Ask about this productRelated genes to: ApoM antibody
- Gene:
- APOM NIH gene
- Name:
- apolipoprotein M
- Previous symbol:
- -
- Synonyms:
- ApoM, G3a, NG20
- Chromosome:
- 6p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-02
- Date modifiied:
- 2016-10-05
Related products to: ApoM antibody
Related articles to: ApoM antibody
- Cirrhosis and hepatocellular carcinoma are severe major adverse liver outcomes (MALOs) of metabolic dysfunction-associated steatotic liver disease (MASLD), yet the relationship between proteomics and MALOs remains unclear. This study aimed to identify plasma proteomic features associated with MALOs and evaluate the potential of proteomics to enhance the prediction of MALOs risks in individuals with MASLD. - Source: PubMed
Publication date: 2026/05/10
Yu HanchengHuang YumeiWang JingyaoZhang JijuanYang LingGeng TingtingLiu GangPan AnLiao Yunfei - Heavy metal exposure is a major public health concern, yet the molecular mechanisms linking environmental toxicants to disease remain poorly understood. We applied an integrative proteomic approach to investigate the biological effects of chronic exposure in environmentally vulnerable populations from the FROM cohort. Across three exposure-control designs, we identified 11, 20, and 54 heavy metal exposure-related proteins, which were predominantly enriched in complement activation, lipid metabolism, and oxidative stress pathways. Using a meet-in-the-middle analysis, we identified 40 proteins and 14 clinical indicators involved in statistically supported exposure-protein-clinical indicator relationships. We then applied Mendelian randomization leveraging protein quantitative trait loci (pQTL) from the FROM cohort and GWAS summary statistics from East Asian populations (KoGES, BBJ) to evaluate putative causality linking proteins, clinical indicators, and environmental diseases. Among the prominent findings, apolipoprotein M (APOM) was associated with serum albumin (β [95% CI] = -0.013 [-0.022, -0.003]; P = 7.57 × 10) and cirrhosis (OR [95% CI] = 1.093 [1.036, 1.153]; P = 1.22 × 10), with serum albumin partially mediating 8.49% of the total effect. This study provides insight into how chronic exposure to heavy metals perturbs molecular pathways involved in disease development, offering a deeper understanding of environmentally driven pathophysiology. - Source: PubMed
Publication date: 2026/05/02
Heo MinMun SoraKim Nam-EunShin HyeongyuDo Ah RaKim JeeyoungKwon Jung-YeonSeo SujinHan HyeinCho Yong MinHong Young-SeoubKang Hee-GyooKim Woo JinWon Sungho - Apolipoprotein M (apoM) is a biologically important protein that facilitates the mobilization and transport of cholesterol and other bioactive molecules in circulation. This study aims to explore the association between plasma apolipoprotein M (apoM) levels and diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM). This cross-sectional study included 339 patients with T2DM. Patients with diabetic retinopathy exhibited greater median plasma apoM levels than those without diabetic retinopathy (26.05 [21.09-30.37] mg/L vs. 21.47 [18.00-26.38] mg/L; < 0.001). In logistic regression models, plasma apoM levels were significantly associated with diabetic retinopathy (odds ratio [OR] per standard deviation increase in log-transformed levels, 1.49; 95% confidence interval [CI], 1.05-2.119; = 0.027) after adjusting for the confounders including age, hypertension, diabetes duration, and HbA. The area under the receiver operating characteristic curve was 0.657 (95% CI: 0.594-0.721), with internal bootstrap validation yielding a stable optimism-corrected area under the curve of 0.658. Our exploratory findings suggest a significant positive association between plasma apoM levels and diabetic retinopathy in patients with T2DM. - Source: PubMed
Publication date: 2026/04/13
Chung Jin OokPark Seon-YoungChung Dong JinChung Min Young - Discovery of autoantibodies in steroid-sensitive nephrotic syndrome (SSNS) has transformed our understanding of SSNS as an immune-mediated disease; however, mechanisms underlying autoantibody production are unknown. Current treatments for SSNS are non-targeted and cause serious adverse effects. We sought to identify circulating proteins with a causal relationship to SSNS, which likely reflect underlying immune derangements, using an unbiased two-sample Mendelian randomization (MR) and colocalization approach to inform novel drug targets for disease. - Source: PubMed
Publication date: 2026/04/10
Heydari DanielLanglois SheldonNorouzi MahboobehMyette Robert LSamuel SusanZhou SiruiTakano TomokoButler-Laporte GuillaumeDownie Mallory L - Retinopathy of prematurity (ROP) is a neurovascular retinal disease affecting extremely preterm infants (<28 weeks' gestational age), and links between early lipid metabolism and ROP are unclear. We investigated whether the lipid mediator sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (ApoM) are associated with ROP and parenteral nutrition in preterm infants. In this multicenter cohort, extremely preterm infants were grouped by ROP outcome: no ROP (n = 72) or any ROP (n = 105). Serum was collected at birth and longitudinally to postnatal day 100. S1P was quantified by LC-MS/MS and ApoM by proximity extension assay. Associations between first month mean parenteral fluid intake, S1P, ApoM, and ROP were analyzed using logistic regression; log-normal linear regression was applied to continuous outcomes, adjusting for gestational age and LCPUFA supplementation. Results showed that serum S1P and ApoM were positively correlated (r = 0.53, 95% confidence interval [CI] = 0.50-0.56). Higher first-month parenteral fluid intake was associated with lower S1P and ApoM (per 50 ml/kg/day increase, geometric mean ratio = 0.84, 95% CI = 0.79-0.88 for S1P; 0.97, 95% CI = 0.96-0.98 for ApoM; both P < 0.001). Higher mean S1P in the first month was associated with reduced odds of any ROP (per 0.1 μmol/l increase, adjusted odds ratio = 0.84; 95% CI = 0.71-0.99; P = 0.037). Mean ApoM was associated with ROP only in unadjusted analyses. In conclusion, low S1P and ApoM levels were linked to high parenteral fluid exposure and ROP development, suggesting that infants with high parenteral nutrition requirements may be particularly vulnerable to S1P-ApoM depletion, supporting this pathway as a potential therapeutic target. - Source: PubMed
Publication date: 2026/03/27
Nilsson Anders KSjöbom UlrikaPanwar Mohit BHellqvist ToveFu ZhongjieAndersson Mats XPivodic AldinaSmith Lois E HLey DavidHellström Ann