Ask about this productRelated genes to: MLH1 antibody
- Gene:
- MLH1 NIH gene
- Name:
- mutL homolog 1
- Previous symbol:
- COCA2
- Synonyms:
- HNPCC, FCC2, HNPCC2
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2019-04-23
Related products to: MLH1 antibody
Related articles to: MLH1 antibody
- DNA mismatch repair (MMR) deficiency is a clinically important biomarker in human oncology, yet its relevance in feline neoplasia remains poorly understood due to limited characterisation and the absence of validated reagents. In this study, we established a practical immunohistochemistry (IHC) approach for evaluating feline MMR proteins by confirming the cross-reactivity of anti-human MLH1, MSH2 and MSH6 antibodies using CRISPR/Cas9-engineered feline tumour cell lines lacking each target gene. Using these validated antibodies, we conducted a pilot screening to assess MMR protein expression in 83 feline tumours and observed variable reductions or losses of MLH1, MSH2 and MSH6 across several tumour types. Notably, MLH1 expression was lost in all melanoma cases (6/6, 100%) and in most osteosarcomas (14/15, 93%), indicating that MMR perturbations may be particularly relevant in these malignancies. These findings provide the first analytically validated framework for assessing MMR proteins in feline oncology and suggest that MMR dysregulation may be more widespread than previously recognised. Although the clinical sample size is limited, this initial pilot screening maps the preliminary landscape of feline MMR protein expression. Further large-scale validation studies incorporating microsatellite instability testing, methylation analysis and genomic profiling are warranted to clarify the biological significance of these alterations. - Source: PubMed
Publication date: 2026/08/16
Nishibori ShomaSakurai MasashiKagawa YumikoNishigaki KazuoNakagawa TakayukiInanaga SakuyaIgase MasayaMizuno Takuya - A woman in her early 40s with MLH1-deficient Lynch syndrome was incidentally found to have a cecal gut-associated lymphoid tissue (GALT)/dome carcinoma during routine surveillance colonoscopy. This case highlights the co-occurrence of 2 rare entities: a germline pathogenic variant and a GALT/dome carcinoma, now recognized within the lymphoglandular complex-like carcinoma spectrum, which carries potential for nodal metastasis. The intersection of mismatch repair deficiency and GALT/dome carcinoma raises a management dilemma: prophylactic colectomy vs endoscopic surveillance in the absence of high-risk histologic features. We review the literature to guide management in this rare scenario. - Source: PubMed
Publication date: 2026/08/14
Deshpande VishalSharma AshishTiwari AngadMupparaju Jaya SaiBodla TejDahiya Dushyant Singh - Pathogenic mutations in the mismatch repair (MMR) genes cause Lynch syndrome. Adenoma resection can prevent colorectal cancer (CRC), but the occurrence of precancerous lesions is understudied in Lynch syndrome. - Source: PubMed
Publication date: 2026/07/08
Atarere JosephBilalaga Maria MalakVasireddy RamyaMensah BonifaceGaddipati Greeshma NSingh SimardeepAkhiwu Ted OWoo StephanieDash ChiranjeevKanth Priyanka - Uterine Corpus Endometrial Carcinoma (UCEC) is the most common gynecologic malignancy, with molecular heterogeneity influencing prognosis and treatment response. Although TCGA-defined molecular subtypes and multi-omics datasets have improved biological understanding of UCEC, externally evaluated computational frameworks for molecular stratification remain limited. To address this, we developed EMMA-STRAT, a supervised multi-omics machine learning framework integrating mRNA expression, miRNA expression, and DNA methylation data to classify UCEC genomic subtypes and microsatellite instability (MSI) status. - Source: PubMed
Publication date: 2026/07/23
Patel NaisargSalumets AndresModhukur Vijayachitra - To analyze the type and frequency druggable mutations in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). - Source: PubMed
Publication date: 2026/08/13
Steenbock OliviaRieger ConstantinHeidenreich JulianPaffenholz PiaPfister DavidBrandenstein Melanie vonHeidenreich Axel