Ask about this productRelated genes to: CRTC1 antibody
- Gene:
- CRTC1 NIH gene
- Name:
- CREB regulated transcription coactivator 1
- Previous symbol:
- MECT1
- Synonyms:
- KIAA0616, FLJ14027, TORC1
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-01
- Date modifiied:
- 2016-10-05
Related products to: CRTC1 antibody
Related articles to: CRTC1 antibody
- Axillary lymph nodes are a common site of metastatic carcinoma, particularly from the breast. Epithelial inclusions within axillary lymph nodes are uncommon but well recognized, most frequently encountered as small, incidental clusters of mammary-type epithelium; squamous, Müllerian, and mixed types are also sporadically identified. Hidradenoma is a benign adnexal neoplasm classically composed of epidermoid/squamoid, intermediate/basaloid, and mucinous cells that most commonly originates in the skin but can arise in the breast parenchyma, with morphologic and genetic features that overlap with mucoepidermoid carcinoma. Rare instances of hidradenomas within pelvic and axillary lymph nodes have been reported, raising the specter of metastasis. We report 3 cases of axillary lymph node hidradenoma presenting without a concurrent breast or cutaneous lesion. Morphology, immunohistochemistry, and molecular studies were evaluated. Two cases were found to harbor CRTC1::MAML2 rearrangements, while a rarer CRTC3::MAML2 fusion was identified in a third case. Following excision, the 3 patients were without evidence of residual disease, with clinical follow-up of ∼2 years each. Recognition of this entity is essential to avoid misclassification as metastatic carcinoma and prevent overtreatment. - Source: PubMed
Publication date: 2026/04/23
Bean Gregory RKingsley Leandra GTan JenniferRutland Cooper DLin RachelBridge Julia APatel Paras BVohra PoonamKrings GregorChen Yunn-Yi - CRTC1::TRIM11 cutaneous tumors are an emerging subset of MITF pathway-activated neoplasms that typically present as dermal nodules and can closely mimic clear cell sarcoma or malignant melanoma. Most reported tumors behave in an indolent manner, yet rare malignant cases have been documented. We report three additional CRTC1::TRIM11 cutaneous tumors with atypical features, including two patients with nodal or visceral disease at presentation. Histologically, all three tumors showed marked cytologic atypia with prominent nucleoli, and the usual nested and short-fascicular architecture was largely replaced by broad sheet-like growth, raising concern for melanoma. The tumors expressed SOX10 (diffuse) and S100 protein (patchy) with focal to absent expression of Melan-A and HMB45. PRAME was negative. CRTC1::TRIM11 was confirmed in all tumors. Two tumors harbored TERT promoter mutations, and one showed additional low-level copy-number gains of 1q, 8q, and 12q with 14q loss. In one case, methylation profiling yielded a clear cell sarcoma score of 0.885, just below the confidence threshold, likely due to shared CREB-MITF pathway activation and the lack of a dedicated CRTC1::TRIM11 reference class. A literature review identified nine previously reported metastatic CRTC1::TRIM11 cutaneous tumors. When combined with our series, extremities were the predominant primary site, and metastases most often involved regional lymph nodes and the lung. Fusion status remains the molecular gold standard, while secondary events such as TERT promoter mutations and 8q gains may contribute to aggressive behavior in a subset of tumors. - Source: PubMed
Batson BethanyKarunamurthy ArivarasanNeyaz AzfarSkaugen John MBillings Steven DFritchie KarenJohn Ivy - The 5th edition of the World Health Organization (WHO) classification of skin tumors introduces a dedicated chapter on cutaneous soft tissue tumors, providing a comprehensive, standardized reference with updated diagnostic criteria that directly inform routine dermatopathology practice and molecular diagnostics. This edition incorporates several key changes, including newly recognized entities such as EWSR1::SMAD3-rearranged fibroblastic tumor, neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasm, superficial CD34-positive fibroblastic tumor, and CRTC1::TRIM11 cutaneous tumor. Diagnostic terminology has also been refined; for example, the term 'atypical intradermal smooth muscle neoplasm' replaces 'cutaneous leiomyosarcoma' for lesions confined to the dermis, whereas the designation leiomyosarcoma is reserved for tumors with overt subcutaneous infiltration. In addition, epithelioid fibrous histiocytoma has been reassigned to the family of tumors of uncertain differentiation. This review summarizes the key updates and newly recognized entities in the chapter on cutaneous soft tissue tumors in the 5th edition of the WHO classification of skin tumors, emphasizing their clinicopathological and molecular implications. - Source: PubMed
Publication date: 2026/03/13
Choi Joon Hyuk - CRTC1 is highly expressed in the brain and functions as a coactivator of CREB, regulating transcription of genes essential for neuronal function and plasticity. To elucidate its role in the primate cortex, we performed CRTC1 knockdown using short hairpin RNA (shRNA) in the visual cortex (V1) of common marmosets (Callithrix jacchus). Unexpectedly, the knockdown caused widespread cFOS induction beyond the injection site. Concurrently, reduced NeuN expression, appearance of cell death markers, increased glial markers, and glial scarring were observed around the lesion. Longitudinal electrocorticography revealed transient perturbations in high-frequency oscillations (HFOs) across widespread cortical areas. MRI and histology confirmed lesion formation in the temporal lobe within months, followed by progressive degeneration near the injection site. Notably, glial and cell death marker changes appeared within one month, preceding or coinciding with IEG induction. These findings suggest that CRTC1 may exert neuroprotective effects by restraining neuronal hyperexcitability. We further discuss molecular pathways linking CRTC1 knockdown to sequential cell death and hyperexcitability leading to IEG and HFO induction. Our results provide new insights into the mechanisms underlying HFO regulation and neuroprotection in the primate cortex following localized knockdown of a transcriptional coactivator. - Source: PubMed
Publication date: 2026/03/11
Nakagami YukiKomatsu MisakoNakae KenOhtsuka MasanariHata JunichiMizukami HiroakiTakemori HiroshiIshii ShinOkano HideyukiWatakabe AkiyaYamamori Tetsuo - - Source: PubMed
Publication date: 2026/03/09
Fukuchi MamoruMaeda NatsumiHoshino SachieHuanood GegentuyaWatanabe Kazuki