Ask about this productRelated genes to: CD89 antibody
- Gene:
- FCAR NIH gene
- Name:
- Fc fragment of IgA receptor
- Previous symbol:
- -
- Synonyms:
- CD89
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-06
- Date modifiied:
- 2015-04-24
Related products to: CD89 antibody
Related articles to: CD89 antibody
- Lung cancer (LC), particularly lung adenocarcinoma, is a leading cause of cancer-related mortality, while systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a chronic fibrotic autoimmune disorder. Growing evidence suggests shared molecular mechanisms between these conditions, although their genetic overlap remains insufficiently characterized. In this study, integrative bioinformatics approaches were applied to identify common differentially expressed genes (DEGs) and regulatory networks linking LC and SSc-ILD. Comparative transcriptomic analysis revealed 72 shared DEGs, including 10 hub genes: , , and (upregulated), and , , , , , , and (downregulated). Regulatory network analysis identified key miRNAs (hsa-miR-34a-5p, hsa-miR-126-3p, hsa-miR-335-5p) and central transcription factors (FOS, JUN, NFKB1). Pathway enrichment highlighted interleukin-10 signaling as a critical shared pathway, implicating immune regulation and extracellular matrix remodeling. Molecular docking suggested a potential interaction between doxycycline and MMP7 (binding affinity -6.4 kcal/mol), while X-ray diffraction and Rietveld refinement confirmed its crystalline purity. Additionally, doxycycline demonstrated antibacterial activity against via minimum inhibitory concentration assays. Overall, these findings provide preliminary insights into shared molecular features between LC and SSc-ILD and suggest doxycycline as a potential repurposed candidate warranting further experimental and clinical validation. - Source: PubMed
Publication date: 2026/05/27
Dasgupta SanjuktaGhosh MoupiyaSadhukhan SukhenduSet Srijit - Delirium, acute confusion marked by fluctuations of attention and concentration, is associated with increased risk for poor long-term health outcomes, including Alzheimer's disease (AD), institutionalization, and mortality. Cardio-autonomic control is implicated in modulating response to acute stressors, and alteration is separately shown to predict mortality. Heart rate (HR) fluctuations display fractal correlations (similar temporal autocorrelation across different time scales) that reflect a dynamic interplay between sympathetic and vagal outflows, where disruption is thought to contribute to neuronal damage. We hypothesized that fractal cardiac activity regulation FCAR (α₁) correlations in HR predicts incident delirium. - Source: PubMed
Publication date: 2026/04/19
Gaba ArlenLi PengCai RuixueChhajed MansiHu KunGao Lei - The comorbid state of obstructive sleep apnea (OSA) and coronary artery disease (CAD) has emerged as a significant public health challenge. However, the underlying metabolic regulation and molecular biomarkers linking to the CAD and OSA comorbidity (CADOSA) remain poorly understood. This study aimed to identify non-invasive biomarkers for the CADOSA comorbidity. - Source: PubMed
Publication date: 2026/03/10
Chen ShuhanLiu QingquanLiu JingZheng HuijuanLi WanqiYu Liying - Limited battery capacity poses a challenge for autonomous robots. We believe that instead of relying solely on electric motors and batteries, basically Conventional Autonomous Robots (CAR), one way to address this challenge may be to develop Biohybrid Autonomous Robots (BAR), based on current achievements of the field of biohybrid robotics. The BAR approach is based on the facts that fat store high amount of energy, that biological muscles generate decent force per unit of cross-sectional area and that biological muscles have capability for regeneration and adaptation compared to electric motors. To reach conclusions about the feasibility of BAR, this study uses data from the fields of muscle energetics, robotics, engineering, physiology, biomechanics and others to perform analysis and interdisciplinary calculations. Our calculations show that the BAR approach is up to 5.1 times more efficient in terms of the mass of energy substrate to useful energy transported than the Conventional Autonomous Robots (CAR) with mass-produced batteries in an ideal scenario. The study also presents the model for determining the point of the rational use of the BAR, taking into the account basal metabolism of living systems. The results of this study provide a preliminary basis for further research of the BAR, putting it into the context of the other possible solutions for energy autonomy problem: Generator-Powered Autonomous Robots (GPAR) and Fuell-Cell Autonomous Robots (FCAR). - Source: PubMed
Publication date: 2025/10/28
Kuplinov Georgiy N - This study aimed to investigate the diagnostic potential of neutrophil extracellular traps (NETs)-related genes in acute ischemic stroke (AIS) through comprehensive bioinformatics analysis. - Source: PubMed
Publication date: 2025/08/29
Zhang HaipengWu TiLi XinghuaLiu ShuangqingWang YuanyuanCao Yang