Ask about this productRelated genes to: CDK2 antibody
- Gene:
- CDK2 NIH gene
- Name:
- cyclin dependent kinase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-28
- Date modifiied:
- 2016-06-10
Related products to: CDK2 antibody
Related articles to: CDK2 antibody
- -Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the central nervous system and is involved in the development of neural tissue as well as the regulation of its functions. Meanwhile, GABA has also been demonstrated to confer multiple physiological benefits, including alleviating stress and improving metabolic homeostasis. This study investigated GABA effects on proliferation, differentiation, and temperature stress protection of bovine skeletal muscle satellite cells (BSCs). - Source: PubMed
Publication date: 2026/04/14
Manzoor AbidNaseem SajidaFu ZhiqiRuan ChaohuiLiu XuYan ChunriChoi SeonghoLi Xiangzi - The oncogenic potential of pituitary tumor-transforming gene-1 (PTTG1) has been well-documented in multiple cancer types. This study explored the biological role and molecular mechanism of PTTG1 in retinoblastoma. - Source: PubMed
Publication date: 2026/04/29
Feng JunliYe YunpengCheng FurongWu Yanping - Although polysaccharides from Polygonatum cyrtonema Hua have long been considered promising bioactive components, their antitumor effects have remained insufficiently defined. In this study, a homogeneous polysaccharide, PHP-1, was isolated and purified from Polygonatum cyrtonema Hua. Its structural characteristics and anti-tumor activity were analyzed. Structural characterization showed that PHP-1 was a branched fructan with a relatively narrow molecular weight distribution. In vitro experiments revealed that PHP-1 significantly inhibited the proliferation of several tumor cell lines, with the most pronounced effect observed in A375 cells. Additionally, in vitro experiments demonstrated that PHP-1 induced cell cycle arrest and apoptosis by modulating the expression of key regulatory proteins, including CDK2, Cyclin A2, Bax, and Bcl-2. In vivo studies further confirmed that PHP-1 promotes apoptosis and effectively inhibits tumor growth in tumor-bearing mouse model. This study provides preliminary insights into the potential role of the newly identified homogeneous polysaccharide PHP-1 in cancer therapy, offering a theoretical foundation for the high-value utilization of Polygonatum cyrtonema Hua in anticancer research and related functional products. - Source: PubMed
Publication date: 2026/04/27
Gao LeileiSong LuJi JunhaoYang SusuWang FangChen JinfengLiu DongWang WeiHan Bangxing - Invasive infections caused by have high mortality rates, even when treated with the first-line agent voriconazole. The global emergence of azole resistance further increases treatment failure, underscoring the urgent need for antifungals with novel mechanisms of action. The fungal cell cycle is essential for viability and represents an attractive but underexplored target. In , progression from G2 to M phase requires interaction between the phosphatase NimT and cyclin-dependent kinase NimX. Here, we characterize the role of this interaction and its inhibition by 2-fluoro-4-hydroxybenzonitrile (compound 1), a small molecule that targets the human Cdc25B-Cdk2 interface. Using mutagenesis, we show that NimT residues Arg438 and Arg442 are critical for NimT-NimX binding and confirm they are essential for viability. A co-immunoprecipitation assay demonstrates that compound 1 disrupts the interaction, while live-cell imaging shows that this inhibition arrests cell cycle progression. Our findings provide mechanistic insight into fungal mitosis and highlight cell cycle regulators as promising antifungal drug targets.IMPORTANCEInvasive aspergillosis has high mortality and limited treatment options, threatened by rising drug resistance. Targeting the fungal cell cycle represents an unexplored strategy for antifungal drug development. The dynamic interaction between NimT and NimX is critical to the fungal duplication cycle. Here, we show evidence that, unlike in , relocation of NimT from the nucleus to the cytoplasm mid-interphase is the switching event that causes activation of NimX and allows the cell cycle to progress. We also show that disruption of the NimT-NimX interaction can be achieved using a reversible small-molecule inhibitor that arrests the fungal duplication cycle, highlighting mitotic regulators as promising antifungal drug targets. - Source: PubMed
Publication date: 2026/04/29
Storer I S RThornton B PHackett A STabernero LBromley M J - Pediatric acute myeloid leukemia (AML) is biologically distinct from adult AML and carries a poor prognosis. OVCA2, a serine hydrolase with context-dependent roles, has unknown function in AML. We aimed to investigate its role, regulation, and clinical significance in pediatric AML. - Source: PubMed
Publication date: 2026/04/28
Jiao WanyanCheng SaisaiYang XiaoLiu HaiyanTang XiaodongLi QianlongLi YingZhou Bi