Ask about this productRelated genes to: EPHB4 antibody
- Gene:
- EPHB4 NIH gene
- Name:
- EPH receptor B4
- Previous symbol:
- HTK
- Synonyms:
- Tyro11
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-15
- Date modifiied:
- 2016-10-05
Related products to: EPHB4 antibody
Related articles to: EPHB4 antibody
- Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon from tobacco smoke, exhaust, and pollutants, is linked to bladder cancer (BLCA). We systematically analyzed GEO datasets to identify BaP-related differentially expressed genes (DEBRGs). By integrating network toxicology, machine learning, molecular docking, molecular dynamics, and single-cell transcriptomics, we identified 19 significant genes, among which 7 key DEBRGs were prioritized (GSK3B, SKP2, AURKB, EPHB4, KIT, NR3C2, and CA2) in BaP-mediated BLCA. SHAP analysis highlighted GSK3B and SKP2 as important genes contributing to the predictive model. Single-cell data revealed their cell-type specific expression in the tumor microenvironment. Molecular simulations detailed interactions between BaP and target proteins. This study identified critical genes in BaP-induced bladder carcinogenesis, offering insights into underlying molecular mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2026/05/21
Zhao XinzhaoQin RuizeShen ChengquanHu DingLi ChengLiu ChangxueGe HuaixiWang Yonghua - Mild hypothermia (MH) has been reported to ameliorate cerebral damage and neurofunctional deficits in ischemic stroke, but its molecular mechanisms remain unclear. This study focuses on exploring the neuroprotective regulatory mechanisms mediated by MH in ischemic stroke. - Source: PubMed
Publication date: 2026/05/20
Feng GanghuaHu YabinLi QiuliWu JibaoLei YuanbiaoWang HaoYao Xiaoxi - Extracranial arteriovenous malformation (AVM) is a rare and debilitating condition with significant morbidity. Clinical trial evidence for targeted therapies remains limited. We evaluated the efficacy and safety of luvometinib, a MEK1/2 inhibitor, in adults with complicated AVM that were inoperable, unsuitable for intervention, relapsed after surgery, or failed previous treatment. - Source: PubMed
Publication date: 2026/05/13
Hua ChenWu ZhuliWang XingliLiu HuilongLi BenZheng YangLin Xiaoxi - Behçet disease (BD) is an inflammatory disorder with significant ocular involvement. Angiopoietins regulate vascular stability, while EphrinB2/EphB4 interactions are essential for retinal neovascularization and endothelial behavior. Endocan, a marker of endothelial activation, contributes to inflammatory processes by mediating leukocyte migration. This cross-sectional study investigates the role of angiopoietins, EphrinB2/EphB4 signaling, and endocan in the development of active uveitis in BD patients. We recruited 29 BD patients with active eye involvement (group 1), 31 BD patients without eye involvement (group 2), and 30 healthy controls (group 3). Serum tyrosine protein kinase receptor (Tie-2), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), EphrinB2, EphB4, and endocan levels were determined by the enzyme-linked immunosorbent assay method. A statistically significant difference was found between the Ang-1, Ang-2, Tie-2, EphrinB2, EphB4, and endocan levels of the 3 different groups in the study (P < .05). Between the patients with panuveitis and patients with only posterior or anterior uveitis, serum Ang-1 (P < .001), Tie-2 (P < .001), EphrinB2 (P < .001), EphB4 (P = .001), and endocan (P = .002) levels had statistically significant differences. The highest and significant correlation was found between EphrinB2 and EphB4 (r = 0.931, P < .001). This was followed by a high level of significant correlation between Ang-1 and Ang-2 (r = -0.845, P < .001). In the group with active uveitis, EphB4 (r = -0.774), Ang-2 (r = -0.763), and Tie-2 (r = -0.701) were negatively and highly significantly correlated with best corrected visual acuity (P < .001). Ang-1, Ang-2, Tie-2, EphrinB2, EphB4, and endocan regulate vascular stability, retinal neovascularization, and inflammation, potentially contributing to BD-associated uveitis. These findings could have important implications for the diagnosis and management of ocular involvement of BD. - Source: PubMed
Gökçek Barutcigil BetülÇinici EmineLaloglu Esra - Ovarian cancer remains challenging to treat because of late diagnosis, heterogeneity, and poor response to existing therapies. Here, we present a streamlined and scalable extracellular vesicle (EV) engineering approach that enables efficient cargo packaging and enhances targeted cargo delivery to ovarian tumors in vivo. Systematic comparison of vesicle-anchoring domains identifies an optimized scaffold for loading bioluminescent cargo into EVs. We characterized EV production from five cell lines commonly used for biopharmaceutical manufacturing and selected and stably engineered ExpiCHO cells as a robust, large-scale source of engineered EVs (eEVs). To achieve molecular targeting, the transmembrane scaffold Δ688 PTGFRN is modified to display tissue-targeting ligand Ephrin-B2 (EB2) on the EV surface, exploiting its high-affinity interaction with the Eph receptor B4 (EphB4), which is overexpressed in advanced ovarian carcinoma. Following systemic administration, these eEVs carrying bioluminescent cargo preferentially accumulate in EphB4-positive cells in vivo and permit non-invasive, spatiotemporal tracking via cargo-mediated bioluminescence resonance energy transfer. In patient-derived xenograft models with differential EphB4 expression, Ephrin-B2-displaying eEVs show selective localization to EphB4-positive tumors and report intratumoral cargo distribution. This work establishes a translational strategy for large-scale eEV production, advancing EV-based delivery platforms for precision targeting of EphB4-expressing ovarian cancer. - Source: PubMed
Publication date: 2026/04/23
Godbole NiharLai AndrewQuinn AlexanderGillard MarianneGuanzon DominicScholz-Romero KatherinSalas-Burgos AlexisDapremont Bastián LilloLourie RohanChetty NavenLobb RichardBeecher KateReed Amy E McCartFerguson KaltinSun BiaoHe YaowuHooper John DSalomon Carlos