Ask about this productRelated genes to: EphB1 antibody
- Gene:
- EPHB1 NIH gene
- Name:
- EPH receptor B1
- Previous symbol:
- EPHT2
- Synonyms:
- Hek6
- Chromosome:
- 3q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-03-23
- Date modifiied:
- 2016-01-15
Related products to: EphB1 antibody
Related articles to: EphB1 antibody
- Neuropathic pain after spinal cord injury reflects persistent hyperexcitability in the spinal cord dorsal horn, yet the molecular drivers sustaining this maladaptive state are unknown. Using an antibody microarray of dorsal horn tissue from mice six weeks after cervical contusion spinal cord injury, we found persistent upregulation of Eph-ephrin signaling, including increased EphB1, EphB2 and EphB3 expression and phosphorylation. Reversible chemogenetic inhibition of EphB kinase activity, using an EphB1/2/3 analog-sensitive knock-in mouse, selectively reversed established mechanical allodynia without affecting thermal hyperalgesia or motor function and also shifted dorsal horn signaling away from pain sensitization-associated pathways. Among EphB receptors, EphB2 showed the most consistent and robust injury-induced increase in expression within dorsal horn. Although EphB2 transcript levels increased in both dorsal horn neurons and astrocytes, conditional deletion of EphB2 only in dorsal horn neurons, but not in astrocytes, reversed established mechanical allodynia and reduced dorsal horn neuronal activation. These findings identify EphB signaling, and neuronal EphB2 in particular, as a mechanism that actively maintains pain hypersensitivity after spinal cord injury. - Source: PubMed
Publication date: 2026/04/22
Heinsinger Nicolette MJaffe David ASrikanth Kolluru DLyttle Megan ASmith Madison SThomas Samantha JCharsar Brittany ACheng LanMichel-Flutot PaulineCain Rachel EWatson Jaime LBao DuranFan JiaFalnikar AditiZhou WeiDalva Matthew BLepore Angelo C - Allium mongolicum Regel (AMR), a traditional edible and medicinal herb widely consumed in Asian cuisines, presents an important but understudied food safety concern due to its allergenic potential. This study bridges the gap between food science and health impacts by characterizing the first major allergen in AMR. Through an integrated approach combining transcriptome sequencing and immunological techniques, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a novel food allergen. The recombinant GAPDH protein exhibited clinically relevant IgE reactivity in 48.1% (13/27) of allergic individuals' sera, establishing its role in food allergy. Notably, we demonstrated that this food-derived allergen triggers distinct inflammatory pathways in human gastrointestinal (Caco-2) and respiratory (BEAS-2B) epithelial cells-key interfaces for food-host interactions. Transcriptomic analysis revealed tissue-specific responses: intestinal cells upregulated immunemodulatory genes (EPHB1, CD226, CD59), while lung cells activated interferon signaling, offering theoretical explanations for how dietary components may influence mucosal immunity. These findings significantly advance our understanding of herbal food allergies and pave the way for developing safer functional foods and targeted allergy management strategies. - Source: PubMed
Wang XiaoyanLiu YangZhou DongmeiLiao YuanfenMa XimengGong XinhuiCheng QiWang XueyanCui Yubao - The Circadian Imbalance Index (CII) integrates chronotype, sleep duration, neuroticism, caffeine intake, and vitamin D. In a genome wide association study (GWAS) of CII in 312,935 European ancestry UK Biobank participants, we identified 27 loci mapping to 72 genes, including circadian regulators CALCA, DHCR7, KDM5A, HAL, and CRX. Gene-overlap analyses demonstrated shared architecture with CII components, while EPHB1, SERPING1, C12orf74, PLEKHG7, and EEA1 were uniquely associated with CII. A CII polygenic score (CII-PRS) showed phenome-wide associations with type 2 diabetes (T2D), major depressive disorder, and obesity. Genetic correlations linked CII with insomnia, mood symptoms, body mass index (BMI), T2D, coronary artery disease (CAD), and myocardial infarction (MI). Mendelian randomization suggested causal effects of CII on T2D, mood swings, and MI, and reverse effects of CAD, mood, and MI on CII. This work shows that circadian imbalance is a polygenic trait connecting sleep-related biology to metabolic, cardiovascular and mood health outcomes. - Source: PubMed
Publication date: 2025/12/12
Żebrowska MagdalenaWielscher MatthiasZhang JingSaksvik-Lehouillier IngvildDiMilia LeeBurns AngusValliere JesseVincenzi LeonardoRedline SusanOkereke Olivia ISaxena RichaRichmond RebeccaRutter MartinSchernhammer Eva - T-cell large granular lymphocyte leukemia (T-LGLL) is a rare, indolent lymphoproliferative disorder of cytotoxic T cells in the peripheral blood, bone marrow, and spleen. This analysis was conducted to characterize genomic alterations and highlight potential therapeutic targets, with the goal of refining the molecular landscape of T-LGLL by emphasizing population-specific biomarkers. - Source: PubMed
Upadhyayula Bhanu SurabiSaglimbeni Grace SGobel EdieGobel AbbiMorris Tyson JSurendra AkaashHsia BeauSood AkshatTauseef Abubakar - Eph receptors and Ephrin ligands are a large highly conserved family of interacting membrane-anchored molecules that form dimers, tetramers, and tetramer superclusters to become activated and signal upon cell-cell contact. While most noted for their ability to transduce bidirectional phosphotyrosine signals in development, certain Ephs and Ephrins also become overexpressed and participate in pathological situations, including EphB1 in chronic pain/addiction and EphB2 in fibroinflammatory disorders and cancer. We searched for small molecules that disrupt EphB-EphrinB receptor-ligand interactions and discovered compounds with submicromolar activity that specifically inhibit formation of the tetramer. Compounds effectively target tetramer-driven EphB1-EphrinB2 and EphB2-EphrinB2 interactions, while showing less action towards the more dimer-driven EphB4-EphrinB2 interaction. They are orally available, exhibit drug-like qualities to reduce both EphB forward and EphrinB reverse signaling, and act to blunt inflammatory pain and opioid withdrawal behaviors. Tetramer inhibitors thus present a novel way to target Eph-Ephrin macromolecular interactions and counter pathologies caused or exacerbated by excessive bidirectional signaling. - Source: PubMed
Publication date: 2025/12/25
Wang HanghangKhambete AmavSprouse FrancesKarsi MelodyCortez KarinaBellinghausen EricKhuu TamdanBlock NatalieTalebian AsgharAhmed Mahmoud SalamaGedara Mahesh UdamulleOrtiz MichaelHenkemeyer Mark