Ask about this productRelated genes to: IGFBP2 antibody
- Gene:
- IGFBP2 NIH gene
- Name:
- insulin like growth factor binding protein 2
- Previous symbol:
- IBP2
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-09
- Date modifiied:
- 2015-11-12
Related products to: IGFBP2 antibody
Related articles to: IGFBP2 antibody
- Postmenopausal osteoporosis (PMOP) is characterized by high-turnover bone loss and oxidative stress. Astragaloside IV (AS-IV) exhibits antioxidant and immunomodulatory activities, yet its skeletal effects and mechanistic basis in ovariectomized (OVX) models remain incompletely defined. - Source: PubMed
Publication date: 2026/04/13
Li Ya-QingYao Xian-YingJing YanLiu Zi-YiWang Xing-WangLiang MingJiang Shuai-YuLu TaoChen ChenGao Yan-Ping - Fetal bovine serum (FBS) is a widely used but poorly defined mammalian cell culture supplement, introducing substantial batch-to-batch and grade-specific variability that compromises experimental reproducibility. We performed integrative proteomics and peptidomics profiling of three commercially available FBS grades using data-independent acquisition (DIA) mass spectrometry. A conserved core of 979 proteins shared across all grades was enriched for extracellular matrix organization, immune modulation, and growth factor regulation, explaining FBS's broad utility in standard cell culture. Differential abundance analysis revealed 88 proteins differing significantly between high-grade and low-grade products, while peptidomic profiling detected over 200 differentially abundant native peptide sequences. High-grade FBS was enriched in adhesion proteins (fibronectin, vitronectin, thrombospondin-1) and growth factor binding proteins (IGFBP2, IGFBP3), supporting robust cell attachment and proliferation, while low-grade serum exhibited elevated detoxification and oxidative stress response proteins consistent with a stress-adapted biochemical signature. Multiomics integration via DIABLO revealed coordinated proteolytic regulation distinguishing serum grades, with native peptides demonstrating greater intergrade divergence than intact proteins. These findings establish a molecular framework for rational serum selection and mass spectrometry-guided lot qualification in biotechnology and regenerative medicine, and identify functional modules structural scaffolding, carrier buffering, and bioactive peptide signaling that underpin FBS bioactivity and support the development of chemically defined culture media. - Source: PubMed
Publication date: 2026/04/27
Wijerathna-Yapa AkilaSokolenko Stanislav - Subacute rumen acidosis (SARA) is a critical metabolic disorder in dairy ruminants that threatens their milk production. However, the mechanisms by which rumen fungi influence the susceptibility and tolerance of ruminants to SARA remain unclear. This study investigated the relationship between rumen fungal metabolic functions and host SARA tolerance by examining the rumen epithelial miRNA-mRNA correlations and further cell subtype variations affected by fungi. SARA-susceptible and SARA-tolerant goats were identified by monitoring the dynamic rumen pH during high-concentrate feeding. The abundance of anaerobic fungi and their cellulose and amino acid metabolic functions were reduced in SARA-susceptible goats, but the enrichment of , which is associated with increased thiamine metabolism, offers potential for SARA tolerance. Furthermore, this study revealed that negatively regulates the rumen epithelial chi-miR-17-26080 through enhanced thiamine metabolism, thereby reducing its inhibitory effect on insulin-like growth factor binding protein 2 (IGFBP2). The tolerance mechanism of SARA was further explored by adding thiamine to high concentrations, which revealed that the upregulation of IGFBP2 promoted rumen epithelial IGF1 recruitment and increased the content of IGF1, which activated the ERK and PI3K/AKT pathways, further increasing the expression of CDK4 and Cyclin A2 and promoting the rumen epithelial cells' proliferation. The increased number of rumen spinous and basal cells in SARA-tolerant goats enhances volatile fatty acids absorption in dairy goats, leading to improved SARA tolerance. These findings highlight the roles of rumen fungi and their produced thiamine in preventing SARA in ruminants by enhancing epithelial cell proliferation via the IGFBP2/IGF1 axis activation. - Source: PubMed
Publication date: 2026/02/24
Xu JingyiChen XiaodongMa YiRen JianrongXu GuanghaoZhang PeilinJia WenhaoDeng QuanqiuXiao YuquanYao JunhuWu Shengru - Chronic kidney disease is associated with dysregulation of the insulin-like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF-I, IGF-II, IGFBPs and progression of kidney dysfunction remains unclear. We evaluated how IGF/IGFBP profile relates to longitudinal changes in urinary albumin/creatinine ratio (ACR) and serum creatinine level in people with type 2 diabetes (T2D). - Source: PubMed
Publication date: 2026/04/17
Heald AdrianLllangasekera YasithaMatheou AndreasNarayanan Ram PrakashWhite StephenHabte-Asres HellenaLay AbigailShalamanova LilianaOllier WilliamHitman Graham AMallik RitwikaKalra Philip AWhyte MartinGibson J Martin - - Source: PubMed
Publication date: 2026/04/10
He SiyiLiang ChunyanHuang QiqiTan XiangMeng JialiQin XinlingZhang YanLiao JiaqingSu GengWang RenshengHuang Weimei