Ask about this productRelated genes to: ETV4 antibody
- Gene:
- ETV4 NIH gene
- Name:
- ETS variant 4
- Previous symbol:
- -
- Synonyms:
- E1A-F, E1AF, PEA3
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-03-27
- Date modifiied:
- 2016-02-25
Related products to: ETV4 antibody
Related articles to: ETV4 antibody
- Stromal cell states are altered in active Crohn's disease (CD), but their origin and phenotypic stability are unknown. Using single-cell spatial transcriptomics, RNA sequencing and ATAC sequencing of ~2,500,000 cells, we map 18 distinct stromal cell states within their cellular and cytokine signaling environments in human full-thickness CD bowel. Inflammatory fibroblasts (IFs) reside in immune cell-rich mucosal ulcers and are induced through combinatorial cytokine exposure suppressing submucosal universal fibroblast programs. The IF state is stabilized through transcription factor (TF) activity of GLI3, TWIST1, ETV4, PRDM1 and RELB, and does not spontaneously revert; however, histone deacetylase inhibition destabilizes the IF state, preventing IF secretome-induced epithelial transmigration and activation of neutrophils. The IF open chromatin configuration is distinct from that of fibrotic contractile stroma, which populate adjoining immune-depleted submucosal fibrotic niches. These findings show that microenvironments in pathological tissue niches shape open chromatin configuration of stromal states that are amenable to modulation by epigenetic modifiers. - Source: PubMed
Publication date: 2026/08/12
Koplev SimonSharma OsheenWoelfel SimonHuang NiPohin MathildeFeile AdrianWarschinke MariaArtero Mikel RezolaSuthakaran SharujanSarropoulos IoannisPett J PatrickNyman JuliaThomas TomPham DuyLi BinAttar MoustafaPakpoor JuliaMilosevic-Hutton KateEaston AlistairButler MattDunford JamesPhilpott MartinColes MarkBuckley Christopher DDendrou CalliopeShamiyah KhalidKretschmer LorenzDratva LisaIssa FadiHester JoannaRittscher JensWalsh AlissaTravis Simon PProgatzky FränzeUnger Lukas WBignell MarkBaker KatherineGeorge BruceAl-Mossawi HusseinKlenerman PaulMosig Alexander SOppermann UdoTeichmann Sarah APowrie Fiona MFriedrich Matthias - ETV4 (ETS-transformation-specific variant 4) is a member of the ETS transcription factor family that has been extensively studied for its oncogenic functions in cancers. Here, we summarize the role and mechanisms of ETV4 in cancer biology, with a particular focus on colorectal cancer (CRC), as well as its biomarkers and therapeutic potential. As a transcription factor, ETV4 regulates the expression of target genes by recognizing the GGA(A/T) core conserved sequence. It is frequently overexpressed in pan-cancer, where its overexpression associated with poor prognosis. Upon activation by oncogenic signaling pathways (e.g., MAPK, PI3K/Akt, and WNT), ETV4 transcriptionally regulates downstream genes to promote tumor cell proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), chemoresistance, metabolic reprogramming, and immune evasion. It also form a vicious positive feedback loop that continuously activates oncogenic signaling. In CRC, ETV4 is overexpressed, correlating with advanced disease, lymph node metastasis, and poor prognosis. Upon activation by oncogenic signals, ETV4 directly activate target genes (such as matrix metalloproteinases) to mediate adenoma-to-adenocarcinoma progression, proliferation, EMT, ferroptosis, invasion, metastasis, metabolic reprogramming, and tumor microenvironment remodeling in CRC. ETV4 also forms transcriptional complexes with certain epigenetic factors, such as miRNAs and p300. Moreover, ETV4 is a promising biomarker for CRC diagnosis, prognosis, and adenoma-to-adenocarcinoma progression. Targeting ETV4 or its upstream pathways represents a potential therapeutic strategy for CRC. However, there are still many unresolved issues in current research. For example, the role of ETV4 in immune evasion and tumor microenvironment remodeling remains at the descriptive stage, and the specific mechanisms by which it regulates immune cell recruitment have not yet been elucidated. Future efforts include utilizing multi-omics approaches to elucidate the mechanisms by which ETV4 shapes the CRC microenvironment and exploring the application prospects in tumor immunotherapy. - Source: PubMed
