Ask about this productRelated genes to: BCL10 antibody
- Gene:
- BCL10 NIH gene
- Name:
- BCL10 immune signaling adaptor
- Previous symbol:
- -
- Synonyms:
- CARMEN, CIPER, mE10, c-E10, CLAP
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-08
- Date modifiied:
- 2019-04-23
Related products to: BCL10 antibody
Related articles to: BCL10 antibody
- Acinar cell carcinoma (ACC) is a lineage-specific carcinoma that occurs nearly exclusively in the pancreas. We report, to our knowledge, the first series of gallbladder carcinoma demonstrating extensive acinar differentiation in the absence of a pancreatic primary. - Source: PubMed
Publication date: 2026/03/29
Yilmaz OsmanAktaş Berk KaanTezcan NurayDeshpande VikramAdsay VolkanVyas Monika - Dysregulation of the CARD11-BCL10-MALT1 (CBM) complex is associated with a group of inborn errors of immunity termed “CBM-opathies,” which encompass a spectrum of clinical manifestations including combined immunodeficiency, autoimmune inflammation, atopic disorders, and lymphoproliferation. In this study, we identified novel compound heterozygous variants in the CBM complex in a patient with a family history of immune dysfunction. The patient inherited the variants CARD11 p.K215N and MALT1 p.K543R/p.M732T from asymptomatic carrier parents. Phenotypically, the patient exhibited a developmental arrest of B lymphocytes at the transitional/naïve B cell stage, accompanied by activation of virus-response pathways. Impaired development of T follicular helper cells was linked to defective germinal center formation and agammaglobulinemia. Furthermore, the patient showed expansion of T peripheral helper cells and a deficiency in regulatory T cells, both associated with autoimmunity and colitis. In vitro studies confirmed an imbalance in Tph/Tfh cell differentiation. Single-cell RNA sequencing further revealed a deficiency in B cell development and an enriched population of pro-inflammatory CD3CD4CD8CD247 T cells, functionally enriched in the MAPK signaling pathway. Mechanistically, the MALT1 K543R and M732T variants attenuated MALT1’s enzymatic activity and compromised its protein stability, while the CARD11 variant disrupted CARD11-mediated promotion of BCL10 filament formation. We demonstrated that these three variants act synergistically to impair NF-κB activation. Specifically, CARD11 cooperates with the co-pathogenic MALT1 and the modifier variant MALT1 to destabilize the functional integrity of the CBM complex, thereby driving the patient’s phenotype. In summary, our study provides new insights into the pathogenesis of autoimmune inflammatory disorders within the spectrum of CBM-opathies and reveals a potential role for the CBM complex in regulating the balance between T peripheral helper and T follicular helper cells. - Source: PubMed
Publication date: 2026/03/26
Li RuiSun XiaochenBao WeiYu HaolanDan YuQingWu ChunmeiMa YanYin HanlinLin WanyiLu LiangjingFu QiongYang Chenghua - Pancreatic acinar cell carcinoma (ACC) is a rare pancreatic malignancy with molecular and clinical features distinct from pancreatic ductal adenocarcinoma (PDAC). We report a 58-year-old man with a 15-cm ACC of the pancreatic body and tail treated by distal pancreatectomy and splenectomy. Complete resection was achieved despite tumor size and surface fissuring suggestive of impending rupture. Operative time was 282 minutes with blood loss of 280 mL. Histopathology showed acinar architecture with B-cell lymphoma 10 (Bcl-10) positivity and nuclear beta-catenin accumulation, consistent with Wnt pathway activation. To clarify the biological differences between ACC and PDAC, we compared their molecular and clinicopathological features. Our analysis demonstrates that ACC's unique molecular profile and growth characteristics enabled successful surgical resection in this giant tumor. This case illustrates how systematic comparison of ACC with PDAC provides insights into the distinct biological behaviors of these pancreatic malignancies. We review current therapeutic advances in PDAC, including targeted therapies and immunotherapy approaches, which may inform future treatment strategies for ACC. - Source: PubMed
Publication date: 2026/02/14
Akiyama RioKawashita YujoOchiai MikuTateishi MasakiUeda TakashiNakamura MasayukiUmeda KoyaHarada SeikoAbe SoseiHaraguchi MasashiYamaguchi JunzoWashida YasuoHachitanda Yoichi - Asthma is a significant allergic condition affecting the respiratory system. Numerous compounds extracted from traditional Chinese herbal medicine show potential benefits for treating airway inflammation associated with bronchial asthma. Astragalus polysaccharide (APS), a class of major extracts from Astragalus membranaceus, exhibit many anti-inflammatory effects. Nonetheless, the underlying mechanisms of APS in asthma remain to be clarified. This study aims to assess the effect and the mechanism by which APS against asthma. The ovalbumin (OVA)-induced asthma mice were employed to assess the roles of APS . Lung tissues were used for H&E, PAS, and Masson staining. Inflammatory cells in bronchoalveolar lavage fluid (BALF) and chemokines in both BALF and serum samples were determined by hemocytometer and ELISA. The expression of the Hedgehog/NLRP3/GSDMD pathway in lung tissues was measured by quantitative real-time PCR and Western blotting. APS displayed lung-protective effects through decreasing airway inflammation and airway remodeling in OVA-induced asthma mice, which was demonstrated by decreasing the number of inflammatory cells and the cytokine levels in BALF and serum, and histopathological changes in lung tissues. Besides, APS treatment could decrease the expression of SHH, SMO, Gli1, Ptch1, NLRP3, GSDMD-N, ASC, Cleaved caspase-1, IL-18, IL-1β, CARMA3, BCL10, and MALT1 in lung tissues. APS improves clinical symptoms of OVA-induced bronchial asthma. The anti-asthmatic effects of APS may be related to the regulatory influences of the Hedgehog/NLRP3/GSDMD pathway. - Source: PubMed
Publication date: 2026/03/16
Yu LiliLiu ZibinZhang RuiLai Jian - Largemouth bass (Micropterus salmoides) is an economically important freshwater fish species in China that is frequently affected by disease outbreaks caused by Aeromonas hydrophila. This study employed an integrated transcriptomic and proteomic approach to investigate the response of the liver in largemouth bass at 72 h post-infection with A. hydrophila via intraperitoneal injection. We identified differentially expressed genes (DEGs; 2136 upregulated and 200 downregulated) and differentially expressed proteins (DEPs; 1683 upregulated and 1817 downregulated). Functional enrichment analysis indicated that the upregulated DEGs/DEPs were significantly involved in immune and inflammatory responses, encompassing pathways, such as TNF signalling, NF-kappa B signalling, complement and coagulation cascades and B cell receptor signalling, while the downregulated DEGs/DEPs were primarily associated with metabolic processes, especially lipid metabolism. Integrated transcriptomic and proteomic analysis identified 420 correlated DEG/DEP pairs, among which 154 were consistently upregulated and 19 consistently downregulated. The upregulation of eight key immune-related DEG/DEPs, including complement components (C1q, C7b, C1r-A), MYD88 and BCL10, was verified by RT-qPCR. Collectively, these findings provide valuable insights into the molecular basis of immune defence against A. hydrophila in largemouth bass and identify potential immune-related biomarkers that may be useful in the development of effective prevention and control strategies. - Source: PubMed
Publication date: 2026/03/13
Chen FuyanWen ShuipingHe XuehaiLei AiyingHuang TingWu YushanTan HonglianLiang YouyongLu XiaohuaSu MeizhenLi JianbinOuyang Xianhua