Ask about this productRelated genes to: DSG2 antibody
- Gene:
- DSG2 NIH gene
- Name:
- desmoglein 2
- Previous symbol:
- -
- Synonyms:
- CDHF5
- Chromosome:
- 18q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-15
- Date modifiied:
- 2019-04-23
Related products to: DSG2 antibody
Related articles to: DSG2 antibody
- Acute myocarditis has traditionally been regarded as an acquired inflammatory disorder of the myocardium, most commonly triggered by viral infection or immune-mediated injury. However, emerging evidence suggests that in a substantial subset of patients, myocarditis may represent the initial clinical manifestation of an underlying genetic cardiomyopathy rather than a purely inflammatory disease. Recent advances in molecular genetics, cardiac magnetic resonance (CMR) imaging, and translational pathology have highlighted a growing overlap between myocarditis and inherited cardiomyopathies, particularly those associated with desmosomal dysfunction. - Source: PubMed
Publication date: 2026/07/06
AbdelMassih Antoine FakhrySankari Anna CarininaMallouka GeorgeHattab Haya Sameh AhmadAbutaleb JumanaAlbalooshi MeeraAbukhater ReemKhan Shirin - Keratins (CK) and desmosomal proteins are associated with prognosis in many cancers, and CK5, CK14 and CK20 are recognized as surrogate markers for molecular subtyping of muscle-invasive bladder cancer (MIBC). We analyzed the correlation between protein clustering and MIBC subtypes. We retrieved samples of muscle-invasive UC from patients treated with radical cystectomy without prior neoadjuvant therapy at two institutions. Immunohistochemical staining with tissue microarrays was performed for keratins (CK5, CK7, CK8, CK10, CK13, CK14, CK17, CK18, CK19, CK20), desmogleins (DSG2, DSG3) and desmocollin 3 (DSC3), and outcomes were evaluated using the H-Score. Molecular classification subgroups were defined according to CK5 and CK20 expression; for a subset of cases, the MDACC molecular classification was also available. Clinical data were retrieved from medical records. Hierarchical clustering with Euclidean distance, classification trees and principal component analysis was used for data visualization. We identified protein clustering patterns for luminal and basal subtypes in 232 analyzed samples. DSG2 groups were independent from DSC3 and DSG3 clustering in the luminal subtype. The molecular clusters were comparable in matched primary tumour and lymph node metastases (LNM) samples, and the protein expression correlated moderately with each other. CK5 (PT (90 [IQR 8.3-265, LNM (30.8 [IQR 6.7-155]; p = 0.011)), CK17 (PT (145 [IQR 42.5-222.5]),LNM (47.5 [IQR 14.2-110]; p = 0.005), DSG2 ( PT (55 [IQR 15-105]), LNM (32.1 (7.5-75.8)); p = 0.004), and DSC3 (PT (20.8 [IQR 0-71.7]), LNM (3.8 [IQR 0-43.3]; p = 0.013) expression were lower in LNM. Limitations include the absence of patients treated with neoadjuvant therapy and the risk of overfitting. We concluded that distinct keratin and desmosomal protein patterns are linked to cancer subtypes, and remain consistent in LNM. These findings indicate potential for keratins and desmosomal proteins to guide muscle-invasive bladder cancer subtype classification with possible prognostic implications, necessitating further research. - Source: PubMed
Publication date: 2026/07/06
Scherping Anna KatrinTomasik BartłomiejLuzha JetonSchostak MartinJandrig BurkhardFehr AlexanderHartmann ArndtAbele NiklasEckstein MarkusStröbel PhilippMiszczyk MarcinShariat Shahrokh FKunc MichalGarbers ChristophCzapiewski Piotr - Maternal recognition of pregnancy (MRP) in the mare requires coordinated adaptations of both the conceptus and the endometrium during the peri-recognition interval; however, integrated transcriptomic analyses of both compartments within the same biological window remain limited. Here, we analyzed conceptus RNA-seq data across embryonic age (Days 8 and 12 post ovulation) and endometrial RNA-seq data across pregnancy status (pregnant versus non-pregnant mares sampled between Days 8 and 12 post ovulation). In pregnant mares, conceptus recovery and endometrial biopsy collection were performed within the same gestation, allowing biological integration of embryo and maternal transcriptomes while preserving tissue-specific statistical contrasts. - Source: PubMed
Publication date: 2026/06/18
Da Silva Álvarez EvaOrtiz-Rodríguez José MMartín-Cano Francisco EÁlvarez-Barrientos AlbertoBecerro-Rey LauraGil María CRedondo EloyMasot JavierAparicio Inés MPeña Fernando JOrtega-Ferrusola Cristina - The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and characterized 78 detailed cell types in the macaque AIC, revealing the diversity and specialization of this region in cell type, connectivity profile, signal-processing strategy and metabolic characteristics. Among these, we identified two transcriptomically and morphoelectrically defined von Economo neuron (VEN) subtypes, DSG2-expressing VEN-L and POC5-expressing VEN-S, transcriptomically relating to extratelencephalic and corticothalamic projection neurons, respectively. We also uncovered a previously underappreciated signal-processing strategy by VENs, whereby the geometry of the dendrite-originating axon reshapes action potential dynamics and enhances somatic responsiveness to deep-layer synaptic inputs. Our multimodal atlas establishes a molecular and functional framework for investigating the circuit principles underlying cognitive processes in the primate AIC. - Source: PubMed
Publication date: 2026/07/02
Liu Rui-FengHuang MengyaoShen YuhuiShao MingtingJing JunzhanXu NanaTang LeiLiu BiaodiShi JianmingChen FanruiHao Zhao-ZheJiang XiaolongLiu Sheng - Pathogenic variants in desmoglein-2 () are a major cause of arrhythmogenic cardiomyopathy (ACM), a disease plagued by ventricular arrhythmias, contractile dysfunction, myocardial inflammation, and fibrofatty remodeling. Additionally, increasing evidence implicates mitochondrial dysfunction in -associated disease. However, whether mitochondrial remodeling occurs uniformly across ventricles remains less well defined. Here, we utilized a homozygous mutant () mouse to define chamber-specific mitochondrial remodeling in -linked ACM. Re-analysis of our previously generated cardiomyocyte snRNAseq dataset revealed broad downregulation of mitochondrial transcripts involved in fusion/fission dynamics, calcium handling, mitophagy, structural organization, and electron transport chain (ETC) assembly, findings that are consistent with impaired mitochondrial homeostasis and bioenergetic capacity. Ultrastructural analyses by transmission electron microscopy showed that hearts contained an increased number of mitochondria, which were smaller, irregularly shaped, and more disorganized than wildtype (WT) counterparts. Importantly, these alterations were chamber-dependent, with the right ventricle (RV) displaying more pronounced reductions in mitochondrial circularity and greater mitochxondrial abundance than the left ventricle (LV), indicating increased RV susceptibility. Together, these findings unveil mitochondrial remodeling as a feature of DSG2-deficiency and support a desmosomal-mitochondrial axis in ACM pathogenesis, further supporting mitochondrial pathways as candidate therapeutic targets. - Source: PubMed
Publication date: 2026/06/27
Gonçalves AlexandreZhelan Chen ElaineRastegarpouyani HosnaAraújo Fernandes AuréliaN Alves InêsSequeira VascoKwon ChulanChelko Stephen PLandim-Vieira Maicon