Ask about this productRelated genes to: PEG10 antibody
- Gene:
- PEG10 NIH gene
- Name:
- paternally expressed 10
- Previous symbol:
- -
- Synonyms:
- KIAA1051, HB-1, MEF3L, RGAG3, Mar2, Mart2, SIRH1, RTL2
- Chromosome:
- 7q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2019-04-23
Related products to: PEG10 antibody
Related articles to: PEG10 antibody
- CRISPR-Cas9 nucleases are widely used to introduce targeted DNA double-strand breaks (DSBs) for genome engineering, but the long-term impact of these lesions on local epigenetic information remains poorly characterized. In a companion research article, we used Cas9-assisted targeted nanopore sequencing (CTS) to reveal that CRISPR-Cas9-induced DSBs can disrupt local epigenetic maintenance across multiple genomic contexts and cell systems. Here, we present a structured description of the raw and minimally processed datasets underlying the study. These datasets provide base-resolution measurements of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) at the differentially methylated regions (DMRs) of several imprinted loci, two heterochromatic regions, a cancer-associated promoter epimutation region, and the SNRPN DMR at early/late passages of a clonal line. They enable re-analysis and methodological benchmarking of DSB-associated epigenetic instability. - Source: PubMed
Publication date: 2026/03/10
Zhang YingziWang MenggeBi ChongweiLi Mo - Upper-tract urothelial carcinomas (UTUCs) are highly aggressive malignancies with a poor prognosis, necessitating the development of new therapeutic targets and biomarkers. functions as a transcription factor and plays an important role in the development and progression of cancer. However, no studies have examined the role of PEG10 in UTUC. - Source: PubMed
Okazaki MaiSekino YoheiHayashi TetsutaroKobayashi G ONakahara HikaruTasaka RyoKohada YukiTakemoto KenshiroNaito MikiMiyamoto ShunsukeKobatake KoheiKitano HiroyukiGoto KeisukeGoriki AkihiroHieda KeisukeNiitsu HiroakiHinoi TakaoHinata Nobuyuki - Selective serotonin reuptake inhibitors (SSRIs) are a recommended first line medication for the treatment of major depressive disorder, due to higher tolerability and lower risk of adverse effects than other antidepressants. The mechanisms by which SSRIs reduce depressive symptoms are not well understood, but are hypothesised to include direct effects on serotonin signalling and synaptic remodelling, and indirect effects on inflammation. Indirect or off-target effects may be detectable in blood and can be investigated using methylome- and transcriptome-wide approaches. - Source: PubMed
Publication date: 2026/02/25
Barker Lauren FMcRae Allan FYuen Hok PanHenders Anjali KWallace Leanne MLin TianDavyson EllaPhassouliotis ChristinaSpark JessicaKerr MelissaStreet RebekahByrne Enda MAmminger G PaulNelson BarnabyWray Naomi RMcGorry Patrick D - Despite recent improvements in diagnostic and therapeutic strategies, gastric cancer (GC) continues to be a major contributor to global cancer fatalities, resulting in suboptimal patient prognosis overall. Cuproptosis, defined as a regulated death mode initiated by intracellular copper overload, has not been comprehensively examined in the context of the tumor immune microenvironment or its prognostic relevance in stomach adenocarcinoma. - Source: PubMed
Publication date: 2026/02/09
Wang ZheMan YuxinYue BingtongLiu MinZhang JiayiWang FengXin Dao - The syncytial variant of nodular sclerosis classical Hodgkin lymphoma (SV-NSCHL) is associated with inferior outcomes. However, the complexity of tumor microenvironment (TME) in SV-NSCHL is poorly understood. Therefore, we aimed to depict and compare the TME among SV-NSCHL and common nodular sclerosis classical Hodgkin lymphoma (cNSCHL). Using Xenium In Situ spatial transcriptomics on 20 regions of interest from 10 specimens (4 cNSCHL, 4 SV-NSCHL, and 2 reactive lymph nodes), we profiled 317,762 cells to map tumor intrinsic characteristics and spatially resolved immune ecosystems. The paternally expressed gene (PEG10) was among the top unregulated genes of Hodgkin and Reed-Sternberg (HRS) cells in SV-NSCHL. Immunohistochemistry (IHC) analysis in an independent cohort (n = 121) confirmed significantly higher PEG10 protein expression in HRS cells from SV-NSCHL and association with proliferation hallmarks. Patients with high PEG10 expression in NSCHL exhibited inferior progression-free survival (PFS), and multivariate analysis identified PEG10 as an independent prognostic factor. Besides, SV-NSCHL demonstrated a distinctly immunosuppressive microenvironment characterized by depletion and functional dampening of CD8 T cells, expansion and higher immunosuppression scores of regulatory T cells (Tregs), altered B cell dynamics, and enrichment of M2-like macrophages with reduced phagocytosis and antigen presentation. Furthermore, although overall ligand-receptor crosstalk was attenuated in SV-NSCHL, specific inhibitory ligand-receptor interactions were preserved and upregulated between HRS cells and Tregs. Collectively, our study provided the first comprehensive spatial atlas of SV-NSCHL. It implicated PEG10 as a candidate contributor to HRS cell proliferation and identified actionable immune evasion signatures, offering a roadmap for targeted therapeutic interventions. - Source: PubMed
Publication date: 2026/02/13
Xiao XiaoyueDong JiyanSun XujieJiang KangWang LongNong LinXue XueminFeng Xiaoli