Ask about this productRelated genes to: DSG4 antibody
- Gene:
- DSG4 NIH gene
- Name:
- desmoglein 4
- Previous symbol:
- -
- Synonyms:
- CDHF13, LAH
- Chromosome:
- 18q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-04
- Date modifiied:
- 2015-09-11
Related products to: DSG4 antibody
Related articles to: DSG4 antibody
- Psoriasis is a non-communicable inflammatory skin disease that affects approximately 2%-3% of the world's population. Given its high impact on quality of life and the fact that a subset of patients exhibits suboptimal or secondary loss of response to current treatments, identifying new therapeutic strategies is crucial. Proliferation-associated protein 2G4 (PA2G4) is a transcription factor that has been exclusively studied in cancer research, where it promotes cell growth and enhances tumourigenesis by inhibiting apoptosis. However, its role in inflammatory skin diseases remains largely unknown. - Source: PubMed
Publication date: 2026/04/20
Raunegger TheresaWasserer SophiaEigemann JessicaHillig ChristinaAydin GörkemKurzen NilsSchmidt-Weber Carsten BMenden Michael PGarzorz-Stark NatalieWeßels IngaEyerich StefanieEyerich KilianBiedermann TiloLauffer FelixJargosch Manja - Cavitary pulmonary tuberculosis (cPTB) is the most destructive manifestation of infection and is associated with poor treatment response and high transmissibility. To capture the systemic disturbances that accompany cavity formation, we profiled sera from 30 cPTB patients, 30 noncavitary PTB patients, and 30 matched healthy volunteers using proximity-extension proteomics and untargeted ultraperformance liquid-chromatography tandem mass spectrometry. Multigroup analysis revealed broad suppression of cell-junction proteins and rewiring of amino-acid and lipid metabolism in PTB; these changes were accentuated in cPTB, where 15 cardiomyocyte-associated proteins and fifty-nine metabolites differed significantly from noncavitary PTB. Integrated network mapping converged on two consistently down-regulated molecules─desmoglein-4 (DSG4) and amyl salicylate─whose combined abundance showed moderate discrimination of cPTB from noncavitary PTB (AUC = 0.738). These findings are consistent with cavity formation being associated with perturbations in cardiovascular-related pathways and broad metabolic reprogramming, and they nominate the DSG4-amyl salicylate pair as an exploratory, hypothesis-generating signature that requires validation in independent cohorts before any clinical interpretation or host-directed therapeutic use. - Source: PubMed
Publication date: 2025/12/09
Wang JianhaiZhang DongDu ChunnanSun HaibaiLiu ChunfengLi YumingCairang ZhoumaoLi RuZhuoma GazangMa JunRen QingcuoSun XinChen Huaiyong - Alopecia areata (AA) is a chronic autoimmune disorder characterized by non-scarring hair loss, with subtypes ranging from patchy alopecia (AAP) to alopecia totalis and universalis (AT/AU). The aim of this research is to investigate molecular features across AA severity by performing an integrated analysis of scalp transcriptomic datasets (GSE148346, GSE68801, GSE45512, GSE111061) and matched serum proteomic data from GSE148346. Differential expression analysis indicated that, relative to normal scalp, non-lesional AA tissue shows early immune activation-including Type 1 ( (), , (), ()) and Type 2 () signatures-together with reduced expression of hair-follicle structural genes (, ()) (FDR < 0.05, |fold change| > 1.5). Lesional AAP and AT/AU scalp showed stronger pro-inflammatory upregulation and greater loss of keratins and keratin-associated proteins (, desmoglein 4 (), ) compared with non-lesional scalp (FDR < 0.05, |fold change| > 1.5). Ferroptosis-associated genes ( (), (), (lipocalin 2) , ) and IRS (inner root sheath) differentiation genes (, trichohyalin ()) were consistently repressed across subtypes, with the strongest reductions in AT/AU lesions versus AAP lesions, suggesting that oxidative-stress pathways and follicular structural integrity may contribute to subtype-specific pathology. Pathway analysis of lesional versus non-lesional scalp highlighted enrichment of IFN-α/γ, cytotoxic, and IL-15 signaling. Serum proteomic profiling, contrasting AA vs. healthy controls, corroborated scalp findings, revealing parallel alterations in immune-related proteins (CXCL9-CXCL10, CD163, interleukin-16 (IL16)) and structural markers (angiopoietin 1 (ANGPT1), decorin (DCN), chitinase-3-like protein 1 (CHI3L1)) across AA subtypes. Together, these data offer an integrated view of immune, oxidative, and structural changes in AA and found ferroptosis-related and IRS genes, along with immune signatures, as potential molecular indicators to support future studies on disease subtypes and therapeutic strategies. - Source: PubMed
Publication date: 2025/10/03
Xi LiPeeva ElenaYamaguchi YujiYe ZhanHyde Craig LGuttman-Yassky Emma - Alopecia areata (AA) is an immune-mediated inflammatory skin disease that targets hair follicles. Current research yields varied lists of differentially expressed genes (DEGs). A meta-analytic approach is essential to consolidate these findings into a consistent tissue signature. This study aimed to perform a meta-analysis of gene expression datasets to establish a comprehensive molecular signature of AA lesional scalp. - Source: PubMed
Publication date: 2025/08/01
Rivera-Ruiz IreneGay-Mimbrera JesúsGómez-Arias Pedro JAguilar-Luque MacarenaJuan-Cencerrado MiguelMochón-Jiménez CarmenParra-Peralbo EsmeraldaIsla-Tejera BeatrizGómez-García FranciscoRuano Juan - Shaanbei white cashmere goat is an excellent cashmere goat breed, and its market favored cashmere from the secondary hair follicles. Hair follicles mature around birth and each hair follicle repeatedly undergoes a growth cycle that comprises three distinct stages: anagen, catagen and telogen. Understanding the molecular mechanisms controlling cyclic hair follicle changes is essential for optimizing hair follicle function and improving cashmere production. - Source: PubMed
Publication date: 2025/05/19
Du JiamianSui MenghuaSong ZhihaoLiang ShuangshuangZheng YujieWang Xin