Ask about this productRelated genes to: CLOCK antibody
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: CLOCK antibody
Related articles to: CLOCK antibody
- Both the geologic and genomic records provide information on the earliest history of terrestrial life. Despite the challenges inherent to the fragmentary and highly metamorphosed earliest rock record, microfossils as old as ∼3.5 billion years (Ga) and potential morphological and isotopic traces in earlier rocks suggest the origin and diversification of life within the planet's first billion years. This is consistent with a growing body of evidence for liquid water in Earth's surface or near-surface environment by around 4.3 Ga, which provides at least one requirement of habitability. Genomic evidence further informs our understanding of early life, including some aspects of its environment, physiology, and metabolism. In addition, ancestral proteome reconstruction and molecular clocks provide clues to the nature and timing of the last universal common ancestor (LUCA), although the latter methodology remains challenging and highly uncertain. Improved molecular clock methods may be able to better constrain the timing of LUCA and the divergence of the major domains of extant life, while further interrogation of the earliest geologic and geochemical records may be able to reveal even earlier evidence for an inhabited planet. - Source: PubMed
Publication date: 2026/05/27
Bell Elizabeth AFournier Gregory P - Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal neuronal electrical activity. Increasing evidence suggests that circadian clock dysfunction contributes to seizure susceptibility and neuronal excitability. Melatonin, a major regulator of circadian rhythm, possesses antioxidant and neuroprotective properties that may influence seizure regulation. Cucurbitacin E (CuE), a triterpenoid compound with potent antioxidant and anti-inflammatory activities, has emerged as a potential therapeutic agent targeting circadian and oxidative pathways. This study investigated the effects of CuE on seizure activity, oxidative balance, melatonin levels, and circadian clock gene expression in a pentylenetetrazol (PTZ)-induced epilepsy model. - Source: PubMed
Publication date: 2026/05/27
Sarıcı Sinem BebekOvayolu ÖzlemYılmaz Şenay Görücü - Obstructive sleep apnea (OSA) is a sleep-disordered breathing condition characterized by recurrent upper-airway obstruction, leading to intermittent hypoxemia, sleep fragmentation, and sympathetic activation. OSA is highly prevalent in patients with cardiovascular diseases and is strongly associated with hypertension, atrial fibrillation, coronary artery disease, heart failure, and adverse prognosis. This review summarizes current evidence on the pathophysiology of OSA, its cardiovascular consequences, and available diagnostic and therapeutic strategies, with particular attention to clinical implications in cardiology practice. We discuss established treatments such as lifestyle interventions, continuous positive airway pressure, mandibular advancement devices, and selected surgical options, as well as emerging therapies, including pharmacological approaches targeting weight loss and ventilatory control. While OSA treatment improves symptoms and quality of life, evidence for cardiovascular event reduction remains heterogeneous and appears strongly influenced by patient selection and treatment adherence. Identifying patients most likely to benefit from targeted OSA management remains a key challenge. - Source: PubMed
Publication date: 2026/05/21
Castiglione VincenzoMorfino PaoloFabiani IacopoGentile FrancescoAirò EdoardoVolpi BenedettaCardinale DanielaPassino ClaudioGiannoni AlbertoEmdin Michele - Obstructive sleep apnea (OSA) is a highly prevalent yet frequently underdiagnosed condition that is associated with significant cardiopulmonary, metabolic, and neurocognitive outcomes. Risk factors for OSA overlap with illnesses commonly observed in intensive care unit (ICU) patients, resulting in a disproportionately elevated burden on healthcare. This structured narrative review synthesizes current evidence regarding the prevalence, diagnostic challenges, and clinical implications of obstructive sleep apnea (OSA) in critically ill adults admitted to intensive care units (ICUs) using PubMed, EMBASE, and Scopus. Key search terms included "obstructive sleep apnea," "ICU," and "critical illness." Results showed that OSA is present in up to 60-70% of ICU patients, yet only ~5% are formally diagnosed during hospitalization. Underdiagnosis is linked to prolonged mechanical ventilation, extubation failure rates as high as 30%, 2-fold higher perioperative complication rates, cardiovascular instability, 1.8-fold greater 30-day ICU readmission rates, and 2.2-fold mortality. Standard screening tools have limited applicability in ICU patients. Emerging alternatives, such as overnight oximetry, polygraphy, and machine learning models lack validation. Our analyses reveal that current diagnostic and treatment strategies are poorly adapted to critically ill patients. Integration of OSA as a part of ICU management, diagnosis, and intervention may reduce readmissions and mortality. - Source: PubMed
Publication date: 2026/05/20
Gharib ChristineKim CatherineLing JunVarma Madhu - Insomnia is common among older adults and is associated with adverse health outcomes, yet evidence on its relationship with healthy lifestyle in Chinese older adults is limited. This study included 4929 participants from the Hubei Memory and Aging Cohort Study (HMACS). A healthy lifestyle score (range 0-6) was constructed based on body weight, drinking alcohol, smoking, regular exercise, diet, and cognitive activity. Participants were categorized into unfavorable (0-2), average (3), and favorable (4-6) lifestyle groups. Insomnia was defined using the Athens Insomnia Scale (AIS ≥ 6), or the Pittsburgh Sleep Quality Index (PSQI > 5). Multivariable logistic regression models were applied to assess the associations of overall and individual healthy behaviors with insomnia risk. Stratified analyses by smoking status and substitution analyses were conducted. Healthier lifestyle was associated with lower risk of insomnia. Compared with the unfavorable group, participants with favorable lifestyle had a 17.5% lower risk of insomnia. Among individual lifestyle behaviors, healthy diet and active cognitive activity were associated with reduced insomnia risk. Stratified analyses showed these associations were only evident among non-current smokers. Substitution analyses suggested that replacing unhealthy behaviors with healthy ones was associated with a lower insomnia risk. Favorable lifestyle, particularly healthy diet and active cognitive activity, is associated with lower insomnia risk among older adults, with stronger associations observed among non-current smokers. - Source: PubMed
Publication date: 2026/05/09
Liu LuZhou WenLuo YuZhang YueyiWang DongxiChen MingWang ZhimingZeng Yan