Ask about this productRelated genes to: MAPK11 antibody
- Gene:
- MAPK11 NIH gene
- Name:
- mitogen-activated protein kinase 11
- Previous symbol:
- PRKM11
- Synonyms:
- p38-2, p38Beta, SAPK2
- Chromosome:
- 22q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-28
- Date modifiied:
- 2015-08-25
Related products to: MAPK11 antibody
Related articles to: MAPK11 antibody
- Ulcerative colitis (UC) arises from complex crosstalk between gut microbiota, epithelial barrier integrity, and inflammatory cell death, yet causal mediators along this axis remain poorly defined. We aimed to delineate microbiota-pyroptosis-UC pathways and functionally validate key effectors, with a focus on KLF4. - Source: PubMed
Publication date: 2026/03/16
Zhu WenyaJin XiaoxuGuo XiaofengGao Xin - Human organoids that mirror their corresponding organs in cell-type diversity present an opportunity to perform large-scale screens for compounds that protect disease-affected or damaged healthy cell types. Here, we generated 20,000 human retinal organoids with green fluorescent protein (GFP)-labeled cone photoreceptors. Since degeneration of cones is a leading cause of blindness, we induced cone death and screened 2,707 compounds with known targets for those that saved cones or those that further damaged cones. We identified inhibitors of casein kinase 1 (CK1) that protected cones, heat shock protein 90 (HSP90) inhibitors that saved cones in the short term but damaged them in the longer term, and broad histone deacetylase (HDAC) inhibition by many compounds that significantly damaged cones. Finally, we confirmed the protective effects of identified compounds in a mouse model of photoreceptor degeneration. This work provides a database for cone-damaging compounds and describes compounds and targets that can be starting points to develop neuroprotection for cones in diseases such as macular degeneration. - Source: PubMed
Publication date: 2026/03/30
Spirig Stefan EHerrero-Navarro ÁlvaroUtz LarissaArteaga-Moreta Valeria JRaics ZoltanPosada-Céspedes SusanaChreng StephanieGaluba OlafGaluba IngaClaerr IsabelleRenner SteffenBoldogkoi MiklosMoreno-Juan VerónicaKleindienst P TimoVolak AdriennImbach JannickMalysheva SvitlanaSiwicki Rebecca AHahaut VincentHou YanyanRodrigues Tiago MPicelli SimoneCattaneo MarcoJüttner JosephineCowan Cameron SDuckely MyriamBaeschlin Daniel KRenner MagdalenaUnterreiner VincentRoska Botond - Pulmonary tuberculosis (TB) remains a major global health challenge. The molecular and metabolic responses of monocyte-derived macrophages (MDMs), which are critical for host defense against (Mtb), are not fully characterized. A murine pulmonary TB model was established by intravenous injection of BALB/c mice with the attenuated Mtb strain H37Ra; controls received saline. After 8 weeks, lung MDMs were isolated for integrated transcriptomic and untargeted metabolomic profiling. Transcriptomic analysis identified 3970 differentially expressed genes (DEGs) in infected MDMs, including upregulated , , and and downregulated , , and . Metabolomic profiling revealed 113 differentially accumulated metabolites (DAMs). Taurocholic acid and linoleic acid were identified as potential diagnostic biomarkers, both achieving an area under the curve (AUC) of 1.0 in ROC analysis. Integrated omics analysis showed a positive correlation between linoleic acid levels and the expression of , , and , implicating lipid metabolic pathways in the host response to TB. This multi-omics study delineates key molecular and metabolic alterations in lung MDMs during TB infection. The identified metabolites, taurocholic acid and linoleic acid, show promise as biomarkers, while dysregulated linoleic acid metabolism represents a potential target for novel diagnostic and therapeutic strategies against TB. - Source: PubMed
Publication date: 2026/02/27
Sha YuxiaZhao XiaomanZhu HongyingLi YeShao MeilinDing ShenggangZhou Haoquan - The greater amberjack () is a globally important aquaculture fish species belonging to the family Carangidae. However, current research on the ovarian development and regulation of the greater amberjack is limited, particularly with regard to early ovarian development in artificially bred individuals. Therefore, this study aims to analyze the ovarian transcriptomes at the primary growth stage in one-year-old fish at the chromatin nucleolar stage and two-year-old fish at the perinucleolar stage to suggest how early ovarian development takes place in artificially bred greater amberjacks. To do this, the study constructed ovarian mRNA expression profiles of different stages of artificially bred fish and identified differentially expressed genes (DEGs), Gene Ontology terms, and Kyoto Encyclopedia of Genes and Genomes pathways important for various physiological processes. A functional analysis revealed that the DEGs closely related to ovarian development were involved in cell growth and death (e.g., , , , , , and ), the TGF-beta signaling pathway (e.g., , , , , , and ), steroid hormone biosynthesis (e.g., , , and ), and the endocrine system (e.g., , , , and ). These findings suggest that ovarian development is the result of the coordinated regulation of various genes responsible for various functions. This study provides a theoretical basis for exploring the underlying molecular mechanisms of early ovarian development in artificially bred greater amberjacks. - Source: PubMed
Publication date: 2026/02/25
Deng QiuxiaHuang YangRu XiaoyingLin HaoyiYou XinxinHao RuijuanLi HangHu QinZhang DongyingZhao YanfeiWu JinhuiLi GuangliZhu Chunhua - Glioblastoma (GBM) remains a therapeutic challenge with limited treatment options and poor prognosis. 18β-Glycyrrhetinic acid (GA), a natural metabolite from licorice, has shown anti-tumor potential, but its pharmacological effects in GBM and the underlying mechanisms require systematic investigation. - Source: PubMed
Publication date: 2026/02/17
Luo XuanzhiZeng YuanWang XueLi MujinWang Ya-LeiPeng TiantianMa CuiyanHua Qian