Ask about this productRelated genes to: BCL10 antibody
- Gene:
- BCL10 NIH gene
- Name:
- BCL10 immune signaling adaptor
- Previous symbol:
- -
- Synonyms:
- CARMEN, CIPER, mE10, c-E10, CLAP
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-08
- Date modifiied:
- 2019-04-23
Related products to: BCL10 antibody
Related articles to: BCL10 antibody
- Epstein-Barr virus (EBV) is a human herpesvirus that causes a variety of hematological malignancies, in particular B-, T- and NK-cell lymphomas. Latency proteins of the virus contribute to lymphomagenesis by activating the transcription factor NF-κB, however, the molecular mechanism underlying EBV-driven NF-κB activation remains incompletely understood. Here we show that EBV latent membrane proteins LMP1 and LMP2A or LMP2B synergize to activate the protease MALT1, a key driver of NF-κB-mediated lymphocyte proliferation. EBV-positive B-cell lines co-expressing LMP1 and LMP2 proteins exhibited constitutive MALT1 activity, and treatment with a MALT1 inhibitor or silencing of latent membrane protein-1 (LMP1) or LMP2 impaired MALT1-dependent substrate cleavage. LMP1 physically interacted with the MALT1-binding partner BCL10, while LMP2A and LMP2B interacted with MALT1. LMP1 also colocalized with LMP2 in dotted structures, suggesting that LMP1 and LMP2 synergize via the coordinated formation of LMP-BCL10-MALT1 (LBM) complexes. Finally, MALT1 protease inhibition led to reduced expression of a set of NF-κB-driven genes, and reduced tumor growth in an EBV-positive lymphoma xenograft model. These findings establish a key role for the protease MALT1 in LMP1/2-mediated, NF-κB-driven cellular transformation and provide a rationale for inhibiting MALT1 to treat EBV-positive B-cell lymphomas that co-express LMP1 and LMP2. - Source: PubMed
Publication date: 2026/08/13
Juilland MélanieRomy LaurenceRashid Harun-OrLopes Sara EscudeiroPodavini SilviaVallois DavidLuo ManhuiGonzalez MontserratPandeva KaterinaFrête FrédéricDécaillet Chantalde Leval LaurenceRothenberger SylviaThome Margot - Adult T cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy with poor prognosis. Recurrent genetic alterations in T cell receptor (TCR) signaling components, including , , and , highlight the biological relevance of this pathway in ATL. We focused on mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), a key regulator of TCR signaling that functions through complex formation with CARD11 and BCL10, and developed a potent and selective MALT1 protease inhibitor, CRD-1441551. CRD-1441551 exhibited variable antitumor effects across ATL models both and . Among three ATL cell lines and five patient-derived xenograft models, two demonstrated marked sensitivity, three showed modest responses, and three were unresponsive. Notably, therapeutic responses were more frequently observed in models with constitutive MALT1 activation accompanied by enhanced MALT1-NF-κB signaling. These findings suggest that CRD-1441551 preferentially targets a subset of ATL, in which tumor growth is dependent on the MALT1-driven NF-κB pathway. - Source: PubMed
Publication date: 2026/07/23
Kamiunten AyakoMorishita DaisukeKameda TakuroSugiyama MidoriEbara ShunsukeKogure YasunoriMizutani AkioHirayama TakaharuKawamoto TomohiroOchi YotaroShide KotaroTokuhara HidekazuTanaka ToshioBanno HiroshiArikawa YasuyoshiMaru TakamitsuOki HideyukiYoda AkinoriTahira YukiIkeda RyomaMatsumoto KengoKarasawa MasayoshiAkizuki KeiichiSekine MasaakiShimoda HarukoHidaka TomonoriKubuki YokoYamaguchi HidekiHasegawa HirooImaizumi YoshitakaYasunaga Jun-IchirouMatsuoka MasaoYoshimitsu MakotoIshitsuka KenjiKataoka KeisukeOgawa SeishiShimoda Kazuya - Diabetic retinopathy (DR) reflects retinal microvascular injury and systemic immune-metabolic stress, and most public DR transcriptomic datasets lack paired microbiome/metabolomic profiles. We used gutMGene v2.0 as a curated microbe/metabolite-host gene prior and integrated it with peripheral blood transcriptomics from GSE221521. Candidate genes were refined by weighted gene co-expression network analysis (WGCNA), repeated resampling, cross-dataset assessment, mechanism scoring, peripheral blood mononuclear cell (PBMC) single-cell localization and filamin A ()-centered single-cell gene regulatory network (GRN) virtual knockout. The gutMGene prior contained 238 host genes; 15 DR-associated genes overlapped this prior, and WGCNA retained ten candidate gut microbe and microbial metabolite-related genes (GMMRGs): , , , , , , , , and . Resampling prioritized as the most consistent candidate. Cross-dataset assessment localized the strongest signal to type 2 diabetes (T2D) PBMCs, retinal endothelial cells and advanced proliferative diabetic retinopathy with diabetic macular edema (PDR + DME) retinal tissue, with weaker separation in whole blood, broad retinal tissue and six-donor type 1 diabetes (T1D) PBMCs. virtual knockout predicted cell-context-dependent perturbation of immune-related transcriptional programs, including in DR B cells and in DR monocytes/NK cells. This prior-guided study identifies within a ten-gene GMMRG set as a circulating host-response signal that links curated microbe/metabolite-host records to immune-vascular and cytoskeletal remodeling in DR. - Source: PubMed
Publication date: 2026/07/10
Ma ChuanxueWang YujunLiu Yi - BCL10 is a core CBM (CARD-BCL10-MALT1) complex component required for antigen receptor-mediated NF-κB activation. BCL10 deficiency is an exceptionally rare autosomal recessive combined immunodeficiency, with only six patients reported to date. We aimed to characterize the clinical, immunologic, and molecular features of a novel homozygous BCL10 variant and explore mechanisms associated with its leaky phenotype. - Source: PubMed
Tong LinWei QinglvLi YulinTian ZhiruiDai RongxinGong XiaozhenFeng ZijuanJia YanjunDu HongqiangWu JunfengYang XiAn YunfeiZhao XiaodongZhou Lina - The prognosis for colorectal cancer (CRC) is poor, and the disease is marked by high rates of morbidity and death, highlighting the need for reliable biomarkers. RNA methylation modifications play important roles in cancer biology. However, the integrated role of m6A/m5C/m1A/m7G modifications in CRC has not been fully characterized and requires further investigation. - Source: PubMed
Publication date: 2026/07/08
Chen RuyueYao ZengwuJiang LixinHu Jinchen