Ask about this productRelated genes to: ETV4 antibody
- Gene:
- ETV4 NIH gene
- Name:
- ETS variant 4
- Previous symbol:
- -
- Synonyms:
- E1A-F, E1AF, PEA3
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-03-27
- Date modifiied:
- 2016-02-25
Related products to: ETV4 antibody
Related articles to: ETV4 antibody
- Ferroptosis can be inhibited by insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) in cancers. ETS variant transcription factor 4 (ETV4) is aberrantly expressed in various cancers. Elevated transcription of guanosine triphosphate cyclohydrolase 1 (GCH1) contributes to tumor malignancy. This study investigated the involvement of IGF2BP3, ETV4, and GCH1 in ferroptosis in gastric cancer (GC). - Source: PubMed
Publication date: 2026/05/01
Li KanWei HuiLi FangZheng YaZhou Yongning - Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally. Ferroptosis, a regulated form of cell death, has emerged as a promising frontier in CRC treatment. The transcriptional regulator ETV4 (ETS variant transcription factor 4) is implicated in CRC pathogenesis. However, its functional role has not been fully elucidated, and its potential to modulate ferroptosis in CRC is entirely unknown. This study aimed to investigate whether ETV4 modulates ferroptosis in CRC by regulating SLC7A11 and to explore the underlying mechanism involved. - Source: PubMed
Publication date: 2026/05/02
Chao ZhouzhouYin JinbaoHuang FengxiaXu JinlianLv YingyanChen JiayaoXu AijingZhu WeiWang Jinxing - Melanoma is an aggressive form of skin cancer with few effective treatments available at advanced stages. E26 transformation-specific translocation variant 4 (ETV4) is implicated in tumor progression in several malignancies. However, its role in melanoma and immune evasion remains poorly defined. The objective of this study was to investigate the expression and function of ETV4 in melanoma. ETV4 expression in melanoma tissues and cells was assessed by bioinformatics, quantitative PCR, Western blotting, and immunohistochemistry. Melanoma cell lines with ETV4 overexpression or knockdown were assessed for colony formation, wound healing, and Transwell migration/invasion. The regulatory relationship between ETV4 and integrin-associated protein (CD47) was investigated via dual-luciferase reporter assays and chromatin immunoprecipitation. Macrophage-mediated phagocytic activity was assessed using flow cytometry. ETV4 was markedly upregulated in melanoma tissues and cells, correlating with poor patient survival. Overexpression of ETV4 facilitates melanoma cell proliferation, migration, and invasion. Mechanistically, ETV4 directly bound to the CD47 promoter, transcriptionally activating its expression. ETV4 overexpression enhanced the phosphorylation of Src homology region 2 domain-containing phosphatase-1 and suppressed macrophage phagocytosis, suggesting activation of the CD47/signal regulatory protein α immune checkpoint pathway. Notably, knockdown of CD47 reversed the immunosuppressive effects induced by ETV4 overexpression, restoring macrophage phagocytic activity. ETV4 promotes melanoma progression and immune evasion by upregulating CD47 and activating the CD47/signal regulatory protein α signaling axis. Targeting the ETV4/CD47 pathway may represent a promising therapeutic option to enhance antitumor immunity in melanoma. - Source: PubMed
Publication date: 2026/04/27
Lu XuetaoChen MengFan HuayuGao ShuangshuangChen Jinguang - Colorectal cancer (CRC) remains a major health threat with poor prognosis in advanced stages. The transcription factor ETV4 (ETS translocation variant 4) has been implicated in various cancers, but its specific role, prognostic value, and mechanisms in CRC, particularly concerning the tumor immune microenvironment, are not fully understood. - Source: PubMed
Publication date: 2026/04/15
Meng RuipengWang ShilongShe ZhanfeiWang HuaimingWu BoQiao YuChen PengyuanNargerel Yang XiaofengWang Liang - CIC::DUX4 sarcoma (CDS) is a rare cutaneous and deep soft tissue tumor in the differential diagnosis of small round blue cell sarcomas. CDS, by definition, is negative for rearrangements in EWSR1, and has been reported to have strong nuclear WT1 expression and ETV4 expression in most published cases so far. We herein report a case of challenging CDS diagnosed by genomic profiling, with weak, focal cytoplasmic WT-1 positivity, positive staining for CD56, CD138 (subset), and CD4 (subset). This case highlights the challenges involved in evaluating cutaneous small round blue cell tumors based on morphology and immunohistochemistry alone, especially in the presence of an atypical immunophenotype. - Source: PubMed
Publication date: 2026/03/31
Jiang JaniceSay BrandonBrown RyanneRieger KerriCharville Gregory WNarala SaisindhuSaleem AtifNovoa Roberto