Ask about this productRelated genes to: NCOA3 antibody
- Gene:
- NCOA3 NIH gene
- Name:
- nuclear receptor coactivator 3
- Previous symbol:
- -
- Synonyms:
- RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-17
- Date modifiied:
- 2016-10-05
Related products to: NCOA3 antibody
Related articles to: NCOA3 antibody
- MicroRNA and mRNA profiling of T cells from Acquired Aplastic Anaemia (AA) patients using both in-silico and in-vitro methods identified molecular changes, including altered immune-regulatory gene expression, linked to T-cell dysregulation and AA pathobiology. - Source: PubMed
Publication date: 2026/04/16
Rai BhuvneshSabereen GhazalaSaxena PragatiSrivastava JyotikaGupta RuchiChaturvedi Chandra Prakash - Intrinsically disordered proteins (IDPs) play essential roles in cellular signaling and regulation, often relying on transient structural elements to mediate interactions. NMR chemical shifts are widely used to detect secondary structures in IDPs, but complementary methods are needed to validate and refine these measurements. Hydrogen exchange is a powerful probe of local structure and dynamics in folded proteins, yet its accuracy for detecting small differences in transient helicity in IDPs remains understudied. Here, we systematically evaluate hydrogen exchange measured by NMR and MS (HDX-MS) in four variants of the activator for thyroid hormone and retinoid receptors (ACTR) activation domain that differ in helical propensity. Using NMR-based exchange rates, we introduce pseudo-protection factors referenced to the wild-type protein, enabling a robust comparison among variants without relying on "intrinsic" peptide-based chemical exchange rates. These pseudo-protection factors correlate strongly with helicity derived from chemical shifts, demonstrating that hydrogen exchange can resolve subtle structural differences in highly dynamic regions and vice versa. Our findings establish hydrogen exchange as a sensitive and reproducible method for characterizing transient structure in IDPs, complementing NMR chemical shift analysis. - Source: PubMed
Publication date: 2026/04/06
Cuciurean I SiminaParsbæk Christian BuchRand Kasper DMulder Frans A ATeilum Kaare - Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are leading causes of cirrhosis and hepatocellular carcinoma. Defects in autophagy contribute to the development of MASLD, however, the role of the Unc-51-like autophagy-activating kinase 1 (ULK1) in the pathophysiology of MASLD remains unclear. Herein, we show that ULK1, a serine/threonine kinase and core autophagy protein, is significantly repressed in human MASH livers, and that hepatocyte-specific loss of ULK1, unexpectedly, promotes hepatic steatosis and progression to liver fibrosis, without affecting basal autophagy flux. Phospho-proteomics identified the transcriptional coactivator NCOA3 as a downstream phospho-target of ULK1. Mechanistically, ULK1 phosphorylates NCOA3 to repress its transcriptional activity and restrain the CREB/CBP-mediated de novo lipogenic program. Accordingly, a phosphorylation-deficient NCOA3 mutant drives CREB/CBP-mediated lipogenesis, whereas genetic or pharmacological NCOA3 inhibition prevents steatosis, hepatic inflammation, and profibrotic signaling. Hence, ULK1-mediated NCOA3 phosphorylation is a fundamental and druggable checkpoint against the entire MASLD spectrum. - Source: PubMed
Publication date: 2026/04/02
Koo Young DoCastillo Romilia TatianaSukumaran Nair AshaGarneau MichaelGochee ChadCampbell Zachary VVakil Tashya ShreyasHa JuaMarti AlexSoto JamieDas DebajyotiMartinez-Lopez NuriaSharma ShipraDelgado YenniferPhung CallieAshley Immy AKapelczak Edmund DJacobo RashelWeatherford Eric TDai Dao-FuBenhammou Jihane NMarshall Andrea GHinton AntentorYang LingPereira Renata OTeSlaa TaraBouhaddou MehdiSingh RajatAbel E Dale - In dairy sheep, mammary morphology-related phenotypes are crucial functional traits due to their connection to machine milking aptitude, udder health, particularly mastitis, and animal welfare. This study aimed to dissect the genetic architecture underlying 5 mammary morphology traits (Udder depth, Udder attachment, Teat placement, Teat size, and Udder shape) in Churra dairy sheep by using data generated with the Illumina OvineSNP50 BeadChip. The analyzed population, part of the Churra Dairy Selection Nucleus (ANCHE), comprised 1,680 ewes distributed across 16 half-sib families. Genome scans using linkage analysis and a GWAS detected 5 genome-wide significant QTL regions. Comparison with previously reported sheep QTL revealed no direct overlap; however, several of the identified regions coincided with QTL reported in cattle for mammary morphology and mastitis resistance traits, suggesting the possibility of conserved genetic mechanisms underlying these traits across ruminant species and further supporting the relevance and validity of the genomic regions detected in this study. Interestingly, the genome-wide significant QTL region detected on OAR13 for Teat placement showed overlapping with chromosome-wide effects on Udder shape, suggesting for this region a potential pleiotropy effect or the presence of closely linked variants affecting multiple udder traits. To further explore the genome-wide significant regions identified in this study, all genes within each region were annotated. Among the 84 annotated genes, 3 of them, NCOA3, ASS1, and TMEFF2, directly overlapped with a previously defined reference gene list for udder traits and were therefore considered direct functional candidate genes. These genes were associated with epithelial branching, extracellular matrix regulation, cytoskeletal dynamics, and signaling pathways. For the remaining annotated genes in the target regions, a prioritization analysis was performed to identify additional potential candidate genes that may be relevant to the traits under study. The results reported here offer a valuable insight into the genetic basis of udder morphology traits in dairy sheep and are a first step into the identification of genetic markers that could improve the efficiency of future genomic selection programs in dairy sheep. - Source: PubMed
Publication date: 2026/03/02
Vrcan MSuárez-Vega AMarina HDzidic AArranz J JGutiérrez-Gil B - Steroid receptor coactivator 3 (SRC-3) is highly expressed in regulatory T cells (Tregs) and is important for their immunosuppressive activity. Recently, we demonstrated that disrupting SRC-3 expression in Tregs eliminates triple-negative breast cancer (TNBC) and prostate cancer in syngeneic animal models by generating an anti-tumor immune microenvironment without inducing immune-related adverse events (irAEs). Further analysis of these mice revealed that SRC-3 knockout (KO) Tregs infiltrated breast tumors and facilitated the infiltration of CD8, CD4, and natural killer (NK) immune cells into the tumor microenvironment (TME). Given the anti-tumor effects of SRC-3KO Tregs in two different solid cancers, we sought to extend our studies to additional cancer types. Here, we showed that SRC-3KO Tregs exerted a potent antitumor immunity-like effect, capable of eradicating glioblastoma, melanoma, and lung cancer in their respective syngeneic mouse models by generating an anti-tumor immune environment. These results support the translational development of SRC-3-targeted Treg modulation as a safe and effective immunotherapy platform for treatment-refractory cancers. - Source: PubMed
Publication date: 2026/03/02
Sung NuriKim EunsuGilad YosefPark YuriDean Adam MXia YanXu JianmingDacso Clifford CLonard David MHan Sang Jun