Ask about this productRelated genes to: PGA5 antibody
- Gene:
- PGA5 NIH gene
- Name:
- pepsinogen 5, group I (pepsinogen A)
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: PGA5 antibody
Related articles to: PGA5 antibody
- The 90-kDa heat shock protein (HSP90) is a central component of the chaperone system for protein homeostasis (proteostasis). In Arabidopsis, AtHSP90.5 is the sole chloroplast-localized HSP90 family member, yet its role in chloroplast proteostasis remains poorly characterized. Here, we identify and characterize the pale green arabidopsis 5 mutant, pga5-1, which exhibits defective chloroplast development and impaired accumulation of photosynthetic protein complexes. Genetic analysis revealed that pga5-1 is a hypomorphic allele of AtHSP90.5, harboring a missense mutation (G646E) localized closely to the substrate-binding site. Biochemical studies demonstrated that AtHSP90.5 interacts with AtFtsH12, and the ATPase activity of AtHSP90.5 is essential for the oligomerization of AtFtsH12 complexes. Strikingly, the mutation of the conserved residue (E106A) for the ATPase activity of AtHSP90.5 can rescue the embryonic lethality of AtHSP90.5 null mutants, yielding albino seedlings with non-photosynthetic plastids, and partially complement pga5-1. Furthermore, we show that AtHSP90.5 associates with subunits of light-harvesting antenna complexes, including LhcB1, LhcB2, and LhcA1, and is epistatic to PGA4/cpSRP54 in regulating the accumulation of a chimeric chloroplast marker protein, LhcB2-GFP. Collectively, our findings establish a critical role for AtHSP90.5 in maintaining photosynthesis protein complexes and uncover a previously unknown functional link between AtHSP90.5 and AtFtsH12 in chloroplast protein translocation. - Source: PubMed
Wang XiaominZhong JiahuiLi BilangYang ShuoWang PeiyiShao JingxiaMeng JingjingLiu XiayanYu FeiQi Yafei - Productive lifespan is a critical economic trait for both dual-purpose and dairy cows, as it determines lifetime milk production. Xinjiang Brown cattle, a dual-purpose breed widely raised in China's Xinjiang region, have a population of nearly two million and play a vital role in the local economy. However, the molecular mechanisms influencing aging and productive lifespan in Xinjiang Brown cattle remain largely unknown. In this study, we collected white blood cell (leukocyte) transcriptome data from 66 Xinjiang Brown cattle, aged 31 to 160 months, to investigate the dynamic changes in their gene expression profiles across different ages and identify genes potentially influencing their aging process. - Source: PubMed
Publication date: 2025/05/29
Wang JiahaoZhang MenghuaZhao QingyaoChen SiqianTang YongjieChen QuanzhenXu LeiWang DanGuo XiaopingXing KaiWang YachunChuduanWang Huang XixiaYu Ying - The emergence of single-cell technology offers a unique opportunity to explore cellular similarity and heterogeneity between precancerous diseases and solid tumors. However, there is lacking a systematic study for identifying and characterizing similarities at single-cell resolution. - Source: PubMed
Publication date: 2024/02/14
Tong MengshaLuo ShijieGu LinWang XinkangZhang ZheyangLiang ChenyuHuang HuaqiangLin YuxiangHuang Jialiang - The fungal cell wall consists of glucans, mannoproteins, and chitin and is essential for cell viability, morphogenesis, and pathogenesis. The enzymes of the GH72 family are responsible for ß-(1,3)-glucan elongation and branching, which is crucial for the formation of the glucan-chitin polymer at the bud neck of yeast cells. In the human fungal pathogen Candida albicans, there are five GH72 enzyme-encoding genes: , and . It is known that expression of and is controlled by the pH-responsive Rim101 pathway through the transcription factor Rim101. In this study, we have demonstrated that the transcription expression of is also controlled by the transcription factor Crz1 through its binding motif in the promoter. Therefore, we have uncovered a dual-control mechanism by which expression is negatively regulated via CaRim101 through the pH-responsive pathway and positively modulated by CaCrz1 through the calcium/calcineurin signaling pathway. - Source: PubMed
Publication date: 2023/12/06
Jiang LinghuoXu HuihuiWei MinGu YiyingYan HongboPan LingxinWei Chunyu - Despite playing a key role in digestion, there is only a broad characterization of the spatiotemporal development of the three glandular regions of the stomach (cardiac, fundic and pyloric) in the weaned pig. Hence, the objective of this experiment was to explore the differential expression (DE) of a panel of key genes within the three glandular regions of the stomach. Eight pigs were sacrificed at d 8 post-weaning, and three mucosal samples were collected from each stomach's glandular regions. The expression of a panel of genes were measured using QPCR. The true cardiac gland region was characterized by increased expression of , , and relative to the two other regions ( < 0.05). The fundic gland region was characterized by increased expression of , C, , , , , , , , and compared to the two other regions ( < 0.05). The pyloric gland region was characterized by exclusive expression of ( < 0.05). A transition region between the cardiac and fundic region (cardiac-to-oxyntic transition) was observed with a gene expression signature that resembles a cross of the signatures found in the two regions. In conclusion, unique gene expression signatures were identifiable in each of the glandular regions, with a cardiac-to-oxyntic transition region clearly identifiable in the post-weaned pigs' stomachs. - Source: PubMed
Publication date: 2023/07/20
Kiernan Dillon PO'Doherty John VConnolly Kathryn RuthRyan MarionSweeney Torres