Ask about this productRelated genes to: EPHA1 antibody
- Gene:
- EPHA1 NIH gene
- Name:
- EPH receptor A1
- Previous symbol:
- EPHT, EPHT1
- Synonyms:
- EPH
- Chromosome:
- 7q34-q35
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-16
- Date modifiied:
- 2018-02-13
Related products to: EPHA1 antibody
Related articles to: EPHA1 antibody
- Alzheimer's disease (AD) and related dementias are a growing health and economic burden in India. Blood levels of amyloid beta (Ab), tau, and other proteins marking neuronal injury are biomarkers of AD risk and are potentially important for AD prevention. - Source: PubMed
Publication date: 2026/08/19
Abu-Amara HasanZhao WeiLi ZhengLeung Yuk YeeSchellenberg Gerard DWang Li-SanCrimmins Eileen MThyagarajan BharatAnwar MasroorHu PerryDey SharmisthaDey Aparajit BZhou XiangThangaraj KumarasamyLee JinkookKardia Sharon L RSmith Jennifer A - Nucleoside analogues are traditionally developed as antimetabolites that interfere with nucleic acid synthesis after intracellular phosphorylation. In this study, inspired by the 3',4'-unsaturated sugar scaffold of ddhCTP, we designed and synthesized a series of 3',4'-unsaturated nucleoside analogues to explore their antiproliferative potential and possible non-classical cellular effects. Among the synthesized compounds, 17k, a C-nucleoside bearing both a 3',4'-unsaturated sugar moiety and a chlorinated remdesivir-like base, exhibited potent antiproliferative activity against HepG2 cells, with an IC₅₀ value of 2.27 ± 0.36 μM, lower than that of gemcitabine under the same assay conditions. In the nonmalignant GES-1 epithelial cell line, 17k showed an IC₅₀ value of 34.26 ± 3.45 μM, corresponding to a selectivity index of 15.1 relative to HepG2 cells. Closely related compounds 12 and 17j showed no detectable activity, indicating a narrow structure-activity relationship. Exploratory single-concentration kinase profiling at 20 μM showed strong inhibition of several transcription-associated CDK/cyclin complexes (CDK13/CycK, CDK12/CycK, CDK9/CycT1, CDK19/CycC, and CDK8/CycC) and selected receptor tyrosine kinases (KDR/VEGFR2, RET, EPHA1, and FLT3). Compound 17k also suppressed colony formation and wound closure, induced apoptosis, and caused S-phase accumulation in HepG2 cells. These findings identify 17k as a nucleoside analogue with unanticipated antiproliferative activity and suggest that kinase modulation may contribute to its cellular effects. - Source: PubMed
Publication date: 2026/08/14
Wang SongYang JingYang XinyueHuang HaoZou HaiyangZhang YuZhang XushanLuo CongcongZhao BingLiu Feng-WuHerdewijn Piet - APOE ε4 is the strongest common genetic risk factor for Alzheimer's disease (AD), yet many carriers remain cognitively unimpaired into late life. We tested whether protected ε4-first plasma proteomics could identify proteins associated with delayed clinical onset. - Source: PubMed
Le Guen YannPark JunyoungPeña-Tauber AndrésGreicius Michael D - -ε4 is the strongest common genetic risk factor for Alzheimer's disease (AD), yet many carriers remain cognitively unimpaired into late life. We tested whether a protected-ε4-first proteomic approach could identify plasma proteins associated with delayed clinical onset among ε4 carriers. - Source: PubMed
Publication date: 2026/05/01
Guen Yann LePark JunyoungPeña-Tauber AndrésGreicius Michael D - Ephrin type-A receptor 1 (EPHA1) has been identified as a potential contributor to the pathogenesis of Parkinson's disease (PD). The complex interactions between PD symptoms and the EPHA1 protein warrant further exploration. - Source: PubMed
Lin Yu-ChenTan Chun-HsiangHong Wei-PinYu Rwei-Ling