Ask about this productRelated genes to: MYOD1 antibody
- Gene:
- MYOD1 NIH gene
- Name:
- myogenic differentiation 1
- Previous symbol:
- MYF3
- Synonyms:
- PUM, MYOD, bHLHc1
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-07-22
Related products to: MYOD1 antibody
Related articles to: MYOD1 antibody
- The progressive skeletal muscle degeneration observed in Duchenne Muscular Dystrophy (DMD) patients requires multiple cycles of satellite cells (SCs) activation to promote tissue regeneration. Dystrophic SCs present intrinsic defects, and the disrupting fibrotic niche hinders appropriate muscle recovery. Traditional 2D culture systems face challenges in modeling the DMD muscle niche and SCs behavior. Our aim was to validate a 3D culture of skeletal muscle spheroids (iSMS) for DMD modeling, as compared to the traditional 2D culture, while investigating the pathophysiological mechanisms of dystrophin deficiency in vitro. - Source: PubMed
Publication date: 2026/05/02
Esposito Joycede Souza Leite FelipeBarbosa Igor Nevesda Mata Martins Thaís Mariade Oliveira Olberg Giovanna GonçalvesAl Tanoury ZiadTelles-Silva Kayque Alvesda Silva Pardo Mayana CristinaJazedje TatianaBortolin Raul HernandesHirata Mario HiroyukiPourquié OlivierZatz Mayana - Renal-pelvic fibroepithelial polyps (FEPs) are rare benign mesodermal lesions that can radiologically and clinically mimic urothelial carcinoma, sometimes prompting radical surgery. We reviewed five consultation cases of renal pelvis or proximal-ureter FEPs, integrating histology, immunohistochemistry, and targeted molecular testing. Patients were all females, tumors measured 3.3-9.0 cm (mean 5.2 cm), and four arose in the renal pelvis with variable ureteral extension. Three patients underwent nephroureterectomy for presumed malignancy. Histologically lesions shared a polypoid architecture with fibrovascular cores lined by benign -appearing urothelium; stromal cellularity separated lesions into hypercellular (patients 1-2) and hypocellular stromal patterns. Hypocellular lesions displayed fibrocollagenous stroma with bland spindle cells and were lined by benign urothelium. Hypercellular examples showed epithelioid smooth muscle type or primitiveappearing-stromal proliferations with occasional mitoses and focal Ki-67 elevation but lacked significant atypia, necrosis, infiltrative growth, or lymphovascular invasion. Immunoprofiles confirmed urothelial epithelial differentiation (AE1/AE3, GATA3, PAX8) with areas of anastomosing cords and pyelitis cystica and variable stromal labeling for desmin, CD10, ER, and PR; myogenin/MyoD1 were negative. A fusion/cancer gene- NGS panel (including GLI1 and NCOA1/2) was negative in the tested case. No recurrences were observed with mean followup of 24 months. We emphasize distinguishing features from papillary urothelial carcinoma, mixed -epithelialstromal tumor/smooth muscle adenoma-like renal tumor (SMART), rhabdomyosarcoma, and -translocation associated mesenchymal neoplasms, noting that focal -fibroadenoma like- stromal areas can occur in FEPs. Recognition of the confined polypoid growth beneath intact urothelium, bland cytology, supportive immunohistochemistry, and selective molecular testing when stromal atypia raises concern, can avoid misclassification and unnecessary radical surgery. - Source: PubMed
Publication date: 2026/04/28
Zhang Guan-NanEugene Henrietta CArgani PedramBaraban Ezra GGross John MMatoso Andres - Anorectal malformation (ARM) is the most common congenital digestive tract anomaly in newborns, and children with ARM often have varying degrees of underdevelopment of the pelvic floor muscles (PFMs). To explore the effects of Rarα (NR1B1) and Pitx2 on the development of rat PFMs, we constructed a rat ARM animal model using all-trans retinoic acid (ATRA), and verified the expression of Rarα and Pitx2 in the PFMs of fetal rats. Additionally, we used rat myoblasts (L6 cells) to investigate the regulatory roles of Rarα and Pitx2 in skeletal muscle myoblast differentiation and their interactions. The results indicated a significant decrease in the expression of Rarα and Pitx2 in the PFMs of fetal rats with ARM. ATRA can also decrease the expression of Rarα and Pitx2 in the L6 cells, while affecting the differentiation and fusion of L6 cells. Knocking down Rarα in L6 cells reduced the expression of Pitx2, Myod1, Mymk, and decreased myogenic activity in L6 cells. When Rarα is activated, the decreased expression of Pitx2, Myod1, and Mymk and myogenic differentiation can be restored to different extents. At the same time, increasing or inhibiting the expression of Pitx2 can counteract the effects of knocking down Rarα and activating Rarα respectively. These results indicate that Pitx2 may be downstream of the transcription factor Rarα, mediating the effects of ATRA on the development of fetal rat PFMs. - Source: PubMed
Publication date: 2026/04/17
Zhao HanbinCao JianMu HuaqiBi YangGuo ZhenhuaShi YuanWang Yi - Spindle cell and sclerosing rhabdomyosarcoma (Sc/SRMS) are rare histologic subtypes of rhabdomyosarcoma, increasingly recognized for their distinct molecular profiles and aggressive clinical behavior. Retroperitoneal involvement is exceptionally uncommon and poorly characterized. To characterize the clinical, pathological, and molecular features of retroperitoneal Sc/SRMS through a combined institutional case series and individual patient data (IPD) meta-analysis. - Source: PubMed
Publication date: 2026/04/01
Zhang XiaoyingZheng HainingZhang Ming - IntroductionPrimary sarcoma of the prostate is extremely rare and accounts for less than 1% of all prostatic malignancies. Alveolar rhabdomyosarcoma arising from the prostate in an adult man is exceedingly rare. Establishing a correct diagnosis is often challenging in a prostatic core biopsy.Patient presentationA 30-year-old man presented to the emergency department after a period of acute urinary retention. Clinical examination revealed an indurated prostatic mass. Serum prostate-specific antigen level was normal. Imaging work-up showed pelvic lymph node and vertebral metastases. A malignant pleural effusion was noted. Transrectal ultrasound-guided core biopsy from the prostate revealed a cellular malignant neoplasm with small round tumor cells arranged in nests and sheets. Initial diagnosis of prostatic adenocarcinoma, Gleason score 5 + 5, grade group 5 was made. Immunohistochemical work-up showed positive skeletal muscle markers (desmin, myogenin and MYOD1) with negative keratin (AE1/AE3), NKX3.1, synaptophysin, chromogranin. CD56 showed patchy positivity. A revised diagnosis of primary alveolar rhabdomyosarcoma was established. The patient succumbed to the disease soon after the diagnosis.DiscussionPrimary alveolar rhabdomyosarcoma of the adult prostate has been rarely reported. The tumor has an aggressive clinical course with dismal prognosis. The diagnosis can be challenging as the histomorphology closely resembles poorly differentiated carcinoma, non-Hodgkin lymphoma, small cell carcinoma and other small round cell sarcomas. Aberrant immunohistochemical expression causes diagnostic dilemma. The treatment protocol and adjuvant drugs differ significantly from prostatic adenocarcinoma or small cell carcinoma, necessitating an accurate histological diagnosis for appropriate patient management. A molecular work-up can be useful in challenging specimens. - Source: PubMed
Publication date: 2026/04/16
Mitra SaikatChoube AbhishekRatnaparkhi ChetanaPande Shantanu