Ask about this productRelated genes to: PAX8 antibody
- Gene:
- PAX8 NIH gene
- Name:
- paired box 8
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-16
- Date modifiied:
- 2017-07-07
Related products to: PAX8 antibody
Related articles to: PAX8 antibody
- Pulmonary lymphangitic carcinomatosis (PLC) is a rare manifestation of renal cell carcinoma (RCC) that can mimic benign interstitial lung disease, creating a significant diagnostic pitfall. This case report highlights how such a misinterpretation led to inappropriate surgical management and underscores the importance of a biopsy-first approach in suspected metastatic RCC. This report follows the SCARE 2025 Checklist. - Source: PubMed
Publication date: 2026/04/08
Debiche SoumayaCherif HelaRjeb Sarra BenSalma MokaddemYangui FerdaousCharfi Mohamed Ridha - The middle ear is an anatomic region that many pathologists may not feel comfortable reviewing. A variety of neoplastic and non-neoplastic lesions may occur in this anatomically complex space, but specimens are uncommon so the full spectrum of alterations remains obscure. This study was prompted by anecdotally encountered cases of unexpected S100 and PAX8 expression in middle ear specimens which led to diagnostic confusion. Twelve cases of otitis media were studied. In each case there was no clinical or radiological suspicion for neoplasia. Immunohistochemistry for S100 and PAX8 were performed on each case, with SOX10 and CD1a also done on a subset. Varying degrees of S100 immunoexpression was seen in the middle ear stroma of 12 cases, while the same cells were negative for SOX10 (0 of 11) and CD1a (0 of 3) in all cases tested. PAX8 was positive in the cuboidal middle ear epithelium in 11 of 11 tested cases. Expression was seen both in the lining surface components as well as in areas of glandular metaplasia. S100 is unexpectedly positive in middle ear stroma, a finding which can lead to diagnostic confusion, particularly for nerve sheath tumors. PAX8, on the other hand, is unexpectedly positive in middle ear epithelium, a pitfall for diagnosing various neoplasms, especially endolymphatic sac tumor of the inner ear. Awareness of these immunoexpression patterns will help avoid misdiagnoses. In particularly difficult cases, additional immunohistochemistry and clinical/radiographic correlation can clarify the diagnosis. - Source: PubMed
Publication date: 2026/05/11
Kurian Elizabeth MIsaacson BrandonHunter Jacob BSaluja KaranGibbs Paul MBishop Justin A - To investigate the clinicopathological characteristics, differential diagnoses, and prognostic implications of uterine metastasis originating from lung adenocarcinoma. - Source: PubMed
Publication date: 2026/05/13
Haiyun YuWenxue ZhiChunyan HePingping ZhongYulan Jin - Cystic nephroma (CN) is a rare, benign renal tumor often misdiagnosed due to overlapping radiological features with simple renal cysts and malignant cystic neoplasms. CN primarily affects boys and adult females. This study aimed to review the clinical, imaging, and pathological characteristics of CN to improve diagnostic accuracy. - Source: PubMed
Publication date: 2026/04/23
Zi Guo RunZhang Da-JiangHe Dong-LinChai Jia-GuiKe Chang-XingFeng Run-Lin - The clear cell variant of papillary thyroid carcinoma (CLCVPTC) is an exceedingly rare and diagnostically challenging subtype of papillary thyroid carcinoma (PTC), defined by distinctive histomorphologic features. Here, we aimed to delineate the clinicopathologic, immunohistochemical, and molecular genetic characteristics of CLCVPTC by retrospectively analyzing four pathologically confirmed cases diagnosed at our institution between 2018 and 2025, together with a comprehensive review of the published literature. The male to female ratio of the four CLCVPTC cases is 1: 3, with a median age of 60 years (range 45-68) and presented clinically with thyroid nodules. Histopathological evaluation demonstrated infiltrative tumor growth patterns with solid, trabecular, and focal papillary architectures. Tumor cells displayed abundant clear cytoplasm (more than 90% of all tumor cells in our cases, meeting the diagnostic threshold of >50%) and classic nuclear features of PTC, including ground-glass nuclei, nuclear grooves, and intranuclear inclusions. Lymph node metastases were observed in three cases. Immunohistochemical profiling revealed consistent positivity for TTF-1, Pax8, CK7, thyroglobulin (TG) and Galectin-3, and absence of expression for TPO, BRAF V600E mutation, and various neuroendocrine markers. Polymerase chain reaction (PCR) identified an gene fusion in 50% (2/4) of the cases. All patients underwent thyroidectomy and central lymph node dissection, among which three of them also underwent contralateral thyroidectomy, with no evidence of disease recurrence during follow-up periods ranging from 2 to 54 months. However, due to the short follow-up for some cases and the loss to follow-up, long-term outcomes for CLCVPTC remain undefined. In conclusion, CLCVPTC is a rare variant of PTC characterized by distinctive clear-cell change with canonical PTC nuclear features. The detection of an fusion in half of our cases suggests a recurrent genetic alteration that may contribute to its pathogenesis, though this finding requires validation in larger cohorts. - Source: PubMed
Publication date: 2026/04/23
Xu LiLuo BinWang QianwenLiu WenKe XiaokangYuan Jingping