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- Hepatic steatosis is a precursor to metabolic dysfunction-associated steatohepatitis (MASH), which is linked to obesity and diabetes and poses a risk for liver cirrhosis and cancer. For detecting MASH and hepatic steatosis, liver biopsy is the reference method, but it is invasive and impractical for repeated monitoring of treatment efficacy. Our goal was to develop a convenient and non-invasive tool for accurately identifying MASH and steatosis grade in people with obesity. - Source: PubMed
Publication date: 2026/05/14
Zhang HailongJiang ZhuoruZheng HuanhuanWang HaoyaoXia LiankunChen JunZhang Bing - Identifying meaningful changes in comfort and any underpinning biomechanical changes is crucial to understanding differences in perceptions of footwear comfort. Research rarely considers changes in comfort, and rarely reports how meaningful these are. This study aims to utilise a portable biomechanics measurement tool to establish whether commercially available insoles make meaningful changes in comfort and identify any concurrent changes in biomechanics compared with a control whilst worn during a users' normal day. - Source: PubMed
Lewin MaxJones RichardPrice Carina - This study aims to assess pharmacists´ self-perceived knowledge or competence of major geriatric topics and skills, the perceived relevance of these to work or clinical practice, and their interest in receiving further education or training. - Source: PubMed
Publication date: 2026/05/14
Harasani KlejdaOgliari GiuliaSoraci LucaPiotrowicz KarolinaDuque SofiaGugu MitildaStefanović KatarinaKotsani Marina - Peroral endoscopic myotomy (POEM), a newly invented treatment for patients with achalasia, has achieved great success; however, for the rarest manometric subtype (type III), its efficacy remains unknown. We aimed to evaluate the efficacy of peroral endoscopic myotomy (POEM) for type III achalasia. - Source: PubMed
Publication date: 2026/05/14
Dai YanMa YizeLi XueyanWang ShaotongZhang QingqingWu JiandiFang JianhuaWang ZheTian WenjingJin KangjiaLi GangpingXiang XuelianSong Jun - Schistosomiasis, a parasitic disease transmitted by freshwater snails, affects over 251.4 million people globally, with sub-Saharan Africa bearing 95% of the disease burden. This study evaluates the phytochemical composition, characterizes the bioactive secondary metabolites, antioxidant, anti-inflammatory, and the cercaricidal properties, as well as the biosafety of the methanolic and hexane extracts of Chromolaena odorata. Phytochemical screening of C. odorata extracts identified tannins, flavonoids, and saponins in the methanolic extract and steroids and alkaloids in the hexane extract. LC-MS and HPLC-UVESI-TOF-MS analyses confirmed the presence of polyphenols (flavonoids) and aromatic dicarboxylic acid compounds. Antioxidant analysis revealed strong free radical scavenging potential of the plant extracts. Both extracts demonstrated potent cercaricidal activity against Schistosoma mansoni, with LC values as low as 0.2012 and 0.2410 μg/mL, respectively. The anti-inflammatory effects were determined via inhibition of heat-induced albumin denaturation, with plant extracts able to inhibit protein denaturation, particularly the methanolic extract that shows a percentage of inhibition of 73.56% at the highest concentration tested. Cytotoxicity assays on LLCMK2 cells showed low toxicity of the extracts. These findings suggest that crude C. odorata extracts possess antischistosomal, antioxidant, and anti-inflammatory properties, supporting their potential integration into primary healthcare strategies for schistosomiasis control. - Source: PubMed
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