Publication date: 2026/07/15
Liu YuanbinWang YiyunHuang MinTian XiaHuang Xiaodong - Matrix metalloproteinase-9 (MMP9) is involved in extracellular matrix remodeling, inflammation, and metastasis, and its overexpression is associated with poor prognosis in lung cancer. However, the systems-level effects of MMP9 inhibition remain incompletely understood. We combined systems biology with experimental validation to characterize MMP9-centered signaling in non-small cell lung cancer (NSCLC) and identify downstream pharmacodynamic biomarkers. Network and pathway analyses revealed extracellular matrix- and inflammation-related interaction modules and prioritized an -associated gene panel. Synthesized compounds were evaluated using purified enzyme assays and A549 NSCLC cells. At 50 μM, compounds M34 and M33 showed the strongest inhibition of MMP9 activity (65.01% and 61.32%, respectively). Seven compounds (M1, M2, M8, M9, M10, M27, and M34) demonstrated antiproliferative activity at 72 h (IC = 40-115 μM), suppressed migration and colony formation, induced apoptosis, and reduced MMP9 protein expression. Quantitative PCR confirmed coordinated downregulation of , , , and , with upregulation of , , , , and . Enrichment analysis linked these changes to inflammatory signaling, immune activation, and extracellular matrix remodeling. These findings establish an experimentally supported eight-gene pharmacodynamic biomarker signature and support biomarker-guided development of MMP9-targeted strategies in NSCLC. - Source: PubMed
Publication date: 2026/07/20
Rashid Zainab AhmedHajjo RimaSabbah Dima ASweidan KamalAlmutairi ShriefaBardaweel Sanaa K - The E26 transformation-specific family of transcription factors regulates the cell cycle and apoptosis that are crucial for carcinogenesis. More specifically, the PEA3 subfamily-comprising ETS variant (ETV) transcription factors ETV1, ETV4, and ETV5-has been implicated in multiple oncogenic signaling pathways and chemotherapy resistance. While cisplatin is still a widely used chemotherapeutic treatment for ovarian cancer, its therapeutic efficacy is sometimes limited by the induction of resistance mechanisms. The present study investigates the potential role of PEA3 subfamily genes in cisplatin resistance in ovarian cancer through comprehensive in silico analyses. - Source: PubMed
Publication date: 2026/04/21
Sökmen Fevzi CoşkunKardana LaikaYilmaz HikmetÖzketen Ahmet ÇağlarKaradağ Gürel AynurAtay ÖzgeKazan Hasan Hüseyin - The cerebral cortex is highly sensitive to oxygen availability and thus serves as an ideal model for studying neural adaptation to hypoxia. Here, we integrated long-read (Oxford Nanopore) and short-read (Illumina) single-cell RNA sequencing to systematically characterize the cellular composition and transcriptional landscape of the cerebral cortex in high-altitude Diqing Tibetan pigs (DT, ~3200 m) and low-altitude Diannan small-ear pigs (DSE, ~500 m). Single-cell analysis identified nine major cortical cell types and revealed pronounced transcriptional divergence between the breeds. In DT, multiple genes associated with high-altitude hypoxia adaptation and energy homeostasis, including NKAIN2, CTNNA3, ZFP36, and HSP40 family members, were significantly upregulated. Functional enrichment highlighted mitochondrial oxidative phosphorylation and energy metabolism pathways, suggesting metabolic reprogramming under chronic hypoxia. Key transcription factors, including SOX17, NKX6-2, ETV4, and SPI1, displayed cell-type-specific activity in Endo, Oligo, and Micro. Cell-cell communication analysis showed DSE with broader intercellular connectivity, whereas DT exhibited more focused and stronger signaling interactions. Integration of long-read sequencing further identified numerous novel, cell-type-specific transcripts, expanding porcine cortical transcriptome annotation. Collectively, these findings provide a comprehensive framework for understanding cellular and molecular adaptations of the cerebral cortex to prolonged high-altitude hypoxia. - Source: PubMed
Publication date: 2026/07/21
Chang YongchengDuan BofangHuo HailongZhang XiaLin WanWen FeidiGuo YimingWu LingxiangZou FengcaiHuo JinlongZhao Guiying