Ask about this productRelated genes to: CEBPB antibody
- Gene:
- CEBPB NIH gene
- Name:
- CCAAT enhancer binding protein beta
- Previous symbol:
- TCF5
- Synonyms:
- LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-27
- Date modifiied:
- 2018-02-23
Related products to: CEBPB antibody
Related articles to: CEBPB antibody
- Elevated intra-tissue levels of active glucocorticoids in patients with obesity are associated with insulin resistance, diabetes, impaired immune regulation, and other adverse effects. Sleeve gastrectomy (SG) induces significant weight loss and improves metabolic outcomes, including insulin resistance and hyperlipidemia. Among the enzymes controlling intracellular concentrations of active glucocorticoids, 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1, SDR26C1) has been extensively studied concerning obesity and post-gastric surgery interventions. However, most studies focused on either a single tissue, circulating glucocorticoid levels, or HSD11B1 activity. In this work, we showed that the circulating active/inactive glucocorticoid ratio (corticosterone (B)/11-dehydrocorticosterone (A)) negatively correlated with glucose tolerance. In male C57BL/6 mice, SG slightly reduced circulating mineralocorticoids and reversed the elevated B/A ratio seen in sham-operated mice after high-fat diet, while improving glucose tolerance. This change was likely due to increased renal 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2, SDR9C3) activity after SG. To provide a comprehensive overview of the systemic effects post-surgery, we evaluated enzymes involved in glucocorticoid homeostasis across tissues on mRNA, protein, and activity levels. Moreover, mRNA expression levels of transcription factors CCAAT enhancer-binding protein alpha (), , and nuclear factor kappa b ( ), as well as cytokines influencing and gene expression, were analyzed. The results emphasize stronger influence of renal HSD11B2 than hepatic HSD11B1 activity on the circulating B/A ratio, supported by intrarenal and intrahepatic B/A ratios. The improved glucocorticoid homeostasis following SG, indicated by decreased B/A ratios, proposes a lower risk of glucocorticoid-mediated adverse health effects, including chronic kidney disease, hypertension, and metabolic disturbances. - Source: PubMed
Publication date: 2026/05/15
Moser Seraina OMoscalu AndreiRoberts Cullen FSpäne Philipp MWinter Denise VJoos Friedrich LGómez CristinaSheu Eric GOdermatt Alex - Foam cell formation is a critical early event in atherosclerosis. While oxidized low-density lipoprotein (oxLDL)-driven mechanisms are well studied, the contribution of free fatty acids (FFAs), particularly under high-fat dietary intake, is less defined. CCAAT/enhancer-binding protein β (C/EBPβ), a transcription factor regulating macrophage lipid metabolism, has been implicated, but its epigenetic role in FFA-induced lipid accumulation remains unclear. - Source: PubMed
Publication date: 2026/04/29
Wang GangZhu YifanLiu YangHuang WeiWei YihuaLiu YuanLiu BinbinSu Li - Diabetic retinopathy (DR) is driven by chronic hyperglycemia and involves coordinated vascular, inflammatory, and neuroglial dysfunction. Müller glia are central to retinal homeostasis, yet their cell-state heterogeneity and inflammatory response programs in DR mice remain incompletely characterized at single-cell resolution. - Source: PubMed
Publication date: 2026/04/29
Ouyang ShuaiWang JingwenDu XiaolanZhang ShouyueHan ShijunXu XiaotongRen BeichenYu Weihong - This study aimed to identify pyroptosis-related hub genes and investigate immune cell infiltration in IgA nephropathy (IgAN) using bioinformatics and experimental validation. Gene expression data from the GEO database (GSE93798) were analyzed, and differential expression analysis was performed using the limma R package. LASSO regression and SVM algorithms were employed to select feature genes. A total of 19 pyroptosis-related differentially expressed genes (nine up-regulated and 10 down-regulated) were identified, with six hub genes (BHLHE40, JUN, CEBPB, ACE2, IL1B, and CD14) showing high diagnostic accuracy for discriminating IgAN from normal samples (AUC > 0.9). Gene Ontology (GO) and KEGG analyses revealed involvement in immune response, cell migration, and inflammation-related signaling pathways. Immune cell infiltration analysis showed higher levels of CD8+ T cells, macrophages, and neutrophils in IgAN. Validation using GSE99339 confirmed these findings, with the hub genes also demonstrating high AUC values in this independent dataset. The differential expression of these genes was validated in both human kidney tissues and serum samples. This study provides potential biomarkers and therapeutic targets for IgAN by elucidating pyroptosis-related genes and immune cell infiltration profiles. - Source: PubMed
Publication date: 2026/05/14
Li JiayiZhou ChengShang ShunlaiXu QianqianLi Wenge - Acute neuroinflammation drives secondary degeneration after spinal cord injury (SCI), yet the precise immune cell states and upstream regulatory circuits that initiate this response remain unresolved. Defining these early-state determinants at multi-omics resolution is essential for identifying mechanistically grounded therapeutic targets. - Source: PubMed
Publication date: 2026/05/14
Wang HaojueWu HaoranLi ZhixuanHuo YimingLi BoLiu WanghuiZhai XiaoChen KaiLiu Yang