Ask about this productRelated genes to: eNOS antibody
- Gene:
- NOS3 NIH gene
- Name:
- nitric oxide synthase 3
- Previous symbol:
- -
- Synonyms:
- ECNOS, eNOS
- Chromosome:
- 7q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-23
- Date modifiied:
- 2016-10-05
Related products to: eNOS antibody
Related articles to: eNOS antibody
- Uncoupling protein 2 (UCP2) is expressed in various tissues throughout the body, but its expression in the spleen exceeds that of other organs. However, the precise function of UCP2 for spleen physiology is unclear. The spleen acts as a hub connecting the nervous system and immune system to cardiovascular and metabolic diseases. Here, we analyzed the impact of hypertension on the spleen and the role of UCP2 in this process. Experiments were performed with UCP2-knockout rats and their wild-type littermates. Hypertension was induced by administering the nitric oxide inhibitor L-NAME via tap water. Genetic depletion of UCP2 increased spleen size (splenomegaly) and strongly impaired the expression of genes coding for mitochondrial proteins. Among them, genes coding for proteins involved in oxidative metabolism, such as pyruvate dehydrogenase alpha 1, and the detoxification of reactive oxygen species were down-regulated. Collectively, these alterations in metabolism favor glycolysis and proliferation. Moreover, NOS3 was among the strongest down-regulated genes in UCP2 rats, and the inhibition of nitric oxide synthase by L-NAME mimicked large parts of the expression profile. Neither the depletion of UCP2 nor L-NAME-induced hypertension or combinations thereof affected chronic inflammation. In summary, UCP2 controls fuel consumption in splenic cells in a nitric-oxide-dependent way. - Source: PubMed
Publication date: 2026/07/30
Wagner LeaSchreckenberg RolfItani NadjaSato TsuneshiroSperhake JuliaCesar YvaSchlüter Klaus-Dieter - Vascular aging is driven by a self-sustaining interplay between oxidative stress and chronic low-grade inflammation, collectively referred to as inflammaging. Diosmin, a citrus-derived flavonoid with antioxidant and anti-inflammatory properties, has not previously been investigated in this context. Young (10-week-old) and aged (40-week-old) male Sprague-Dawley rats received diosmin (50 mg/kg/day) or vehicle for 3 months. Vascular function was assessed in mesenteric resistance arteries using pressure myography, while oxidative stress was evaluated by dihydroethidium and mitoSOX staining. Circulating malondialdehyde (MDA), tumor necrosis factor (TNF), lipopolysaccharide-binding protein (LBP) vascular expression of , , and were measured. Aging was associated with impaired endothelium-dependent vasorelaxation, increased vascular DHE and MitoSOX fluorescence and elevated circulating MDA and LBP levels. Chronic diosmin supplementation partially restored endothelial function. The improvement in endothelial function was consistent with a partial preservation of NO-dependent endothelial function, although NO production and bioavailability were not measured directly. Diosmin also significantly reduced vascular DHE and MitoSOX fluorescence in aged animals. These effects were accompanied by decreased plasma MDA and LBP levels, whereas TNF remained unchanged. Diosmin did not significantly affect , or gene's expression, but it attenuated the age-related upregulation of . Overall, diosmin attenuated age-associated vascular oxidative stress and partially improved endothelial function in aged rats. Although the reduction in circulating LBP suggests a possible effect on selected systemic signals associated with endotoxin exposure, additional inflammatory markers and mechanistic studies will be required to determine whether diosmin modulates vascular inflammaging. - Source: PubMed
Publication date: 2026/08/07
Valdiserra GiuliaDi Salvo CleliaFornai MatteoPellegrini CarolinaCampigli LetiziaMengozzi AlessandroCappelli FedericaDuranti EmilianoIppolito ChiaraColucci RocchinaBernardini NunziaVirdis AgostinoAntonioli Luca - Primary open-angle glaucoma (POAG) is a complex multifactorial optic neuropathy involving genetic, vascular, oxidative, inflammatory, and neurodegenerative mechanisms. Despite advances in genome-wide studies, the contribution of genetic variants remains incompletely characterized in underrepresented Latin American populations. This study aimed to characterize the genetic landscape of POAG in a Colombian cohort by identifying previously reported glaucoma-associated variants, rare candidate variants, and pharmacogenomic markers and integrating these findings into biologically relevant pathways. - Source: PubMed
Publication date: 2026/08/04
Casanova CarlosValencia-Peña ClaudiaSaldarriaga-Gil WilmarLozano-Cruz EdgarCastillo Andrés - Perfluoroalkyl and polyfluoroalkyl substances (PFAS), man-made fluorinated chemicals, are widely distributed in the environment and can enter human habitats through various pathways. However, the mechanisms by which PFAS affect metabolic health are not fully understood. - Source: PubMed
Publication date: 2026/08/25
Qiao ZipengLiu TaoHu XiongfeiNi WeiweiJiang BohanLu Chan - To propose and make testable a mechanistic hypothesis for post-exertional malaise (PEM) in a clinically distinct subset of Long COVID patients, in whom delayed exertional symptoms coexist with consistently normal macrovascular investigations. - Source: PubMed
Karipidis Yiannis KKaripidis Konstantinos Y