Ask about this productRelated genes to: p0071 antibody
- Gene:
- PKP4 NIH gene
- Name:
- plakophilin 4
- Previous symbol:
- -
- Synonyms:
- p0071
- Chromosome:
- 2q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-14
- Date modifiied:
- 2014-11-19
Related products to: p0071 antibody
Related articles to: p0071 antibody
- This study aimed to investigate whether plakophilin 4 (PKP4) mediates the effects of hydrogen sulfide (HS) in promoting diabetic wound healing. - Source: PubMed
Publication date: 2026/04/15
Zhang BishanLi PingJiang NanxingXue WenlongZhu YichunWang Mingjie - - Source: PubMed
Publication date: 2026/03/05
Zhou FangLi JinghuiLu Minjie - Classical cadherins are instrumental for connecting cells into tissues by forming adherens junctions (AJs), a structurally diverse class of cell-cell adhesions tailored to specific membrane domains, cell types, and particular functions. The mechanisms that underlie the AJ diversification remain unknown. Here, we show that two δ-catenin family members, p120 and plakophilin 4 (pkp4), which bind the intracellular region of classical cadherins, promote distinct modes of cadherin clustering, thereby contributing to AJ specialization. The mode promoted by p120 is driven by interactions between cadherin-associated protein, α-catenin, and actin filaments. This "canonical" clustering mechanism generates apical and basal AJs that play a major role in overall cell-cell adhesion. The mode promoted by pkp4 is driven by an α-catenin-independent mechanism. It generates lateral AJs, which apparently function in processes other than cell-cell adhesion. Collectively, our findings show that δ-catenins regulate the balance between different AJ assembly pathways, thereby contributing to AJ diversification. - Source: PubMed
Publication date: 2026/02/26
Indra IndrajyotiTroyanovsky Regina BKorobova Farida VTroyanovsky Sergey M - The uterus is a pivotal organ for mammalian reproduction, directly determining reproductive success by orchestrating embryo implantation, placental development, fetal nourishment, and parturition. However, the molecular mechanisms regulating high fecundity in the uterus across different stages of the estrous cycle remain unclear. This study aimed to elucidate the genetic regulation of goat fecundity through integrated proteomic and transcriptomic analyses of uterine tissues. - Source: PubMed
Publication date: 2026/02/21
Zou DongbinDu XiaolongLiu YufangFang MeiyingChu Mingxing - Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammatory and immune system diseases. This study aimed to identify LN biomarkers and mechanisms via systems biology approach, and multi-omics integration, and to screen potential active ingredients of QS for the treatment of LN. First, bioinformatics and machine learning were used to screen five genes, namely CHI3L1, CX3CR1, GBP2, CCND1, and , as well as the NF-kappaB signaling pathway. An external dataset was then employed to confirm that GBP2 plays a crucial role in the pathogenesis of LN. Immune infiltration analysis revealed significant changes in the proportion of CD4 T cells. Subsequently, an LN mouse model was established to evaluate QS's therapeutic effects. Results showed that QS treatment significantly improved symptoms and alleviated renal damage in these mice. Metabolomics and Western blot analyses further demonstrated that abnormal elevations of proteins related to purine metabolism and the NF-kappaB pathway were closely associated with LN's pathogenesis. Finally, molecular docking and MMGBSA binding energy calculations identified cichoriin as a key component. Molecular dynamics simulations further predicted a strong binding affinity between cichoriin and GBP2, along with favorable ADMET properties. In summary, GBP2 is a key druggable gene in LN. This study verifies QS's efficacy and positions cichoriin as a novel immunomodulator acting on the GBP2/NF-kappaB axis. - Source: PubMed
Publication date: 2025/11/06
Zhu KaojiangQian RuiHuang ZhuangHong XingJiang QiXiao BenjiangChen MengWen YuxinLi ShihaoChen PengyuHuang PingWang QiongHuang FangLi JingjingHan Lintao