Ask about this productRelated genes to: MDM4 antibody
- Gene:
- MDM4 NIH gene
- Name:
- MDM4 regulator of p53
- Previous symbol:
- -
- Synonyms:
- MDMX, HDMX
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-05
- Date modifiied:
- 2019-01-25
Related products to: MDM4 antibody
Related articles to: MDM4 antibody
- Cisplatin is a widely used chemotherapeutic drug for various types of malignant tumors, but its nephrotoxic side effects limit its clinical application. There have been numerous reports and studies on cisplatin-induced acute kidney injury (AKI). Through transcriptomic and single-cell analyses, we found that USP35 is highly expressed in AKI and is closely related to MDM4. We investigated the role and mechanism of USP35-mediated MDM4 ubiquitination in AKI using renal epithelial cells and animal models. In a kidney-specific USP35 knockout model, AKI was significantly improved, and endothelial ferroptosis was inhibited. Overexpression of USP35 can promote AKI and endothelial ferroptosis. USP35 induces the autophagic degradation of MDM4 following deubiquitination, which activates the P53 signaling pathway mediating endothelial ferroptosis. We propose that the USP35-MDM4-P53 signaling pathway plays an important role in AKI and indicates that USP35 is a potential therapeutic target for AKI. - Source: PubMed
Publication date: 2026/05/25
Han ChenyangGuo LiLi WenyanWu ShashaSheng JianLv YahuiYang YiLi MingTang Zhiling - High-altitude hypoxia (HAH) can cause adverse reactions, such as tinnitus and barotrauma, but the role of mitotic catastrophe (MC) in HAH remains unreported. This study investigated MC-associated biomarkers in HAH. - Source: PubMed
Publication date: 2026/05/21
Zhao WenwenLiu DefangLuo TingWu Yang - Chemotherapeutic resistance remains a major cause of treatment failure in bladder cancer. While the epithelial-mesenchymal transition (EMT) is a known driver of metastasis and drug resistance, its regulatory mechanisms require further elucidation. This study investigates the role of murine double minute 4 (MDM4), a key p53 suppressor, in mediating cisplatin resistance through the EMT program. - Source: PubMed
Publication date: 2026/03/26
Cai SaiminRen XueningXia DaoqingWang MengChen XinZhu YanWang Yan - Hematopoietic stem and progenitor cells support a lifetime supply of blood and immune cells and constitute a powerful cell therapy platform for hematologic diseases. In this study, we define oxygen-dependent activities of hematopoietic stem and progenitor cells. We found that lineage-defined progenitor cells from umbilical cord blood, bone marrow, and mobilized peripheral blood showed increased expansion in high oxygen, while primitive cells- including those from cord blood with in vivo potency- were maintained at higher frequencies in low physiologic O. Single cell transcriptomic profiling of hematopoiesis under varying oxygen revealed the expected modulation of molecular hypoxia programs, including HIF and MTORc signaling. Transcriptomics also identified genes that are understudied in the context of oxygen dependency including MDM4 pathway and PRSS2, which we found is an mRNA biomarker for hematopoietic cell potency. Transcriptional changes together with biochemical validation revealed that low oxygen preserves cells with lower metabolic activity in a less proliferative state that exhibit decreased accumulation of stress markers. This likely occurs via dynamic interplay of multiple molecular programs and may drive differences in cell potency. Collectively, these data identify oxygen-sensing pathways as targets to improve cell therapies and suggest that local oxygenation dictates hematopoietic potential in anatomic niches. - Source: PubMed
Publication date: 2026/05/15
Ropa JamesGutch SarahWathen LindsayKim So JeongPark JiminNewton JessicaWhitacre GracieAljoufi ArafatCooper ScottVan't Hof WouterKaplan Mark HCapitano Maegan L - Compared to European American women, African American women are more likely to be diagnosed with triple-negative breast cancer (TNBC). This difference may be partially due to genetic factors. This study aims to investigate associations of African ancestry and risk variants with TNBC among African American women. - Source: PubMed
Publication date: 2026/05/07
Jia GuochongLiu LiliPing JieFiorica Peter NGuo XingyiTao RanLi BingshanGu JianJohn Esther MOlopade Olufunmilayo IPress Michael FBrewster Abenaa MOlshan Andrew FZirpoli GaryButler Ebonee NHuang MaoshengHuo DezhengPalmer Julie RHaiman Christopher AAmbrosone Christine BTroester Melissa ALong JirongYao SongZheng Wei