Ask about this productRelated genes to: NT5E antibody
- Gene:
- NT5E NIH gene
- Name:
- 5'-nucleotidase ecto
- Previous symbol:
- NT5
- Synonyms:
- CD73, eN, eNT, CALJA
- Chromosome:
- 6q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-02-23
- Date modifiied:
- 2016-10-05
Related products to: NT5E antibody
Related articles to: NT5E antibody
- Excessive activation of the adenosine A receptor (AR) contributes to chronic neuroinflammation, in part through spatial coupling with the adenosine-generating enzyme CD73, which enables localized adenosine signaling. Coordinated regulation of and across neuropathological conditions supports dual targeting of the CD73/AR axis to constrain maladaptive inflammatory signaling. - Source: PubMed
Publication date: 2026/04/22
Mihajlovic KatarinaDragic MiloradAdzic Bukvic MarijaMartic TeodoraStevanovic IvanaVinit StéphaneBleuzé MarêvaMansart ArnaudAdam LucilleNedeljkovic Nadezda - Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited therapeutic options. Immune checkpoint inhibitors (ICIs) modestly improve outcomes, but predictive biomarkers are lacking. CD73, an ecto-5'-nucleotidase, generates immunosuppressive adenosine and may attenuate ICI efficacy. - Source: PubMed
Publication date: 2026/04/25
Saiki MasafumiInoue TomohiroTakusagawa KazuhoHomma KentaFuruya SatoshiShimamura SoOmori ChisaIde ShuichiroHoshino YukiUchida YoshinoriYamaguchi YoheiIkemura ShinnosukeKondo TetsuoSoejima Kenzo - Changes within neurotransmitter systems are associated with variation in anxiety-related behavior. The adenosine signaling pathway has been linked to anxiety, and caffeine has been utilized as a modulator. However, studies have not considered the impact of an individual's stress coping style (e.g., proactive, reactive) and the corresponding differences in neuromolecular signaling that can influence behavioral responses. - Source: PubMed
Klucas Sydney EWong Ryan Y - Urothelial bladder cancer (BCa) is marked by high recurrence and mortality, and the efficacy of PD-1/PD-L1 immunotherapy remains limited because of immune evasion. The adenosinergic pathway (AP), mediated by ectonucleotidases CD39 and CD73, is a key immunosuppressive mechanism, but its role in BCa remains unclear. We conducted an integrated immunophenotypic analysis of peripheral blood (PB) and the tumor microenvironment (TME) from 39 patients with BCa and 14 healthy controls using multicolor flow cytometry and immunohistochemistry. High-risk (HR) patients exhibited systemic immunosuppression, characterized by an elevated neutrophil-to-lymphocyte ratio and increased circulating regulatory T cells (Tregs), along with reduced cytotoxic γδ T cells and diminished Th1/Tc1 functional subtypes. In the TME, we observed reduced CD8 T cell infiltration accompanied by increased Tregs, and phenotypes characterized by poor immune infiltration in the tumor core predominated across the cohort. In both PB and the TME, CD39 and CD73 expression on T cells strongly correlated with an immunosuppressive environment, marked by increased M2-like macrophages and decreased effector T cells. Circulating double-positive T cells (CD4CD39CD73 and CD8CD39CD73) mirrored the intratumoral T-cell composition, suggesting their potential as non-invasive biomarkers. Elevated frequencies of circulating single-positive CD8CD39 and CD8CD73 T-cells were significantly associated with higher pathological grade and distinguished high-grade tumors with moderate accuracy (AUC > 0.70). This study demonstrates that BCa is characterized by extensive AP-linked immunosuppression, and that specific ectonucleotidase-expressing circulating T-cell subsets may serve as non-invasive biomarkers for assessing tumor infiltration and grade. - Source: PubMed
Publication date: 2026/04/22
Furriel FredericoLaranjeira PaulaPereira MargaridaSilva SandraSilva IsabelFontinha GuilhermeSousa VítorGomes CéliaParada BelmiroPaiva Artur - Pulmonary hypertension (PH) is a severe progressive disease characterised by elevated pulmonary vascular resistance and right ventricular hypertrophy. Increasing evidence has highlighted the vital role of nicotinamide adenine dinucleotide (NAD) metabolism in cardiovascular disease. However, the role of NAD metabolism-related genes (NMRGs) in PH remains unclear. In this study, we aimed to identify novel NMRGs as biomarkers in PH. - Source: PubMed
Publication date: 2026/04/07
Chu YananYang JinxiuYe TianxinYu FangcongWang QianZhuo Jingming