Ask about this productRelated genes to: TIP47 antibody
- Gene:
- PLIN3 NIH gene
- Name:
- perilipin 3
- Previous symbol:
- M6PRBP1
- Synonyms:
- TIP47, PP17
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-16
- Date modifiied:
- 2014-11-19
Related products to: TIP47 antibody
Related articles to: TIP47 antibody
- - Source: PubMed
Publication date: 2026/04/07
Tian KangMa GuoyuanGuo DeyuJiang HuiZhao XinjieWang GuanghuiDu JiajunPang Zhaofei - Viruses hijack host metabolic resources for replication. Previous studies have shown that classical swine fever virus (CSFV) infection induces host lipid metabolic reprogramming.However, research into the exact regulatory mechanisms between CSFV and lipid metabolism remains limited. Lipophagy refers to the degradation of lipid droplet contents to release free fatty acids(FFAs), CSFV induces autophagy to promote its replication, the regulatory mechanism between CSFV and lipophagy is unclear. In this study, we found that lipid droplets(LDs) initially accumulate and then decrease following CSFV infection. Autophagy activity was negatively correlated with lipid drople levels. Subsequent experiments revealed that CSFV induces lipophagy in Hepatic stellate cells(HSCs)and upregulates perilipin3(PLIN3) expression, a LD-associated protein that facilitates viral replication. Further studies demonstrated that PLIN3 activates the AMPK signaling pathway to promote lipophagy-mediated FFAs release. This FFA increase could be blocked by autophagy inhibitors. Notably, exogenous FFA addition reversed the shPLIN3-induced impairment of CSFV replication. Overall, this finding provides new insights into the mechanisms of virus-host lipid metabolism interactions. - Source: PubMed
Publication date: 2026/02/25
Li BingkeZou LinkeSun ChenchenJiang JiananLi ShurouWang JiaxinHe YintaoQin YuweiZeng SenSong YiwanZeng WeijunYi LinFan ShuangqiChen JindingWu Keke - To investigate the fillet quality traits (texture, flavor, nutritional value) formation and the mechanism of muscular lipid deposition in triploid rainbow trout, low (20%) and high (30%) lipid diets were manufactured and fed market-size triploid rainbow trout (∼3.2 kg) for 77 days. Results showed that the width of the myosepta (MS) was significantly increased, and nonanal, (E, Z)-2,6-nonadienal, octanal, 1-octen-3-ol, and hexanal emerged as the top five contributors to the overall odor profile of the fish fillets, following exposure to the high-lipid (HL) diet. Lipidomic profiling demonstrated that triglycerides (TG) were the predominated lipid class in both muscle fibers (MF) and MS fractions. The HL diet differentially modulated lipid composition: it upregulated TG content in MF, while reducing TG content and promoting the accumulation of phosphatidylcholine (PC) in MS. Gene expression analysis showed tissue-specific regulation of lipid metabolism. In MF, the upregulation of fatty acid binding protein 1 () and perilipin-3 (), and the downregulation of , peroxisome proliferator activated receptor α (), , acyl-CoA oxidase (), and carnitine palmitoyltransferase 1 (), were induced by the HL diet, which collectively promoted TG synthesis and storage, which may be one of the underlying mechanisms contributing to the formation of a more intense odor profile in MF. In MS, HL diet exposure induced the upregulation of , , , , and , and the downregulation of and , thereby promoting TG mobilization and catabolism, and stimulating PC accumulation, and represent a potential mechanism contributing to the increased width of MS. The findings of this study will lay a theoretical foundation for elucidating the quality formation and the heterogeneity of muscular lipid deposition in rainbow trout. - Source: PubMed
Publication date: 2026/01/11
Shen FenghuangHuang DongSun GuoliangWu ZezhongMa RuiMeng Yuqiong - Metabolic associated fatty liver disease (MAFLD) has currently emerged as the predominant form of chronic liver diseases nowadays, with a high morbidity. Nevertheless, the general remission rate of current treatments for MAFLD remains unsatisfactory. The traditional Chinese medicine formulation Xiaochaihu decoction (XCHD) alleviates triglyceride (TG) and total cholesterol (TC) in patients with fatty liver disease, but the precise mechanisms remain to be determined. - Source: PubMed
Publication date: 2026/01/20
Zhong YingZhu Xiao-MinLi Jian-ChaoSheng Li-SongQi Jia-YingShen Xian-HuiDu HangHuang Na-NaSun Rong - Lipid droplets (LDs) dynamically interact with other organelles, such as mitochondria, in surveillance of cellular metabolic homeostasis. The transient nature of LDs, however, poses technical challenges to snapshot molecular information underlying these interactions. Herein, we present a small-molecule-based photocatalytic protein proximity labeling method (named LipoID) to enable in situ labeling, capturing and profiling of the LD-interacting proteome. This method is enabled by a set of LD-targeting probes designed to catalyze protein modifications nearby LDs using nucleophilic substrates. Profiled by liquid chromatography-tandem mass spectrometry, LipoID identifies tethered interorganellar interactions, particularly with mitochondria, in addition to reliable capture of validated LD biomarkers (for example, perilipins (PLINs)). Coupled with comparative proteomics, LipoID discovers mitochondrial voltage-dependent anion channel 3 as a potential regulator of LD-mitochondria proximity through interacting with PLIN3 on LDs. Further metabolomics analysis suggested remodeled lipid metabolism in line with the LD-mitochondria interaction. Together, LipoID enables in situ profiling of the LD interactome and reveals interorganellar regulation. - Source: PubMed
Publication date: 2026/01/09
Guo HengkeWan WangHuang YananZhao NanWu CiZhong BowenSun RuiFeng HuanYan JingShen DiDong XuepengZhao QunZhang XinZhang LihuaLiu Yu