Ask about this productRelated genes to: ICAM1 antibody
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: ICAM1 antibody
Related articles to: ICAM1 antibody
- SARS-CoV-2 infection is associated with systemic vasculopathy and thromboinflammation. However, the interaction between shear-dependent endothelial function, inflammatory signaling, and thrombosis during viral exposure remains incompletely defined due to limitations of conventional in vitro and animal models. - Source: PubMed
Publication date: 2026/05/08
Suresh SreelakshmyJohn RebeccaCooke John PConnor John HJain Abhishek - This study evaluates the protective potential of Fondaparinux (Fond), a selective antithrombin-mediated Factor Xa inhibitor, in methotrexate-induced hepatotoxicity. The work explores its ability to correct coagulation imbalance, improve endothelial function, and attenuate oxidative and inflammatory cascades (TLR4/NLRP3, NF-κB p65/IL-1β/MCP-1). Animals were allocated into 4 groups. A control group was given distilled water via the intraperitoneal route (i.p.); an MTX group was given a single intraperitoneal injection of MTX (20 mg/kg) on the seventh experimental day; and two groups received prior prophylactic administration of Fondaparinux (at doses of 5 or 10 mg/kg, intraperitoneally) throughout seven consecutive days before as well as for an additional four-day period following MTX administration. MTX significantly elevated hepatic injury markers (AST, ALT, ALP), induced oxidative stress with depleted antioxidants (SOD, GSH), and activated TLR4/NLRP3 signaling, resulting in upregulation of inflammatory mediators (TNF-α, NF-κB p65, IL-18, IL-1β, MCP-1, caspase-1, iNOS, ICAM-1, MPO) and suppression of IL-10 (p < 0.05). Endothelial dysfunction was evidenced by reduced eNOS. MTX also triggered marked coagulation disturbances, including enhanced Factor Xa-dependent thrombin generation, increased tissue factor, fibrin deposition, and elevated PAI-1. Mitochondrial apoptotic signaling was promoted, as indicated by elevated expression of cytochrome c along with induced caspase-3 and caspase-9 activation . Histologically, MTX caused extensive hepatic damage characterized by periportal fibrosis, inflammatory infiltration, bile duct proliferation, hepatocellular necrosis, vacuolation, and vascular congestion. Fondaparinux pretreatment dose-dependently restored hemostatic balance, improved endothelial function, suppressed oxidative and inflammatory responses, attenuated apoptosis, and markedly ameliorated histopathological alterations. Fondaparinux limits methotrexate-associated liver damage through inhibition of Factor Xa-dependent coagulation pathways while providing antioxidant, anti-inflammatory, anti-apoptotic, and hepatoprotective actions. - Source: PubMed
Publication date: 2026/05/09
Saleh AsmaaRaslan Nahed ASelim Heba Mohammed Refat MFarghly Ahmed MohamedShalkami Abdel-Gawad SSallam Mohamed Fathy MohamedElhusseiny Shaza MAljohani Saad Ali SFouda Manar SeleemAli Mohammed Hegazy HassanAllatif Alaa A A AbdMohamed Mohamed Fathy AbdElhamidHanafy Safaa MMohamed Amany FBadawy Amina IbrahimMohamed Somia MokabelElashrey Asmaa MagdyMousa Sara Nagdy MahmoudEl-Dessouki Ahmed M - Fluid protein studies in cerebrospinal fluid (CSF) and plasma have provided important insights into neurodegenerative dementias; however, there is a limited investigation of sex-related differences and cross-biofluid relationships. In Alzheimer's disease (AD), Lewy body dementia (LBD), and frontotemporal dementia (FTD), large-scale, sex-stratified analyses of paired CSF and plasma samples remain scarce. Using the multiplex and ultrasensitive capabilities of NULISAseq™ technology, this study aims to characterize sex- and disease-specific proteomic alterations associated with Central Nervous System (CNS) pathology to explore underlying mechanisms. - Source: PubMed
Publication date: 2026/05/08
Comas-Albertí AinaLladó AlbertEsteller-Gauxax DianaBorrego-Écija SergiFalgàs NeusDakterzada FaridaPérez-Millan AgnèsPuey RogerCollet-Romà TàniaGuillén NúriaMassons MiquelTort-Merino AdriàAugé Josep MariaFernandez-Villullas GuadalupeBosch BeaRuiz-García RaquelNaranjo LauraBalasa MirceaPiñol-Ripoll GerardAntonell AnnaSánchez-Valle Raquel - This study was conducted to delineate layer-specific transcriptomic alterations in the keratoconus (KC) epithelium and stroma and to identify potential biomarkers using machine learning (ML)-based analysis. - Source: PubMed
Publication date: 2026/05/08
Du KaiyuePeng RongmeiXiao GegeQu YiHan LiangHong Jing - Oral inflammatory diseases affect nearly half of all humans, yet mechanisms underlying rapidly-destructive inflammation remain poorly understood. We compared peri-implantitis with moderate- and high-grade periodontitis using integrated microbial and single-cell sequencing (>967,169-cells; single-cell RNA-seq, spatial proteotranscriptomics). Laser capture microdissection with compartmental microbiome analysis revealed reduced bacterial load and diversity in peri-implantitis. Expansion of the Human Periodontal Atlas with peri-implantitis single-cell RNA-seq data (36-samples; 121,395 cells) identified CD34 vascular endothelial cell (VEC) rarefaction and oxidative stress, hypoxia, and NAD⁺ metabolism-associated transcriptional programs enriched in a TNFRSF6B⁺/ICAM1⁺ post-capillary venule (PC-VEC) subpopulation. NAD⁺-consuming ectoenzyme CD38 was selectively enriched and orthogonally confirmed by spatial transcriptomics (6-samples; 283,377-cells) and proteomics (23-samples; 562,397-cells). Spatial neighborhood analyses demonstrated CD38⁺-high PC-VEC expansion, closer proximity, and higher IL16-CD4 T cell signaling in peri-implantitis. Matched high-grade periodontitis biopsies confirmed spatially restricted CD38⁺-VECs despite similar microbial burden, identifying endothelial vasculopathy underlying rapidly advancing oral inflammation and a potential therapeutic axis. - Source: PubMed
Publication date: 2026/05/08
Easter Quinn THuynh Khoa L AStolf Camila SchmidtXie JialiuMatuck Bruno FHasuike AkiraAlvarado-Martinez ZabdielKim William SChen ZhaoxuRibeiro Apoena AguiarPareek NiveditaAzcarate-Peril Andrea MWu DiCasarin RenatoKo Kang ILiu JinzeByrd Kevin M