Ask about this productRelated genes to: EPHA7 antibody
- Gene:
- EPHA7 NIH gene
- Name:
- EPH receptor A7
- Previous symbol:
- -
- Synonyms:
- Hek11
- Chromosome:
- 6q16.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-10
- Date modifiied:
- 2016-10-05
Related products to: EPHA7 antibody
Related articles to: EPHA7 antibody
- - Source: PubMed
Publication date: 2026/04/22
Wang QihangGu TeLing LiliZhang LiqinCao Bo - Pediatric acute myeloid leukemia (AML) is a biologically distinct and aggressive malignancy with limited effective therapies. While emerging targeted agents, including menin, FLT3, and PRMT5 inhibitors, show promise, the transcriptomic effects and the role of extracellular matrix (ECM) regulators, such as nidogen-1 (NID1), in modulating therapeutic responses remain unclear. - Source: PubMed
Publication date: 2026/02/21
Daniel Muteb MuyeyAndwey Gradel Holel - The Median Raphe (MR) provides a major, mainly serotonergic, input to the hippocampus, particularly influencing the dentate gyrus (DG), but its specific role remains unclear. Here, focusing on the dorsal DG, we investigated its contribution to anxiety-like behavior and learning under stress, using a pathway-specific chemogenetic approach in male Sprague-Dawley rats. Retrograde Cre-expressing AAV was injected into the dorsal DG, and Cre-dependent excitatory (hM3Dq) or inhibitory (hM4Di) DREADDs were expressed in MR neurons. Behavioral assessments included the Open Field (OF), Elevated Plus Maze (EPM), and an extended Two-Way Shuttle Avoidance task (eTWSA). MR-dorsal DG pathway activation had no significant impact, but its inhibition decreased anxiety-like behavior in the EPM and improved eTWSA performance, particularly in behaviorally “diverged” animals. Knocked down in the dorsal DG EphA7, a molecule involved in basket cell synapse stabilization on DG granule cells, prevented the anxiolytic effects and behavioral divergence induced by MR-dorsal DG inhibition, but did not prevent improved eTWSA performance. These findings suggest a dissociation between mechanisms of emotional regulation and stress-related learning mechanisms within the dorsal DG, with the MR input to DG basket interneurons modulating anxiety but not learning flexibility. The results highlight a subregion- and pathway-specific role of the MR-hippocampal input in modulating behavior. - Source: PubMed
Publication date: 2026/02/02
Quan JKriebel MAnunu RSnippe-Strauss MVolkmer HRichter-Levin Gal - Uveal melanoma (UVM) is a rare cancer that represents the second most common melanoma (after the cutaneous) and the most common primary intraocular malignancy in adults. Despite recent advances in the understanding of UVM pathogenesis, its prognosis remains unchanged, with half of patients dying because of liver metastasis. Erythropoietin-producing human hepatocellular receptors (EPHs) constitute the largest known family of tyrosine receptors, and, along with their ligands, EFNs, regulate key physiological processes and are implicated in cancer pathogenesis. In this study, we used open-access web bioinformatics platforms to explore and analyze big datasets provided by The Cancer Genome Atlas (TCGA) UVM cohort of patients. We profiled the genomic alterations present in a subset of UVM patients, highlighting a likely pathogenic deep deletion of . Survival analysis showed that overexpression levels of , , , , and are significantly associated with poor overall survival. Additionally, high expression levels of , , , , , , and correlate with reduced progression-free interval and disease-free survival. Finally, we identified the EPHs (, , , and ) and EFNs (, , , and ) that are significantly overexpressed in the aggressive epithelioid histological subtype and revealed that the majority of EPHs/EFNs are overexpressed in metastatic disease. In conclusion, our results highlight that a subset of EPHs and EFNs may be associated with worse clinical outcomes (, , , , , , and ), and an aggressive histological subtype (, , , , , , , and ). The potential correlation of these genes with clinicopathological parameters of UVM need to be evaluated and validated with bioinformatic and experimental approaches in well-characterized cohorts of UVM patients. - Source: PubMed
Publication date: 2025/12/31
Mandrakis GeorgiosFlessa Christina-MariaKeratsa PanoraiaZaravinos ApostolosTheocharis StamatiosSykaras Alexandros G - We report a case of a patient with a CD30-positive lymphoproliferative disorder (CD30+LPD) comprised of gamma-delta T-cells. After 4 years of clinical follow-up with conservative management and multiple biopsies, the indolent course and histopathologic findings best support a diagnosis of primary cutaneous anaplastic large cell lymphoma (pcALCL) with concomitant lymphomatoid papulosis (LyP)-type lesions. Sequencing revealed missense mutations involving ADGRA2, EPHA7, ERBB2, LRP1B, NOD1, RAF1, RICTOR, and WDR90. No fusions were identified. Review of the copy-number profile revealed aneuploidy, which included gain of 1q, loss of 16q, and loss of 19p13.3. Altogether, these findings were insufficient to establish a diagnosis of pcGDTCL. We review the clinical, histopathologic, and molecular sequencing data pertaining to our rare patient as well as the recent literature on indolent CD30+LPD with gamma-delta T-cells. - Source: PubMed
Publication date: 2025/12/12
Weiner DavidCarter Joi BLansigan FrederickLeBlanc Robert E