Ask about this productRelated genes to: ApoM antibody
- Gene:
- APOM NIH gene
- Name:
- apolipoprotein M
- Previous symbol:
- -
- Synonyms:
- ApoM, G3a, NG20
- Chromosome:
- 6p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-02
- Date modifiied:
- 2016-10-05
Related products to: ApoM antibody
Related articles to: ApoM antibody
- Discovery of autoantibodies in steroid-sensitive nephrotic syndrome (SSNS) has transformed our understanding of SSNS as an immune-mediated disease; however, mechanisms underlying autoantibody production are unknown. Current treatments for SSNS are non-targeted and cause serious adverse effects. We sought to identify circulating proteins with a causal relationship to SSNS, which likely reflect underlying immune derangements, using an unbiased two-sample Mendelian randomization (MR) and colocalization approach to inform novel drug targets for disease. - Source: PubMed
Publication date: 2026/04/10
Heydari DanielLanglois SheldonNorouzi MahboobehMyette Robert LSamuel SusanZhou SiruiTakano TomokoButler-Laporte GuillaumeDownie Mallory L - Retinopathy of prematurity (ROP) is a neurovascular retinal disease affecting extremely preterm infants (<28 weeks' gestational age), and links between early lipid metabolism and ROP are unclear. We investigated whether the lipid mediator sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (ApoM) are associated with ROP and parenteral nutrition in preterm infants. In this multicenter cohort, extremely preterm infants were grouped by ROP outcome: no ROP (n=72) or any ROP (n=105). Serum was collected at birth and longitudinally to postnatal day 100. S1P was quantified by LC-MS/MS and ApoM by proximity extension assay. Associations between first month mean parenteral fluid intake, S1P, ApoM, and ROP were analyzed using logistic regression; log-normal linear regression was applied to continuous outcomes, adjusting for gestational age and LCPUFA supplementation. Results showed that serum S1P and ApoM were positively correlated (r=0.53, 95% CI 0.50-0.56). Higher first-month parenteral fluid intake was associated with lower S1P and ApoM (per 50 mL/kg/day, geometric mean ratio [GMR] 0.84, 95% CI 0.79-0.88 for S1P; 0.97, 95% CI 0.96-0.98 for ApoM; both p<0.001). Higher mean S1P in the first month was associated with reduced odds of any ROP (per 0.1 μmol/L, adjusted odds ratio 0.84, 95% CI 0.71-0.99, p=0.037). Mean ApoM was associated with ROP only in unadjusted analyses. In conclusion, low S1P and ApoM levels were linked to high parenteral fluid exposure and ROP development, suggesting that infants with high parenteral nutrition requirements may be particularly vulnerable to S1P/ApoM depletion, supporting this pathway as a potential therapeutic target. - Source: PubMed
Publication date: 2026/03/27
Nilsson Anders KSjöbom UlrikaPanwar Mohit BHellqvist ToveFu ZhongjieAndersson Mats XPivodic AldinaSmith Lois E HLey DavidHellström Ann - Green manure-crop rotation systems are effective management practices for maintaining soil health and enhancing crop yield. However, the influence of various green manure-millet rotation systems on soil properties, fungal community structure, and millet yield in the North China Plain remains undetermined. In this study, three types of green manures with foxtail millet rotation experiment were conducted. The physico-lchemica indexes, millet yield and soil fungal community characteristic were detected. Our findings suggest that three green manure-millet rotation systems increased millet yield compared to millet-winter fallow (Si-Le). Among them, the Triticale-millet rotation (Si-Ts) showed the highest yield increase, with a rise of 46.16% in 2021 and 85.7% in 2022. In 2021, compared with Si-Le, the organic matter (OM) in Si-Ts increased by 17.86%, and the available phosphorus (AP) rose by 113.82%. In 2022, in contrast to Si-Le, the alkali-hydrolyzed nitrogen (AHN) in Si-Ts increased by 17.68%, the available phosphorus (AP) by 37.56%, and the available potassium (AK) by 12.56%. Additionally, Si-Ts exhibited the highest diversity of soil fungi and the greatest relative abundance of beneficial genera from the dominant phylum Ascomycota and Mortierellomycota. Moreover, Green manure rotations (particularly Si-Ts) alleviate these constraints by simultaneously augmenting microbial diversity (driven by OM/AK/AHN) and crop yield (driven by AP/OM). Overall, the Triticale-millet rotation is a feasible practice for improving soil conditions, maintaining soil microbial balance, and ensuring high yields of millet. Our findings offer theoretical support for green manure-crop rotation in influencing the soil environment and the sustainable development of the millet industry in the North China Plain. - Source: PubMed
Publication date: 2026/03/11
Yu GuohongHan YaLiu JingqiangZhang YingyingHao HongboLi Mingzhe - Apolipoprotein M (apoM) is a subclass of apolipoproteins primarily found in high-density lipoprotein (HDL), it was mainly expressed and secreted in the liver and kidneys. ApoM functions as the carrier of sphingosine-1-phosphate (S1P) to form apoM-S1P complex, further mediating various physiological and pathological processes in the body. Most research has focused on cardiovascular diseases, such as anti-atherosclerosis, with very few studies in the field of nephrology. In recent years, scholars have found that it plays a crucial role in kidney disease. Thereby, this review would summarize the potential roles of apoM and the apoM-S1P axis in various kidney diseases, including chronic kidney disease, diabetic nephropathy, acute kidney injury, glomerular diseases, and renal clear cell carcinoma, providing new insights for the diagnosis and treatment of kidney diseases. - Source: PubMed
Publication date: 2026/03/25
Tao JingjinTan YuanYang ShuoZhang QianLi ZhongxinLiu QiWang HeCui Liyan - Diabetic nephropathy (DN), a predominant cause of end-stage renal disease (ESRD), is primarily driven bfigolic disturbances and mitochondrial dysfunction. Apolipoprotein M (ApoM), a protein associated with high-density lipoprotein (HDL), is notably downregulated in DN and is correlated with a decline in renal function. Recent studies have identified a protective bidirectional axis between ApoM and mitophagy, the selective autophagy of mitochondria. ApoM, chiefly through its role as a carrier for sphingosine-1-phosphate (S1P), enhances mitophagy by activating the silent information regulator 1 (SIRT1) and parkin induced kinase 1 (PINK1)/Parkin pathways, thereby improving mitochondrial quality control. Conversely, mitophagy facilitates ApoM synthesis by supplying sufficient adenosine triphosphate (ATP) for its production and the assembly of HDL. In the context of DN, hyperglycemia disrupts this reciprocal relationship, leading to a detrimental cycle of impaired mitophagy and reduced ApoM, which exacerbates renal injury. Targeting the ApoM-mitophagy axis through ApoM enhancement or mitophagy activation emerges as a promising therapeutic approach for personalized renal protection in DN. This review synthesizes the mechanistic interplay between lipid metabolism and mitochondrial quality control, emphasizing its translational potential and the necessity for further investigation. - Source: PubMed
Chen TianleiYang Min