the developmental timing of neurogenesis transcriptomic signatures linked to brain disorders. - Source: PubMed
Publication date: 2026/02/03
Dupas Steven JParada Guillermo ELi Jack DaiyangBrown Kevin RMoffat JasonBlencowe Benjamin J - Natural killer (NK) cells are the first line of defense against viral infections and tumors. Their cytotoxic activity relies on the formation of an immune synapse (IS) with target cells. The lymphocyte function-associated antigen (LFA)-1 plays a central role in NK cell cytotoxicity by modulating NK-IS assembly and maturation. LFA-1 organization at the IS involves a Golgi-dependent mechanism that has not been fully elucidated. CLIP-associating proteins (CLASP) 1/2 are microtubule plus-tip interacting proteins that control the dynamics of Golgi-derived microtubules (GDMTs). In the present study, we found that CLASP1/2 depletion impaired LFA-1 organization at the IS and inhibited the polarization of the centrosome and the lytic granules toward the target cell, thereby compromising NK cytotoxic function. Our results also revealed the role of the Golgi apparatus as a microtubule-organizing center (MTOC) in these cells. Furthermore, we found that, similar to what was described in other cell types, NK cells require CLASP1/2 and AKAP350 for efficient nucleation of microtubules at the Golgi. Overall, this study uncovers the role of CLASP1/2 in the maturation of the lytic IS in NK cells and presents evidence supporting the contribution of GDMTs in this process. - Source: PubMed
Pariani Alejandro PHuhn VictoriaRivabella Maknis TomásAlonso VictoriaAlmada EvangelinaZecchinati FelipeVena RodrigoOjeda MaraFavre CristiánGoldenring James RKaverina IrinaLarocca M Cecilia - Breast cancer (BC) is the most prevalent malignancy among women worldwide. Growing evidence highlights the crucial role of circular RNAs (circRNAs) in BC carcinogenesis; however, their underlying mechanisms remain largely unknown. In this study, we identify circCLASP1, which is significantly upregulated in BC tissues (n = 65) and serum samples (n = 61). Its expression correlates with lymph node metastasis, ki67 expression, and tumor size. Receiver operation characteristic (ROC) curve analysis reveals area under the curve (AUC) values of 0.8196 (BC tissues) and 0.8902 (BC serum), respectively. Functionally, circCLASP1 knockdown significantly suppresses BC cell proliferation, migration, and invasion. Mechanistically, circCLASP1 prevents the ubiquitin-mediated degradation of GLI1 protein by facilitating its interaction with CCT2, thereby stabilizing GLI1. Moreover, circCLASP1 enhances the nuclear accumulation of GLI1, leading to increased SNAIL expression and thereby upregulating the expression of CCL2 and CCL5, which in turn promotes macrophage M2 polarization, ultimately resulting in BC progression and subsequent lung metastasis. Further analysis reveals that U2AF2 regulates circCLASP1 biogenesis. Collectively, these findings demonstrate that circCLASP1 promotes BC progression and an immunosuppressive microenvironment via the CCT2/GLI1/SNAIL axis, highlighting its potential as a prognostic biomarker and therapeutic target for BC. - Source: PubMed
Publication date: 2025/11/17
Zhou LijunLiu MeiLiu FujunWang ZhengkunLi XinyuPeng XiaoyuMa WenqiangGuo PeilanYuan LifangWolczynski SlawomirRahman Nafis AhmedSong WeiLi Xiangdong